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作者：Hauseman, Zachary J.; Stauffer, Frederic; Beyer, Kim S.; Molle, Sandra; Cavicchioli, Elena; Marchand, Jean-Remy; Fodor, Michelle; Viscomi, Jessica; Dhembi, Anxhela; Katz, Stephanie; Faggion, Beatrice; Lanter, Mylene; Kerr, Grainne; Schildknecht, Daniela; Handl, Cornelia; Maddalo, Danilo; Soldermann, Carole Pissot; Brady, Jacob; Shrestha, Om; Nguyen, Zachary; Leder, Lukas; Cremosnik, Gregor; Romero, Sandra Lopez; Hassiepen, Ulrich; Stams, Travis; Linder, Markus; Galli, Giorgio G.; Guthy, Daniel A.; King, Daniel A.; Maira, Sauveur-Michel; Thoma, Claudio R.; Ehmke, Veronika; Tordella, Luca
作者单位：Novartis; Novartis USA; Novartis
摘要：Activating mutations in the rat sarcoma (RAS) genes HRAS, NRAS and KRAS collectively represent the most frequent oncogenic driver in human cancer1. They have previously been considered undruggable, but advances in the past few years have led to the clinical development of agents that target KRAS(G12C) and KRAS(G12D) mutants, yielding promises of therapeutic responses at tolerated doses2. However, clinical agents that selectively target NRAS(Q61*) mutants (* represents 'any'), the second-most-f...
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作者：Sun, Wenfei; Liu, Zhihui; Jiang, Xian; Chen, Michelle B.; Dong, Hua; Liu, Jonathan; Sudhof, Thomas C.; Quake, Stephen R.
作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
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作者：Lavoie, Hugo; Therrien, Marc
作者单位：Universite de Montreal
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作者：Lenharo, Mariana
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作者：Pei, Guangsheng; Min, Jimin; Rajapakshe, Kimal I.; Branchi, Vittorio; Liu, Yunhe; Selvanesan, Benson Chellakkan; Thege, Fredrik; Sadeghian, Dorsay; Zhang, Daiwei; Cho, Kyung Serk; Chu, Yanshuo; Dai, Enyu; Han, Guangchun; Li, Mingyao; Yee, Cassian; Takahashi, Kazuki; Garg, Bharti; Tiriac, Herve; Bernard, Vincent; Semaan, Alexander; Grem, Jean L.; Caffrey, Thomas C.; Burks, Jared K.; Lowy, Andrew M.; Aguirre, Andrew J.; Grandgenett, Paul M.; Hollingsworth, Michael A.; Guerrero, Paola A.; Wang, Linghua; Maitra, Anirban
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Pennsylvania; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Diego; University of Texas System; UTMD Anderson Cancer Center; University of Bonn; University of Nebraska System; University of Nebraska Medical Center; University of Nebraska System; University of Nebraska Medical Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
摘要：Patients with treatment-refractory pancreatic cancer often succumb to systemic metastases1, 2-3; however, the transcriptomic heterogeneity that underlies therapeutic recalcitrance remains understudied, particularly in a spatial context. Here we construct high-resolution maps of lineage states, clonal architecture and the tumour microenvironment (TME) using spatially resolved transcriptomics from 55 samples of primary tumour and metastases (liver, lung and peritoneum) collected from rapid autop...
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作者：Li, Rongkang; Peng, Lei; Zhang, Shaohua; Wu, Song
作者单位：Shenzhen University
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作者：Mukamel, Eran A.; Yu, Zhaoxia
作者单位：University of California System; University of California San Diego; University of California System; University of California Irvine
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作者：Smith, Holly
摘要：In warming coastal seas, a crucial ecosystem is being replaced by 'turfs' of red algae, which release chemicals that suppress kelp survival.
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作者：Jones, Daniel O. B.; Arias, Maria Belen; Van Audenhaege, Loic; Blackbird, Sabena; Boolukos, Corie; Bribiesca-Contreras, Guadalupe; Copley, Jonathan T.; Dale, Andrew; Evans, Susan; Fleming, Bethany F. M.; Gates, Andrew R.; Grant, Hannah; Hartl, Mark G. J.; Huvenne, Veerle A. I.; Jeffreys, Rachel M.; Josso, Pierre; King, Lucas D.; Simon-Lledo, Erik; Le Bas, Tim; Norman, Louisa; O'Malley, Bryan; Peacock, Thomas; Shimmield, Tracy; Stewart, Eva C. D.; Sweetman, Andrew K.; Wardell, Catherine; Aleynik, Dmitry; Glover, Adrian G.
作者单位：University of Southampton; NERC National Oceanography Centre; Natural History Museum London; University of Liverpool; University of Southampton; University of the Highlands & Islands; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Heriot Watt University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); CSIC - Instituto de Ciencias del Mar (ICM); Massachusetts Institute of Technology (MIT)
摘要：Deep-sea polymetallic nodule mining is in the exploration phase at present with some groups proposing a move towards extraction within years1. Management of this industry requires evidence of the long-term effects on deep-sea ecosystems2, but the ability of seafloor ecosystems to recover from impacts over decadal scales is poorly understood3. Here we show that, four decades after a test mining experiment that removed nodules, the biological impacts in many groups of organisms are persistent, a...
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作者：Gueye, Gaoussou
