2025

最新文章

• Subnucleosome preference of human chromatin remodeller SMARCAD1 AI翻译
  作者：Hu, Pengjing; Sun, Jingxi; Sun, Hongyao; Chen, Kangjing; Sia, Youyang; Xia, Xian; Xi, Qiaoran; Chen, Zhucheng
  作者单位：Tsinghua University; University of California System; University of California Los Angeles
  摘要：Chromatin remodellers are pivotal in the regulation of nucleosome dynamics in cells, and they are important for chromatin packaging, transcription, replication and DNA repair1. Here we show that the human chromatin remodeller SMARCAD1 exhibits a substrate preference for subnucleosomal particles over the canonical nucleosome. Cryo-electron microscopy structures of SMARCAD1 bound to the nucleosome and hexasome provide mechanistic insights into the substrate selectivity. SMARCAD1 binds to the hex...
• Why amphibious, wet environments hold the key to climate adaptation AI翻译
  作者：Ananya
• Astronomers gave up this comet for dead - but they were wrong AI翻译
  作者：[Anonymous]
• Kupffer cell programming by maternal obesity triggers fatty liver disease AI翻译
  作者：Huang, Hao; Balzer, Nora R.; Seep, Lea; Splichalova, Iva; Blank-Stein, Nelli; Viola, Maria Francesca; Franco Taveras, Eliana; Acil, Kerim; Fink, Diana; Petrovic, Franzisca; Makdissi, Nikola; Bayar, Seyhmus; Mauel, Katharina; Radwaniak, Carolin; Zurkovic, Jelena; Kayvanjoo, Amir H.; Wunderling, Klaus; Jessen, Malin; Yaghmour, Mohamed H.; Kenner, Lukas; Ulas, Thomas; Grein, Stephan; Schultze, Joachim L.; Scott, Charlotte L.; Guilliams, Martin; Liu, Zhaoyuan; Ginhoux, Florent; Beyer, Marc D.; Thiele, Christoph; Meissner, Felix; Hasenauer, Jan; Wachten, Dagmar; Mass, Elvira
  作者单位：University of Bonn; University of Bonn; University of Bonn; University of Bonn; University of Bonn; Medical University of Vienna; Medical University of Vienna; University of Veterinary Medicine Vienna; Umea University; Medical University of Vienna; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Bonn; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Bonn; Ghent University; Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; Flanders Institute for Biotechnology (VIB); Chinese Academy of Sciences; Shanghai Jiao Tong University; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Bonn
  摘要：Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1, 2-3. Throughout development and adulthood, KCs perform distinct core functions that are essential for liver and organismal homeostasis, including supporting fetal erythropoiesis, postnatal erythrocyte recycling and liver metabolism4. Ho...
• Flat-panel laser displays through large-scale photonic integrated circuits AI翻译
  作者：Shi, Zhujun; Cheng, Risheng; Wei, Guohua; Hickman, Steven A.; Shin, Min Chul; Topalian, Peter; Wang, Lei; Coso, Dusan; Wang, Youmin; Wang, Qingjun; Le, Brian; Lee, Lizzy; Lopez, Daniel; Wu, Yuhang; Braxton, Sean; Koshelev, Alexander; Parsons, Maxwell F.; Agarwal, Rahul; Silverstein, Barry; Wang, Yun; Calafiore, Giuseppe
  摘要：Laser-based displays are highly sought after for their superior brightness and colour performance1, especially in advanced applications such as augmented reality (AR)2. However, their broader use has been hindered by bulky projector designs and complex optical module assemblies3. Here we introduce a laser display architecture enabled by large-scale visible photonic integrated circuits (PICs)4, 5, 6-7 to address these challenges. Unlike previous projector-style laser displays, this architecture...
• What counts as plagiarism? AI-generated papers pose new risks AI翻译
  作者：Ananya
• Electrochemical loading enhances deuterium fusion rates in a metal target AI翻译
  作者：Chen, Kuo-Yi; Maiwald, Jannis; Schauer, Phil A.; Issinski, Sergey; Garcia, Fatima H.; Oldford, Ryan; Egoriti, Luca; Higashino, Shota; Vakili, Aref E.; Wen, Yunzhou; Koh, Joseph Z. X.; Schenkel, Thomas; Stolar, Monika; Brown, Amanda K.; Berlinguette, Curtis P.
  作者单位：University of British Columbia; University of British Columbia; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of British Columbia; University of British Columbia; Canadian Institute for Advanced Research (CIFAR)
  摘要：Nuclear fusion research for energy applications aims to create conditions that release more energy than required to initiate the fusion process1. To generate meaningful amounts of energy, fuels such as deuterium need to be spatially confined to increase the collision probability of particles2, 3-4. We therefore set out to investigate whether electrochemically loading a metal lattice with deuterium fuel could increase the probability of nuclear fusion events. Here we report a benchtop fusion re...
• Weight loss alters adipose tissue beyond just reducing fat AI翻译
  作者：Rosen, Evan D.; Emont, Margo P.
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; University of Chicago
• Super-efficient teamwork is possible - if you're an ant AI翻译
  作者：[Anonymous]
• Diffusing protein binders to intrinsically disordered proteins AI翻译
  作者：Liu, Caixuan; Wu, Kejia; Choi, Hojun; Han, Hannah L.; Zhang, Xueli; Watson, Joseph L.; Ahn, Green; Zhang, Jason Z.; Shijo, Sara; Good, Lydia L.; Fischer, Charlotte M.; Bera, Asim K.; Kang, Alex; Brackenbrough, Evans; Coventry, Brian; Hick, Derrick R.; Qamar, Seema; Li, Xinting; Decarreau, Justin; Gerben, Stacey R.; Yang, Wei; Goreshnik, Inna; Vafeados, Dionne; Wang, Xinru; Lamb, Mila; Murray, Analisa; Kenny, Sebastian; Bauer, Magnus S.; Hoofnagle, Andrew N.; Zhu, Ping; Knowles, Tuomas P. J.; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Washington; University of Washington Seattle; University of Cambridge; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); University of Cambridge; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
  摘要：Proteins that bind to intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could be useful for therapeutic and diagnostic applications1, 2, 3-4. However, a general methodology for targeting IDPs or IDRs has yet to be developed. Here we show that starting only from the target sequence of the input, and freely sampling both target and binding protein conformations, RFdiffusion5 can generate binders to IDPs and IDRs in a wide rang...