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作者：Wang, Zhe; Halati, Catalin-Mihai; Bernier, Jean-Sebastien; Ponomaryov, Alexey; Gorbunov, Denis I.; Niesen, Sandra; Breunig, Oliver; Klopf, J. Michael; Zvyagin, Sergei; Lorenz, Thomas; Loidl, Alois; Kollath, Corinna
作者单位：Dortmund University of Technology; University of Cologne; University of Augsburg; University of Geneva; University of Bonn; University of Northern British Columbia; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
摘要：Stable composite objects, such as hadrons, nuclei, atoms, molecules and superconducting pairs, formed by attractive forces are ubiquitous in nature. By contrast, composite objects stabilized by means of repulsive forces were long thought to be theoretical constructions owing to their fragility in naturally occurring systems. Surprisingly, the formation of bound atom pairs by strong repulsive interactions has been demonstrated experimentally in optical lattices1. Despite this success, repulsive...
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作者：[Anonymous]
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作者：Lai, Ke; Pritisanac, Iva; Liu, Zhen-Qi; Liu, Han-Wei; Gong, Li-Na; Li, Ming-Xian; Lu, Jian-Fei; Qi, Xin; Xu, Tian-Le; Forman-Kay, Julie; Shi, Hai-Bo; Wang, Lu-Yang; Yin, Shan-Kai
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Shanghai Center for Brain Science & Brain-Inspired Technology; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Medical University of Graz; Shanghai Jiao Tong University; University of Toronto
摘要：Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-d-aspartate receptor)-dependent cell death pathways in stroke(1,2), but unsuccessful clinical trials with NMDAR antagonists implicate the engagement of other mechanisms(3-7). Here we show that glutamate and its structural analogues, including NMDAR antagonist l-AP5 (also known as APV), robustly potentiate currents mediated by acid-sensing ion channels (ASICs) associated with acidosis-induced neurotoxicity in s...
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作者：Abrego, Nerea; Furneaux, Brendan; Hardwick, Bess; Somervuo, Panu; Palorinne, Isabella; Aguilar-Trigueros, Carlos A.; Andrew, Nigel R.; Babiy, Ulyana V.; Bao, Tan; Bazzano, Gisela; Bondarchuk, Svetlana N.; Bonebrake, Timothy C.; Brennan, Georgina L.; Bret-Harte, Syndonia; Bassler, Claus; Cagnolo, Luciano; Cameron, Erin K.; Chapurlat, Elodie; Creer, Simon; D'Acqui, Luigi P.; de Vere, Natasha; Desprez-Loustau, Marie-Laure; Dongmo, Michel A. K.; Jacobsen, Ida B. Dyrholm; Fisher, Brian L.; de Jesus, Miguel Flores; Gilbert, Gregory S.; Griffith, Gareth W.; Gritsuk, Anna A.; Gross, Andrin; Grudd, Hakan; Halme, Panu; Hanna, Rachid; Hansen, Jannik; Hansen, Lars Holst; Hegbe, Apollon D. M. T.; Hill, Sarah; Hogg, Ian D.; Hultman, Jenni; Hyde, Kevin D.; Hynson, Nicole A.; Ivanova, Natalia; Karisto, Petteri; Kerdraon, Deirdre; Knorre, Anastasia; Krisai-Greilhuber, Irmgard; Kurhinen, Juri; Kuzmina, Masha; Lecomte, Nicolas; Lecomte, Erin; Loaiza, Viviana; Lundin, Erik; Meire, Alexander; Mesic, Armin; Miettinen, Otto; Monkhouse, Norman; Mortimer, Peter; Mueller, Joerg; Nilsson, R. Henrik; Nonti, Puani Yannick C.; Norden, Jenni; Norden, Bjoern; Norros, Veera; Paz, Claudia; Pellikka, Petri; Pereira, Danilo; Petch, Geoff; Pitkaenen, Juha-Matti; Popa, Flavius; Potter, Caitlin; Purhonen, Jenna; Paetsi, Sanna; Rafiq, Abdullah; Raharinjanahary, Dimby; Rakos, Niklas; Rathnayaka, Achala R.; Raundrup, Katrine; Rebriev, Yury A.; Rikkinen, Jouko; Rogers, Hanna M. K.; Rogovsky, Andrey; Rozhkov, Yuri; Runnel, Kadri; Saarto, Annika; Savchenko, Anton; Schlegel, Markus; Schmidt, Niels Martin; Seibold, Sebastian; Skjoth, Carsten; Stengel, Elisa; Sutyrina, Svetlana V.; Syvaenperae, Ilkka; Tedersoo, Leho; Timm, Jebidiah; Tipton, Laura; Toju, Hirokazu; Uscka-Perzanowska, Maria; Van der Bank, Michelle; Van der Bank, F. Herman; Vandenbrink, Bryan; Ventura, Stefano; Vignisson, Solvi R.; Wang, Xiaoyang; Weisser, Wolfgang W.; Wijesinghe, Subodini N.; Wright, S. Joseph; Yang, Chunyan; Yorou, Nourou S.; Young, Amanda; Yu, Douglas W.; Zakharov, Evgeny V.; Hebert, Paul D. N.; Roslin, Tomas; Ovaskainen, Otso
作者单位：University of Jyvaskyla; University of Helsinki; University of Helsinki; University of New England; Southern Cross University; MacEwan University; National University of Cordoba; University of Hong Kong; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); CSIC - Instituto de Ciencias del Mar (ICM); University of Alaska System; University of Alaska Fairbanks; Goethe University Frankfurt; University of Bayreuth; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Saint Marys University - Canada; Swedish University of Agricultural Sciences; Bangor University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca sugli Ecosistemi Terrestri (IRET); National Biodiversity Future Center; University of Copenhagen; INRAE; Universite de Bordeaux; Greenland Institute of Natural Resources; California Academy of Sciences; Aberystwyth University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; University of California System; University of California Los Angeles; Aarhus University; University of Parakou; University of Guelph; University of Waikato; Finland National Institute for Health & Welfare; University of Helsinki; Natural Resources Institute Finland (Luke); Mae Fah Luang University; University of Hawaii System; University of Hawaii Manoa; University of Guelph; Swiss Federal Institutes of Technology Domain; ETH Zurich; Natural