8064期

最新文章

• Large gas inflow driven by a matured galactic bar in the early Universe AI翻译
  作者：Huang, Shuo; Kawabe, Ryohei; Umehata, Hideki; Kohno, Kotaro; Tamura, Yoichi; Saito, Toshiki
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); Nagoya University; Graduate University for Advanced Studies - Japan; Nagoya University; University of Tokyo; University of Tokyo; Shizuoka University
  摘要：Bar structures are present in about half of local disk galaxies(1) and play pivotal roles in secular galaxy evolution. Bars impose a non-axisymmetric perturbation on the rotating disk and transport gas inwards to feed the central starburst and, possibly, the activity of the nuclear supermassive black hole(2). They are believed to be long-lived structures(3,4) and are now identified at redshift z > 2 (refs. (5,6)). However, little is known about the onset and effects of bars in the early cosmic...
• Are groundbreaking science discoveries becoming harder to find? AI翻译
  作者：Matthews, David
• Atacama sunshine helps to pull water from thin air AI翻译
  作者：[Anonymous]
• Cold memories control whole-body thermoregulatory responses AI翻译
  作者：Munoz Zamora, Andrea; Douglas, Aaron; Conway, Paul B.; Urrieta, Esteban; Moniz, Taylor; O'Leary, James D.; Marks, Lydia; Denny, Christine A.; Ortega-de San Luis, Clara; Lynch, Lydia; Ryan, Tomas J.
  作者单位：Trinity College Dublin; Trinity College Dublin; Allen Institute for Brain Science; New York State Psychiatry Institute; Universidad de Jaen; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Princeton University; Princeton University; Florey Institute of Neuroscience & Mental Health; University of Melbourne; Canadian Institute for Advanced Research (CIFAR)
  摘要：Environmental thermal challenges trigger the brain to coordinate both autonomic and behavioural responses to maintain optimal body temperature1, 2, 3-4. It is unknown how temperature information is precisely stored and retrieved in the brain and how it is converted into a physiological response. Here we investigated whether memories could control whole-body metabolism by training mice to remember a thermal challenge. Mice were conditioned to associate a context with a specific temperature by c...
• A prospective code for value in the serotonin system AI翻译
  作者：Harkin, Emerson F.; Grossman, Cooper D.; Cohen, Jeremiah Y.; Beique, Jean-Claude; Naud, Richard
  作者单位：University of Ottawa; University of Ottawa; University of Ottawa; California Institute of Technology; Johns Hopkins University; University of Ottawa; Max Planck Society
  摘要：The in vivo responses of dorsal raphe nucleus serotonin neurons to emotionally salient stimuli are a puzzle1. Existing theories centring on reward2, surprise3, salience4 and uncertainty5 individually account for some aspects of serotonergic activity but not others. Merging ideas from reinforcement learning theory6 with recent insights into the filtering properties of the dorsal raphe nucleus7, here we find a unifying perspective in a prospective code for value. This biological code for near-fu...
• #OpenToWork: how laid-off US scientists are coping with shattered careers AI翻译
  作者：Gewin, Virginia
• A 'hidden gem' of the Amazon is a frog with odd habits AI翻译
  作者：[Anonymous]
• Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines AI翻译
  作者：Krawczyk, Pawel S.; Mazur, Michal; Orzel, Wiktoria; Gewartowska, Olga; Jelen, Sebastian; Antczak, Wiktor; Kasztelan, Karolina; Brouze, Aleksandra; Matylla-Kulinska, Katarzyna; Guminska, Natalia; Tarkowski, Bartosz; Owczarek, Ewelina P.; Affek, Kamila; Turowski, Pawel; Tudek, Agnieszka; Sroka, Malgorzata; Spiewla, Tomasz; Kusio-Kobialka, Monika; Wesolowska, Aleksandra; Nowis, Dominika; Golab, Jakub; Kowalska, Joanna; Jemielity, Jacek; Dziembowski, Andrzej; Mroczek, Seweryn
  作者单位：Miedzynarodowy Instytut Biologii Molekularnej i Komorkowej; University of Warsaw; Miedzynarodowy Instytut Biologii Molekularnej i Komorkowej; Polish Academy of Sciences; Institute of Biochemistry & Biophysics - Polish Academy of Sciences; Miedzynarodowy Instytut Biologii Molekularnej i Komorkowej; University of Warsaw; Medical University of Warsaw; Medical University of Warsaw; Medical University of Warsaw; University of Warsaw; University of Warsaw
  摘要：Despite the widespread use of mRNA vaccines against COVID-19, little is known about the metabolism of therapeutic RNAs. Here we use nanopore sequencing1, 2-3 to analyse individual therapeutic mRNA molecules, focusing on their poly(A) tails. We show that the Moderna mRNA-1273 vaccine4 has a poly(A) tail of around 100 nucleotides, followed by an m Psi Cm Psi AG sequence. In cell lines, mRNA-1273 undergoes rapid degradation initiated by m Psi Cm Psi AG removal, followed by CCR4-NOT-mediated deade...
• 'AI models are capable of novel research': OpenAI's chief scientist on what to expect AI翻译
  作者：Gibney, Elizabeth
• Heart-attack outcomes are worse in the morning when activity of protein duo dips AI翻译
  作者：Kupai, Ariana; Peek, Clara
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine