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作者：Kazakov, Dmitry; Letsou, Theodore P.; Piccardo, Marco; Columbo, Lorenzo L.; Brambilla, Massimo; Prati, Franco; Dal Cin, Sandro; Beiser, Maximilian; Opacak, Nikola; Ratra, Pawan; Pushkarsky, Michael; Caffey, David; Day, Timothy; Lugiato, Luigi A.; Schwarz, Benedikt; Capasso, Federico
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Universidade de Lisboa; Polytechnic University of Turin; Politecnico di Bari; University of Insubria; Technische Universitat Wien; Imperial College London; Interuniversity Microelectronics Centre
摘要：Despite the continuing progress in integrated optical frequency comb technology1, compact sources of short, bright pulses in the mid-infrared wavelength range from 3 to 12 mu m so far remain beyond reach. The state-of-the-art ultrafast pulse emitters in the mid-infrared are complex, bulky and inefficient systems based on the downconversion of near-infrared or visible pulsed laser sources. Here we show a purely DC-driven semiconductor laser chip that generates 1-ps solitons at the centre wavele...
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作者：Grosskopf, Johannes; Gopatta, Chawanansaya; Martin, Robert T.; Haseloer, Alexander; Macmillan, David W. C.
作者单位：Princeton University
摘要：The efficient and modular diversification of molecular scaffolds, particularly for the synthesis of diverse molecular libraries, remains a notable challenge in drug optimization campaigns1, 2-3. The late-stage introduction of alkyl fragments is especially desirable due to the high sp3 character and structural versatility of these motifs4. Given their prevalence in molecular frameworks, C(sp2)-H bonds serve as attractive targets for diversification, although this process often requires difficul...
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作者：Ambrose, Kristal K.; Walker, Tony R.
作者单位：Dalhousie University
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作者：Scerri, Eleanor M. L.; Blinkhorn, James; Groucutt, Huw S.; Stewart, Mathew; Candy, Ian; Allue, Ethel; Burguet-Coca, Aitor; Curras, Andres; Carleton, W. Christopher; Lindauer, Susanne; Spengler, Robert; Boxleitner, Kseniia; Asciak, Gillian; Colucci, Margherita; Gauci, Ritienne; Hatton, Amy; Kutowsky, Johanna; Maier, Andreas; Mata-Gonzalez, Mario; Mifsud, Nicolette; Niang, Khady; Roberts, Patrick; de Giorgio, Joshua; Xerri, Rochelle; Vella, Nicholas C.
作者单位：Max Planck Society; University of Malta; University of Cologne; University of Liverpool; Griffith University; University of London; Royal Holloway University London; Universitat Rovira i Virgili; Leiden University - Excl LUMC; Leiden University; Max Planck Society; Max Planck Society; University of Cambridge; University of Malta; Max Planck Society; Eberhard Karls University of Tubingen; University Cheikh Anta Diop Dakar; Max Planck Society; University of York - UK
摘要：The Maltese archipelago is a small island chain that is among the most remote in the Mediterranean. Humans were not thought to have reached and inhabited such small and isolated islands until the regional shift to Neolithic lifeways, around 7.5 thousand years ago (ka)1. In the standard view, the limited resources and ecological vulnerabilities of small islands, coupled with the technological challenges of long-distance seafaring, meant that hunter-gatherers were either unable or unwilling to m...
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作者：Liang, Jiaming; Shi, Junhui; Song, Ailong; Lu, Meihua; Zhang, Kairan; Xu, Meng; Huang, Gaoxingyu; Lu, Peilong; Wu, Xudong; Ma, Dan
作者单位：Fudan University; Westlake University; Westlake Laboratory; Westlake University
摘要：The mitochondrial pyruvate carrier (MPC) is a mitochondrial inner membrane protein complex that is essential for the uptake of pyruvate into the mitochondrial matrix as the primary carbon source for the tricarboxylic acid cycle1,2. Here we present six cryo-electron microscopy structures of human MPC in three states: three structures in the intermembrane space (IMS)-open state, obtained in different conditions; a structure of pyruvate-treated MPC in the occluded state; and two structures in the...
