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作者：Conroy, Gemma
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作者：Liao, Meimei; Liu, Yanqin; Xu, Zhancong; Fang, Mingxu; Yu, Ziqing; Cui, Yufan; Sun, Zhengda; Huo, Ran; Yang, Jieyu; Huang, Fusheng; Liu, Mingming; Zhou, Qin; Song, Xiaocui; Han, Hui; Chen, She; Xu, Xiaodong; Qin, Ximing; He, Qun; Ju, Dapeng; Wang, Tao; Thakkar, Nirav; Hardin, Paul E.; Golden, Susan S.; Zhang, Eric Erquan
作者单位：National Institute of Biological Sciences, Beijing; Tsinghua University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; University of California System; University of California San Diego; Tsinghua University; China Agricultural University; Henan University; Anhui University; Chongqing Medical University; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; University of California System; University of California San Diego
摘要：The eukaryotic circadian clock keeps time by using a transcription-translation feedback loop, which exhibits an architecture that is conserved across a diverse range of organisms, including fungi, plants and animals1. Despite their mechanistic similarity, the molecular components of these clocks indicate a lack of common ancestry2. Our study reveals that RUVBL2, which is a P-loop NTPase enzyme previously shown to affect circadian phase and amplitude as part of mammalian clock super-complexes, ...
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作者：[Anonymous]
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作者：Schaffer, Leah V.; Hu, Mengzhou; Qian, Gege; Moon, Kyung-Mee; Pal, Abantika; Soni, Neelesh; Latham, Andrew P.; Vaites, Laura Pontano; Tsai, Dorothy; Mattson, Nicole M.; Licon, Katherine; Bachelder, Robin; Cesnik, Anthony; Gaur, Ishan; Le, Trang; Leineweber, William; Palar, Aji; Pulido, Ernst; Qin, Yue; Zhao, Xiaoyu; Churas, Christopher; Lenkiewicz, Joanna; Chen, Jing; Ono, Keiichiro; Pratt, Dexter; Zage, Peter; Echeverria, Ignacia; Sali, Andrej; Harper, J. Wade; Gygi, Steven P.; Foster, Leonard J.; Huttlin, Edward L.; Lundberg, Emma; Ideker, Trey
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of British Columbia; University of California System; University of California San Francisco; Harvard University; Harvard Medical School; Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Diego; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford University; Royal Institute of Technology; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Human cells consist of a complex hierarchy of components, many of which remain unexplored1,2. Here we construct a global map of human subcellular architecture through joint measurement of biophysical interactions and immunofluorescence images for over 5,100 proteins in U2OS osteosarcoma cells. Self-supervised multimodal data integration resolves 275 molecular assemblies spanning the range of 10-8 to 10-5 m, which we validate systematically using whole-cell size-exclusion chromatography and ann...
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作者：Tollefson, Jeff; Garisto, Dan
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作者：Li, Li
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
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作者：Kim, Ji-il; Imaizumi, Kent; Jurjut, Ovidiu; Kelley, Kevin W.; Wang, Dong; Thete, Mayuri Vijay; Hudacova, Zuzana; Amin, Neal D.; Levy, Rebecca J.; Scherrer, Gregory; Pasca, Sergiu P.
作者单位：Stanford University; Stanford University; University of North Carolina; University of North Carolina Chapel Hill
摘要：Somatosensory pathways convey crucial information about pain, touch, itch and body part movement from peripheral organs to the central nervous system1,2. Despite substantial needs to understand how these pathways assemble and to develop pain therapeutics, clinical translation remains challenging. This is probably related to species-specific features and the lack of in vitro models of the polysynaptic pathway. Here we established a human ascending somatosensory assembloid (hASA), a four-part as...
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作者：Chow, S. Lin Er; Luo, Zhaoyang; Ariando, A.
作者单位：National University of Singapore
摘要：The discovery of superconductivity in the Ba-La-Cu-O system (the cuprate) in the 30 K range marked a significant breakthrough, which inspired extensive exploration of oxide-based, layered superconductors to identify electron pairing with higher critical temperatures (Tc)1. Despite recent observations of superconductivity in nickel oxide-based compounds (the nickelates), evidence of Cooper pairing above 30 K in a system that is isostructural to the cuprates, but without copper, at ambient press...
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作者：Garisto, Dan
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作者：Sun, Jiawei; He, Jiayan; Massaro, Luca; Cagan, David A.; Tsien, Jet; Wang, Yu; Attard, Flynn C.; Smith, Jillian E.; Lee, Jason S.; Kawamata, Yu; Baran, Phil S.
作者单位：Scripps Research Institute; Scripps Research Institute
摘要：Free radicals were first discovered more than 120 years ago by Gomberg1 and the first radical cross-couplings demonstrated by Kochi in the 1970s (ref. 2). In contrast to widely used polar cross-coupling chemistry to forge C(sp2)-C(sp2) bonds (such as Suzuki, Negishi and Kumada), radical cross-coupling is advantageous when applied to the coupling of saturated systems because of the mild conditions used and enhanced chemoselectivity associated with single-electron chemistry. The ability to use u...