Resources Institute Finland (Luke); Siberian Federal University; University of Vienna; University of Moncton; University of Moncton; University of Zurich; Rudjer Boskovic Institute; University of Helsinki; Chinese Academy of Sciences; Kunming Institute of Botany, CAS; University of Wurzburg; University of Gothenburg; Norwegian Institute Nature Research; Universidade Estadual Paulista; Universidade de Sao Paulo; University of Helsinki; Wuhan University; University of Nairobi; Wageningen University & Research; University of Worcester; University of Jyvaskyla; University of Turku; Mae Fah Luang University; Russian Academy of Sciences; Southern Scientific Center, Russian Academy of Sciences; University of Tartu; University of Tartu; Tartu University Institute of Ecology & Earth Sciences; Aarhus University; Technical University of Munich; Aarhus University; University of Wurzburg; University of Turku; King Saud University; Chaminade University Honolulu; Kyoto University; Kyoto University; University of Johannesburg; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Smithsonian Institution; Smithsonian Tropical Research Institute; University of East Anglia; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Norwegian University of Science & Technology (NTNU)
摘要：Fungi are among the most diverse and ecologically important kingdoms in life. However, the distributional ranges of fungi remain largely unknown as do the ecological mechanisms that shape their distributions(1,2). To provide an integrated view of the spatial and seasonal dynamics of fungi, we implemented a globally distributed standardized aerial sampling of fungal spores(3). The vast majority of operational taxonomic units were detected within only one climatic zone, and the spatiotemporal pa...
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作者：Birner, Suzanne K.; Cottrell, Elizabeth; Davis, Fred A.; Warren, Jessica M.
作者单位：Smithsonian Institution; Smithsonian National Museum of Natural History; University of Minnesota System; University of Minnesota Duluth; University of Delaware
摘要：The oxygen fugacity (fO2) of convecting upper mantle recorded by ridge peridotites varies by more than four orders of magnitude1-3. Although much attention has been given to mechanisms that drive variations in mantle fO2 between tectonic settings1,3,4 and to comparisons of fO2 between modern rocks and ancient-mantle-derived rocks5-10, comparatively little has been done to understand the origins of the high variability in fO2 recorded by peridotites from modern mid-ocean ridge settings. Here we...
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作者：Gewin, Virginia; Shirani, Shiva
作者单位：Universidad de Malaga
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作者：Kozlov, Max
摘要：Researchers have tried a bunch of strategies to get more negative results into the literature. Nature asks whether they are working.
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作者：Sykes, Rebecca Wragg
作者单位：University of Cambridge; University of Liverpool
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作者：[Anonymous]
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作者：Bosch, Miriam; Kallin, Nina; Donakonda, Sainitin; Zhang, Jitao David; Wintersteller, Hannah; Hegenbarth, Silke; Heim, Kathrin; Ramirez, Carlos; Fuerst, Anna; Lattouf, Elias Isaac; Feuerherd, Martin; Chattopadhyay, Sutirtha; Kumpesa, Nadine; Griesser, Vera; Hoflack, Jean-Christophe; Siebourg-Polster, Juliane; Mogler, Carolin; Swadling, Leo; Pallett, Laura J.; Meiser, Philippa; Manske, Katrin; de Almeida, Gustavo P.; Kosinska, Anna D.; Sandu, Ioana; Schneider, Annika; Steinbacher, Vincent; Teng, Yan; Schnabel, Julia; Theis, Fabian; Gehring, Adam J.; Boonstra, Andre; Janssen, Harry L. A.; Vandenbosch, Michiel; Cuypers, Eva; Oellinger, Rupert; Engleitner, Thomas; Rad, Roland; Steiger, Katja; Oxenius, Annette; Lo, Wan-Lin; Klepsch, Victoria; Baier, Gottfried; Holzmann, Bernhard; Maini, Mala K.; Heeren, Ron; Murray, Peter J.; Thimme, Robert; Herrmann, Carl; Protzer, Ulrike; Boettcher, Jan P.; Zehn, Dietmar; Wohlleber, Dirk; Lauer, Georg M.; Hofmann, Maike; Luangsay, Souphalone; Knolle, Percy A.
作者单位：Technical University of Munich; Roche Holding; University of Freiburg; Ruprecht Karls University Heidelberg; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Technical University of Munich; University of London; University College London; Technical University of Munich; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; German Center for Infection Research; Swiss Federal Institutes of Technology Domain; ETH Zurich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; University of Toronto; University Health Network Toronto; Toronto General Hospital; University of Toronto; Erasmus University Rotterdam; Erasmus MC; University of Toronto; University Health Network Toronto; Toronto General Hospital; Maastricht University; Technical University of Munich; Technical University of Munich; Utah System of Higher Education; University of Utah; Medical University of Innsbruck; Technical University of Munich; Max Planck Society; Technical University of Munich
摘要：Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide(1,2), in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes(3-7). Here we demonstrate that a liver immune rheostat renders virus-specific CD8 T cells refractory to activation and leads to their loss of effector functions. In preclinical models of persistent infection with hepatotropic viruses such as HBV, dysfunctional virus-specific CX...
