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作者：[Anonymous]
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作者：Laporte, Manon; Jochmans, Dirk; Bardiot, Dorothee; Desmarets, Lowiese; Debski-Antoniak, Oliver J.; Mizzon, Giulia; Abdelnabi, Rana; Leyssen, Pieter; Chiu, Winston; Zhang, Zhikuan; Nomura, Norimichi; Boland, Sandro; Ohto, Umeharu; Stahl, Yannick; Wuyts, Jurgen; De Jonghe, Steven; Stevaert, Annelies; van Hemert, Martijn J.; Bontes, Brenda W.; Wanningen, Patrick; Groenewold, G. J. Mirjam; Zegar, Aneta; Owczarek, Katarzyna; Joshi, Sanjata; Koukni, Mohamed; Arzel, Philippe; Klaassen, Hugo; Vanherck, Jean-Christophe; Vandecaetsbeek, Ilse; Cremers, Niels; Donckers, Kim; Francken, Thibault; Van Buyten, Tina; Rymenants, Jasper; Schepers, Joost; Pyrc, Krzysztof; Hilgenfeld, Rolf; Dubuisson, Jean; Bosch, Berend-Jan; Van Kuppeveld, Frank; Eydoux, Cecilia; Decroly, Etienne; Canard, Bruno; Naesens, Lieve; Weynand, Birgit; Snijder, Eric J.; Belouzard, Sandrine; Shimizu, Toshiyuki; Bartenschlager, Ralf; Hurdiss, Daniel L.; Marchand, Arnaud; Chaltin, Patrick; Neyts, Johan
作者单位：KU Leuven; Universite de Lille; Pasteur Network; Institut Pasteur Lille; CHU Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Utrecht University; Ruprecht Karls University Heidelberg; German Center for Infection Research; KU Leuven; University of Tokyo; Kyoto University; KU Leuven; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Jagiellonian University; University of Lubeck; German Center for Infection Research; University of Lubeck; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; KU Leuven; Helmholtz Association; German Cancer Research Center (DKFZ); KU Leuven
摘要：The coronavirus membrane protein (M) is the main organizer of coronavirus assembly1, 2-3. Here, we report on an M-targeting molecule, CIM-834, that blocks the assembly of SARS-CoV-2. CIM-834 was obtained through high-throughput phenotypic antiviral screening followed by medicinal-chemistry efforts and target elucidation. CIM-834 inhibits the replication of SARS-CoV-2 (including a broad panel of variants) and SARS-CoV. In SCID mice and Syrian hamsters intranasally infected with SARS-CoV-2, oral...
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作者：Bae, J. Alexander; Baptiste, Mahaly; Baptiste, Maya R.; Bishop, Caitlyn A.; Bodor, Agnes L.; Brittain, Derrick; Brooks, Victoria; Buchanan, Joann; Bumbarger, Daniel J.; Castro, Manuel A.; Celii, Brendan; Cobos, Erick; Collman, Forrest; da Costa, Nuno Macarico; Danskin, Bethanny; Dorkenwald, Sven; Elabbady, Leila; Fahey, Paul G.; Fliss, Tim; Froudarakis, Emmanouil; Gager, Jay; Gamlin, Clare; Gray-Roncal, William; Halageri, Akhilesh; Hebditch, James; Jia, Zhen; Joyce, Emily; Ellis-Joyce, Justin; Jordan, Chris; Kapner, Daniel; Kemnitz, Nico; Kinn, Sam; Kitchell, Lindsey M.; Koolman, Selden; Kuehner, Kai; Lee, Kisuk; Li, Kai; Lu, Ran; Macrina, Thomas; Mahalingam, Gayathri; Matelsky, Jordan; Mcreynolds, Sarah; Miranda, Elanine; Mitchell, Eric; Mondal, Shanka Subhra; Moore, Merlin; Mu, Shang; Muhammad, Taliah; Nehoran, Barak; Neace, Erika; Ogedengbe, Oluwaseun; Papadopoulos, Christos; Papadopoulos, Stelios; Patel, Saumil; Vega, Guadalupe Jovita Yasmin Perez; Pitkow, Xaq; Popovych, Sergiy; Ramos, Anthony; Reid, R. Clay; Reimer, Jacob; Rivlin, Patricia K.; Rose, Victoria; Sauter, Zachary M.; Schneider-Mizell, Casey M.; Seung, H. Sebastian; Silverman, Ben; Silversmith, William; Sterling, Amy; Sinz, Fabian H.; Smith, Cameron L.; Swanstrom, Rachael; Suckow, Shelby; Takeno, Marc; Tan, Zheng H.; Tolias, Andreas S.; Torres, Russel; Turner, Nicholas L.; Walker, Edgar Y.; Wang, Tianyu; Wanner, Adrian; Wester, Brock A.; Williams, Grace; Williams, Sarah; Willie, Kyle; Willie, Ryan; Wong, William; Wu, Jingpeng; Xu, Chris; Yang, Runzhe; Yatsenko, Dimitri; Ye, Fei; Yin, Wenjing; Young, Rob; Yu, Szi-chieh; Xenes, Daniel; Zhang, Chi
作者单位：Princeton University; Princeton University; Baylor College of Medicine; Baylor College of Medicine; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; Allen Institute for Brain Science; Rice University; Princeton University; Foundation for Research & Technology - Hellas (FORTH); Massachusetts Institute of Technology (MIT); Carnegie Mellon University; Carnegie Mellon University; Rice University; Eberhard Karls University of Tubingen; University of Gottingen; Stanford University; Eberhard Karls University of Tubingen; Cornell University; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute
摘要：Understanding the brain requires understanding neurons' functional responses to the circuit architecture shaping them. Here we introduce the MICrONS functional connectomics dataset with dense calcium imaging of around 75,000 neurons in primary visual cortex (VISp) and higher visual areas (VISrl, VISal and VISlm) in an awake mouse that is viewing natural and synthetic stimuli. These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 bill...
