作者：Toh, Pamela; Rajbhandari, Abha Karki
作者单位：Icahn School of Medicine at Mount Sinai
作者：Sawamoto, Nobukatsu; Doi, Daisuke; Nakanishi, Etsuro; Sawamura, Masanori; Kikuchi, Takayuki; Yamakado, Hodaka; Taruno, Yosuke; Shima, Atsushi; Fushimi, Yasutaka; Okada, Tomohisa; Kikuchi, Tetsuhiro; Morizane, Asuka; Hiramatsu, Satoe; Anazawa, Takayuki; Shindo, Takero; Ueno, Kentaro; Morita, Satoshi; Arakawa, Yoshiki; Nakamoto, Yuji; Miyamoto, Susumu; Takahashi, Ryosuke; Takahashi, Jun
作者单位：Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kyoto University
摘要：Parkinson's disease is caused by the loss of dopamine neurons, causing motor symptoms. Initial cell therapies using fetal tissues showed promise but had complications and ethical concerns1, 2, 3, 4-5. Pluripotent stem (PS) cells emerged as a promising alternative for developing safe and effective treatments6. In this phase I/II trial at Kyoto University Hospital, seven patients (ages 50-69) received bilateral transplantation of dopaminergic progenitors derived from induced PS (iPS) cells. Prim...
作者：Fisher, Deanne
作者单位：Swinburne University of Technology
作者：van Vuuren, Detlef P.; Doelman, Jonathan C.; Tagomori, Isabela Schmidt; Beusen, Arthur H. W.; Cornell, Sarah E.; Rockstrom, Johan; Schipper, Aafke M.; Stehfest, Elke; Ambrosio, Geanderson; van den Berg, Maarten; Bouwman, Lex; Daioglou, Vassilis; Harmsen, Mathijs; Lucas, Paul; van der Wijst, Kaj-Ivar; van Zeist, Willem-Jan
作者单位：Utrecht University; Utrecht University; Stockholm University; Potsdam Institut fur Klimafolgenforschung; University of Potsdam; Radboud University Nijmegen; Wageningen University & Research
摘要：The pressures humanity has been placing on the environment have put Earth's stability at risk. The planetary boundaries framework serves as a method to define a 'safe operating space for humanity'1,2 and has so far been applied mostly to highlight the currently prevailing unsustainable environmental conditions. The ability to evaluate trends over time, however, can help us explore the consequences of alternative policy decisions and identify pathways for living within planetary boundaries3. He...
作者：Fisher, Deanne
作者单位：Swinburne University of Technology
