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作者：Vinayagam, Deivanayagabarathy; Sitsel, Oleg; Schulte, Uwe; Constantin, Cristina E.; Oosterheert, Wout; Prumbaum, Daniel; Zolles, Gerd; Fakler, Bernd; Raunser, Stefan
作者单位：Max Planck Society; University of Freiburg; Okinawa Institute of Science & Technology Graduate University
摘要：Tight control of intracellular Ca2+ levels is fundamental as they are used to control numerous signal transduction pathways1. Plasma membrane Ca2+-ATPases (PMCAs) have a crucial role in this process by extruding Ca2+ against a steep concentration gradient from the cytosol to the extracellular space2. Although new details of PMCA biology are constantly being uncovered, the structural basis of the most distinguishing features of these pumps, namely, transport rates in the kilohertz range and reg...
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作者：Yu, Guang; Xu, Kai; Xia, Weikun; Zhang, Ke; Xu, Qianhua; Li, Lijia; Lin, Zili; Liu, Ling; Liu, Bofeng; Du, Zhenhai; Chen, Xia; Fan, Qiang; Lai, Fangnong; Wang, Wenying; Wang, Lijuan; Kong, Feng; Wang, Chao; Dai, Haiqiang; Wang, Huili; Xie, Wei
作者单位：Tsinghua University; Tsinghua University; Beijing University of Agriculture; Tsinghua University; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Jiangsu Academy of Agricultural Sciences
摘要：After fertilization, early embryos undergo dissolution of conventional chromatin organization, including topologically associating domains (TADs)1,2. Zygotic genome activation then commences amid unusually slow de novo establishment of three-dimensional chromatin architecture2. How chromatin organization is established and how it interplays with transcription in early mammalian embryos remain elusive. Here we show that CTCF occupies chromatin throughout mouse early development. By contrast, co...
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作者：Almeida, Abilio
作者单位：Universidade do Minho
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作者：Leeming, Jack
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作者：Baglaenko, Yuriy; Mu, Zepeng; Curtis, Michelle; Mire, Hafsa M.; Jayanthi, Vidyashree; Al Suqri, Majd; Liu, Cassidy; Agnew, Ryan; Nathan, Aparna; Mah-Som, Annelise Yoo; Liu, David R.; Newby, Gregory A.; Raychaudhuri, Soumya
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Howard Hughes Medical Institute; Harvard Medical School; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University
摘要：Genetic studies have identified thousands of individual disease-associated non-coding alleles, but the identification of the causal alleles and their functions remains a critical bottleneck(1). CRISPR-Cas editing has enabled targeted modification of DNA to introduce and test disease alleles. However, the combination of inefficient editing, heterogeneous editing outcomes in individual cells and nonspecific transcriptional changes caused by editing and culturing conditions limits the ability to ...
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作者：Kobis, Nils; Rahwan, Zoe; Rilla, Raluca; Supriyatno, Bramantyo Ibrahim; Bersch, Clara; Ajaj, Tamer; Bonnefon, Jean-Francois; Rahwan, Iyad
作者单位：University of Duisburg Essen; Max Planck Society; Max Planck Society; Communaute d'universites et etablissements de Toulouse (Comue); Universite Toulouse 1 Capitole; Toulouse School of Economics
摘要：Although artificial intelligence enables productivity gains from delegating tasks to machines1, it may facilitate the delegation of unethical behaviour2. This risk is highly relevant amid the rapid rise of 'agentic' artificial intelligence systems3,4. Here we demonstrate this risk by having human principals instruct machine agents to perform tasks with incentives to cheat. Requests for cheating increased when principals could induce machine dishonesty without telling the machine precisely what...
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作者：Zhao, Arthur; Gruntman, Eyal; Nern, Aljoscha; Iyer, Nirmala; Rogers, Edward M.; Koskela, Sanna; Siwanowicz, Igor; Dreher, Marisa; Flynn, Miriam A.; Laughland, Connor; Ludwig, Henrique; Thomson, Alexander; Moran, Cullen; Gezahegn, Bruck; Bock, Davi D.; Reiser, Michael B.
作者单位：Howard Hughes Medical Institute; University of Vermont
摘要：Many animals use vision to navigate their environment. The pattern of changes that self-motion induces in the visual scene, referred to as optic flow1, is first estimated in local patches by directionally selective neurons2, 3-4. However, how arrays of directionally selective neurons, each responsive to motion in a preferred direction at specific retinal positions, are organized to support robust decoding of optic flow by downstream circuits is unclear. Understanding this global organization r...
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作者：Mckie, Anna
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作者：Wu, Weijie; Davis, Emily J.; Hughes, Lillian B.; Ye, Bingtian; Wang, Zilin; Kufel, Dominik; Ono, Tasuku; Meynell, Simon A.; Block, Maxwell; Liu, Che; Yang, Haopu; Jayich, Ania C. Bleszynski; Yao, Norman Y.
作者单位：Harvard University; New York University; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
摘要：Spin-squeezed states provide a seminal example of how the structure of quantum mechanical correlations can be controlled to produce metrologically useful entanglement1, 2, 3, 4, 5, 6-7. These squeezed states have been demonstrated in a wide variety of quantum systems ranging from atoms in optical cavities to trapped ion crystals8, 9, 10, 11, 12, 13, 14, 15-16. By contrast, despite their numerous advantages as practical sensors, spin ensembles in solid-state materials have yet to be controlled ...
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作者：[Anonymous]