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作者：Ibrahim, Mohamed
作者单位：University of Leeds
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作者：Shin, Jaeho; Song, Joseph Woojin; Flavin, Matthew Thomas; Cho, Seunghee; Li, Shupeng; Tan, Ansen; Pyun, Kyung Rok; Huang, Aaron G.; Wang, Huifeng; Jeong, Seongmin; Madsen, Kenneth E.; Trueb, Jacob; Kim, Mirae; Nguyen, Katelynn; Yang, Angela; Hsu, Yaching; Sung, Winnie; Lee, Jiwon; Phyo, Sooyeol; Kim, Ji-Hoon; Banks, Anthony; Chang, Jan-Kai; Paller, Amy S.; Huang, Yonggang; Ameer, Guillermo A.; Rogers, John A.
作者单位：Northwestern University; Korea Institute of Science & Technology (KIST); Northwestern University; Northwestern University; Chan Zuckerberg Initiative (CZI); University System of Georgia; Georgia Institute of Technology; Northwestern University; University of Illinois System; University of Illinois Urbana-Champaign; Northwestern University; Feinberg School of Medicine; Korea Institute of Science & Technology (KIST); Korea Institute of Science & Technology (KIST); Korea University; Kyung Hee University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：Existing wearable technologies rely on physical coupling to the body to establish optical1,2, fluidic3,4, thermal5,6 and/or mechanical7,8 measurement interfaces. Here we present a class of wearable device platforms that instead relies on physical decoupling to define an enclosed chamber immediately adjacent to the skin surface. Streams of vapourized molecular substances that pass out of or into the skin alter the properties of the microclimate defined in this chamber in ways that can be precis...
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作者：Neunuebel, Joshua
作者单位：University of Delaware
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作者：Heidt, Amanda
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作者：Lesbats, Juliette; Brillac, Aurelia; Reisz, Julie A.; Mukherjee, Parnika; Lhuissier, Charlene; Fernandez-Monreal, Monica; Dupuy, Jean-William; Sequeira, Angele; Tioli, Gaia; de la Calle Arregui, Celia; Pinson, Benoit; Wendisch, Daniel; Rousseau, Benoit; Efeyan, Alejo; Sander, Leif Erik; D'Alessandro, Angelo; Garaude, Johan
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; University of Colorado System; University of Colorado Anschutz Medical Campus; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; Universite de Bordeaux; University of Bologna; Centro Nacional de Investigaciones Oncologicas (CNIO); Universite de Bordeaux; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health
摘要：Macrophages specialize in phagocytosis, a cellular process that eliminates extracellular matter, including microorganisms, through internalization and degradation1,2. Despite the critical role of phagocytosis during bacterial infection, the fate of phagocytosed microbial cargo and its impact on the host cell are poorly understood. In this study, we show that ingested bacteria constitute an alternative nutrient source that skews immunometabolic host responses. By tracing stable isotope-labelled...
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作者：Zhao, Han; Shu, Lirong; Qin, Shiyi; Lyu, Fangxuan; Liu, Fuhai; Lin, En; Xia, Sijian; Wang, Baiyue; Wang, Manzhu; Shan, Fengnian; Lin, Yinzhi; Zhang, Lin; Gu, Yufei; Blobel, Gerd A.; Huang, Kai; Zhang, Haoyue
作者单位：Shenzhen Bay Laboratory; Shenzhen Bay Laboratory; Capital Medical University; South China University of Technology; University of Hong Kong; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Shenzhen Medical Academy of Research & Translation (SMART); Southwest University - China
摘要：Mammalian genomes are folded through the distinct actions of structural maintenance of chromosome (SMC) complexes, which include the chromatin loop-extruding cohesin (extrusive cohesin), the sister chromatid cohesive cohesin and the mitotic chromosome-associated condensins1, 2-3. Although these complexes function at different stages of the cell cycle, they exist together on chromatin during the G2-to-M phase transition, when the genome structure undergoes substantial reorganization1,2. Yet, ho...
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作者：Naddaf, Miryam
