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作者：Donado, Carlos A.; Theisen, Erin; Zhang, Fan; Nathan, Aparna; Fairfield, Madison L.; Rupani, Karishma Vijay; Jones, Dominique; Johannes, Kellsey P.; Accelerating Med Partnership RA SLE Network, Christopher; Raychaudhuri, Soumya; Dwyer, Daniel F.; Jonsson, A. Helena; Brenner, Michael B.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Colorado System; University of Colorado Anschutz Medical Campus; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
摘要：Granzymes are a family of serine proteases that are mainly expressed by CD8+ T cells, natural killer cells and innate-like lymphocytes1. Although their primary function is thought to be the induction of cell death in virally infected cells and tumours, accumulating evidence indicates that some granzymes can elicit inflammation by acting on extracellular substrates1. We previously found that most tissue CD8+ T cells in rheumatoid arthritis synovium, and in inflamed organs for some other disease...
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作者：Sun, Yusha; Wang, Xin; Zhang, Daniel Y.; Zhang, Zhijian; Bhattarai, Janardhan P.; Wang, Yingqi; Park, Kristen H.; Dong, Weifan; Hung, Yun-Fen; Yang, Qian; Zhang, Feng; Rajamani, Keerthi; Mu, Shang; Kennedy, Benjamin C.; Hong, Yan; Galanaugh, Jamie; Sambangi, Abhijeet; Kim, Sang Hoon; Wheeler, Garrett; Goncalves, Tiago; Wang, Qing; Geschwind, Daniel H.; Kawaguchi, Riki; Viaene, Angela N.; Helbig, Ingo; Kessler, Sudha K.; Hoke, Ahmet; Wang, Huadong; Xu, Fuqiang; Binder, Zev A.; Isaac Chen, H.; Pai, Emily Ling-Lin; Stone, Sara; Nasrallah, MacLean P.; Christian, Kimberly M.; Fuccillo, Marc; Toni, Nicolas; Wu, Zhuhao; Cheng, Hwai-Jong; O'Rourke, Donald M.; Ma, Minghong; Ming, Guo-li; Song, Hongjun
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Academia Sinica - Taiwan; Cornell University; Weill Cornell Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Thomas Jefferson University; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Johns Hopkins University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Glioblastoma (GBM) infiltrates the brain and can be synaptically innervated by neurons, which drives tumour progression1,2. Synaptic inputs onto GBM cells identified so far are largely short range and glutamatergic3,4. The extent of GBM integration into the brain-wide neuronal circuitry remains unclear. Here we applied rabies virus-mediated and herpes simplex virus-mediated trans-monosynaptic tracing5,6 to systematically investigate circuit integration of human GBM organoids transplanted into ...
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作者：Marchant, Jo
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作者：[Anonymous]
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作者：Xiang, Yutong; Wang, Chong; Liu, Chunsen; Wang, Tanjun; Jiang, Yongbo; Wang, Yang; Wang, Shuiyuan; Zhou, Peng
作者单位：Fudan University
摘要：The pursuit of non-volatile memory with program speeds below one nanosecond, beyond the capabilities of non-volatile flash and high-speed volatile static random-access memory, remains a longstanding challenge in the field of memory technology1. Utilizing fundamental physics innovation enabled by advanced materials, series of emerging memories2, 3, 4-5 are being developed to overcome the speed bottleneck of non-volatile memory. As the most extensively applied non-volatile memory, the speed of f...
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作者：Mallapaty, Smriti
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作者：Qiu, Jian-Xiang; Ghosh, Barun; Schutte-Engel, Jan; Qian, Tiema; Smith, Michael; Yao, Yueh-Ting; Ahn, Junyeong; Liu, Yu-Fei; Gao, Anyuan; Tzschaschel, Christian; Li, Houchen; Petrides, Ioannis; Berube, Damien; Dinh, Thao; Huang, Tianye; Liebman, Olivia; Been, Emily M.; Blawat, Joanna M.; Watanabe, Kenji; Taniguchi, Takashi; Fong, Kin Chung; Lin, Hsin; Orth, Peter P.; Narang, Prineha; Felser, Claudia; Chang, Tay-Rong; Mcdonald, Ross; Mcqueeney, Robert J.; Bansil, Arun; Martin, Ivar; Ni, Ni; Ma, Qiong; Marsh, David J. E.; Vishwanath, Ashvin; Xu, Su-Yang
作者单位：Harvard University; Northeastern University; Northeastern University; Department of Science & Technology (India); SN Bose National Centre for Basic Science (SNBNCBS); University of California System; University of California Berkeley; University of California System; University of California Los Angeles; United States Department of Energy (DOE); Argonne National Laboratory; National Cheng Kung University; Harvard University; University of Zurich; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; United States Department of Energy (DOE); Los Alamos National Laboratory; National Institute for Materials Science; Northeastern University; Academia Sinica - Taiwan; Iowa State University; United States Department of Energy (DOE); Ames National Laboratory; Saarland University; University of California System; University of California Los Angeles; Max Planck Society; Boston College; Boston College; University of London; King's College London
摘要：The axion is a hypothetical fundamental particle that is conjectured to correspond to the coherent oscillation of the theta field in quantum chromodynamics1,2. Its existence would solve multiple fundamental questions, including the strong CP problem of quantum chromodynamics and dark matter, but the axion has never been detected. Electrodynamics of condensed-matter systems can also give rise to a similar theta, so far studied as a static, quantized value to characterize the topology of materia...
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作者：Prendergast, Mary
作者单位：Rice University
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作者：Ahmadlou, Mehran; Shirazi, Maryam Yasamin; Zhang, Pan; Rogers, Isaac L. M.; Dziubek, Julia; Young, Margaret; Hofer, Sonja B.
作者单位：University of London; University College London
摘要：To survive in dynamic environments with uncertain resources, animals must adapt their behaviour flexibly, choosing strategies such as persevering with a current choice, exploring alternatives or disengaging altogether. Previous studies have mainly investigated how forebrain regions represent choice costs and values as well as optimal strategies during such decisions1, 2, 3, 4-5. However, the neural mechanisms by which the brain implements alternative behavioural strategies such as persevering,...
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作者：Bhambra, Raveena
