作者：Cheng, Lin; Wang, Nan; Bao, Zhigui; Zhou, Qian; Guarracino, Andrea; Yang, Yuting; Wang, Pei; Zhang, Zhiyang; Tang, Die; Zhang, Pingxian; Wu, Yaoyao; Zhou, Yao; Zheng, Yi; Hu, Yong; Lian, Qun; Ma, Zhaoxu; Lassois, Ludivine; Zhang, Chunzhi; Lucas, William J.; Garrison, Erik; Stein, Nils; Staedler, Thomas; Zhou, Yongfeng; Huang, Sanwen
作者单位：Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; University of Liege; Chinese Academy of Tropical Agricultural Sciences; Sun Yat Sen University; University of Tennessee System; University of Tennessee Health Science Center; Yale University; Nanjing Agricultural University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of California System; University of California Davis; Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Martin Luther University Halle Wittenberg; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The tetraploid genome and clonal propagation of the cultivated potato (Solanum tuberosum L.)1,2 dictate a slow, non-accumulative breeding mode of the most important tuber crop. Transitioning potato breeding to a seed-propagated hybrid system based on diploid inbred lines has the potential to greatly accelerate its improvement3. Crucially, the development of inbred lines is impeded by manifold deleterious variants; explaining their nature and finding ways to eliminate them is the current focus ...
作者：Conroy, Gemma
摘要：Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
作者：Coorens, Tim H. H.; Collord, Grace; Jung, Hyungchul; Wang, Yichen; Moore, Luiza; Hooks, Yvette; Mahbubani, Krishnaa; Law, Simon Y. K.; Yan, Helen H. N.; Yuen, Siu Tsan; Saeb-Parsy, Kourosh; Campbell, Peter J.; Martincorena, Inigo; Leung, Suet Yi; Stratton, Michael R.
作者单位：Wellcome Trust Sanger Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of Cambridge; University of Cambridge; University of Hong Kong; University of Hong Kong; Hong Kong St. Paul's Hospital; University of Cambridge
摘要：The landscapes of somatic mutation in normal cells inform us about the processes of mutation and selection operative throughout life, providing insight into normal ageing and the earliest stages of cancer development1. Here, by whole-genome sequencing of 238 microdissections2 from 30 individuals, including 18 with gastric cancer, we elucidate the developmental trajectories of normal and malignant gastric epithelium. We find that gastric glands are units of monoclonal cell populations that accr...
