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作者：[Anonymous]
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作者：Mahmoudi, Soheil; Gruene, Tim; Schroeder, Christian; Ferjaoui, Khalil D.; Frojdh, Erik; Mozzanica, Aldo; Takaba, Kiyofumi; Volkov, Anatoliy; Maisriml, Julian; Paunovic, Vladimir; van Bokhoven, Jeroen A.; Keppler, Bernhard K.
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作者：Jacobs, Jean; Lyubenova, Hristiana; Potelle, Sven; Kopp, Johannes; Gerin, Isabelle; Chan, Wing Lee; Rodriguez de los Santos, Miguel; Hulsemann, Wiebke; Mensah, Martin A.; Cormier-Daire, Valerie; Joosten, Marieke; Bruggenwirth, Hennie T.; Stuurman, Kyra E.; Miranda, Valancy; Campeau, Philippe M.; Wittler, Lars; Graff, Julie; Mundlos, Stefan; Ibrahim, Daniel M.; Van Schaftingen, Emile; Fischer-Zirnsak, Bjorn; Kornak, Uwe; Ehmke, Nadja; Bommer, Guido T.
作者单位：Universite Catholique Louvain; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Max Planck Society; Free University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Icahn School of Medicine at Mount Sinai; University of Hamburg; University Medical Center Hamburg-Eppendorf; Helios Kliniken; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Erasmus University Rotterdam; Erasmus MC; Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine; University of Gottingen; University of Gottingen Hospital; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health
摘要：Living cells depend on an intricate network of chemical reactions catalysed by enzymes, which sometimes make mistakes that lead to their inactivation. Here we report a metabolite-based mechanism for preserving enzyme function in an unfavourable environment. We found that the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, a mimic of the reaction intermediate of the enzyme UXS1, which regenerates the essential cofactor NAD+ within the catalytic pocket of UXS1 by completing its catalytic cycle. ...
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作者：Selvitella, Alessandro Maria; Foster, Kathleen Lois
作者单位：Purdue University System; Purdue University; Indiana University Purdue University Fort Wayne; Ball State University
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作者：[Anonymous]
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作者：Suzuki, Shoko
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作者：Pawlik, Piotr; Grigoriadis, Kristiana; Bunkum, Abigail; Coggan, Helena; Frankell, Alexander M.; Martinez-Ruiz, Carlos; Karasaki, Takahiro; Huebner, Ariana; Rowan, Andrew; Fisher, Jasmin; Hackshaw, Allan; Swanton, Charles; Zaccaria, Simone; McGranahan, Nicholas
作者单位：University of London; Cancer Research UK; University College London; University of London; University College London; Francis Crick Institute; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of Cambridge; University of Tokyo; Cancer Research UK; University of London; University College London; University of London; University College London Hospitals NHS Foundation Trust; University College London
摘要：Both single nucleotide variants (SNVs) and somatic copy number alterations (SCNAs) accumulate in cancer cells during tumour development, fuelling clonal evolution. However, accurate estimation of clone-specific copy numbers from bulk DNA-sequencing data is challenging. Here we present allele-specific phylogenetic analysis of copy number alterations (ALPACA), a method to infer SNV and SCNA coevolution by leveraging phylogenetic trees reconstructed from multi-sample bulk tumour sequencing data u...
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作者：Gao, Haoyang; Martin, Leigh S.; Hughes, Lillian B.; Leitao, Nathaniel T.; Put, Piotr; Zhou, Hengyun; Koyluoglu, Nazli U.; Meynell, Simon A.; Jayich, Ania C. Bleszynski; Park, Hongkun; Lukin, Mikhail D.
作者单位：Harvard University; University of California System; University of California Santa Barbara; Harvard University; University of California System; University of California Santa Barbara; Harvard University
摘要：Electronic spins of nitrogen-vacancy centres in diamond constitute a promising system for micro- and nanoscale magnetic sensing1, 2, 3-4, because of their operation under ambient conditions5, ease of placement in close proximity to sensing targets6 and biological compatibility7. At high densities, the electronic spins interact through dipolar coupling, which typically limits8 but can also potentially enhance9 sensing performance. Here we report the experimental demonstration of many-body signa...
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作者：Lenharo, Mariana
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作者：McKie, Anna
