-
作者：Dinezio, Pedro N.; Shanahan, Timothy M.; Sun, Tianyi; Sun, Chijun; Wu, Xian; Lawman, Allison; Lea, David; Kageyama, Masa; Merkel, Ute; Prange, Matthias; Otto-Bliesner, Bette; Zhang, Xu
作者单位：University of Colorado System; University of Colorado Boulder; University of Texas System; University of Texas Austin; Environmental Defense Fund; University of California System; University of California Davis; University of Texas System; University of Texas Dallas; Colorado College; University of California System; University of California Santa Barbara; Universite Paris Saclay; University of Bremen; National Center Atmospheric Research (NCAR) - USA; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey
摘要：Projections of tropical rainfall under global warming remain highly uncertain1,2, largely because of an unclear climate response to a potential weakening of the Atlantic meridional overturning circulation (AMOC)3. Although an AMOC slowdown can substantially alter tropical rainfall patterns4, 5, 6, 7-8, the physical mechanisms linking high-latitude changes to tropical hydroclimate are poorly understood11. Here we demonstrate that an AMOC slowdown drives widespread shifts in tropical rainfall th...
-
作者：Ooi, Leon Qi Rong; Orban, Csaba; Zhang, Shaoshi; Nichols, Thomas E.; Tan, Trevor Wei Kiat; Kong, Ru; Marek, Scott; Dosenbach, Nico U. F.; Laumann, Timothy O.; Gordon, Evan M.; Yap, Kwong Hsia; Ji, Fang; Chong, Joanna Su Xian; Chen, Christopher; An, Lijun; Franzmeier, Nicolai; Roemer-Cassiano, Sebastian N.; Hu, Qingyu; Ren, Jianxun; Liu, Hesheng; Chopra, Sidhant; Cocuzza, Carrisa V.; Baker, Justin T.; Zhou, Juan Helen; Bzdok, Danilo; Eickhoff, Simon B.; Holmes, Avram J.; Yeo, B. T. Thomas
作者单位：National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; University of Oxford; University of Oxford; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); National University of Singapore; National University of Singapore; Lund University; SciLifeLab; University of Munich; University of Munich; University of Gothenburg; University of Munich; Changping Laboratory; Peking University; Orygen, The National Centre of Excellence in Youth Mental Health; Orygen, The National Centre of Excellence in Youth Mental Health; University of Melbourne; Yale University; Rutgers University System; Rutgers University New Brunswick; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; McLean Hospital; McGill University; Mila Quebec Artificial Intelligence Institute; Helmholtz Association; Research Center Julich; Heinrich Heine University Dusseldorf; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：A pervasive dilemma in brain-wide association studies1 (BWAS) is whether to prioritize functional magnetic resonance imaging (fMRI) scan time or sample size. We derive a theoretical model showing that individual-level phenotypic prediction accuracy increases with sample size and total scan duration (sample size x scan time per participant). The model explains empirical prediction accuracies well across 76 phenotypes from nine resting-fMRI and task-fMRI datasets (R2 = 0.89), spanning diverse sc...
-
作者：Kubiszewski, Ida; Costanza, Robert; Fulton, Elizabeth A.; King, Matt A.; Leane, Elizabeth; Stoeckl, Natalie
作者单位：University of London; University College London; Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of Tasmania; University of Tasmania; University of Tasmania; University of Tasmania
-
作者：Falasconi, Antonio; Kanodia, Harsh; Arber, Silvia
作者单位：University of Basel; Friedrich Miescher Institute for Biomedical Research
摘要：The basal ganglia are fundamental to motor control and their dysfunction is linked to motor deficits1, 2, 3, 4, 5, 6, 7-8. Influential investigations on the primate oculomotor system posited that movement generally depends on transient pauses of tonically firing inhibitory basal ganglia output neurons releasing brainstem motor centres9,10. However, prominent increases in basal ganglia output neuron firing observed during other motor tasks cast doubts on the proposed mechanisms of movement regu...
-
作者：Ahart, Jenna
-
作者：Nugent, Anya; Nugent, Peter
作者单位：Harvard University; Smithsonian Institution; Smithsonian Astrophysical Observatory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
-
作者：Calhoon, Dylan; Sang, Lingjie; Ji, Fubo; Bezwada, Divya; Hsu, Sheng-Chieh; Cai, Feng; Kim, Nathaniel; Basu, Amrita; Wu, Renfei; Pimentel, Anastasia; Brooks, Bailey; La, Konnor; Paulina Serrano, Ana; Cassidy, Daniel L.; Cai, Ling; Toffessi-Tcheuyap, Vanina; Moussa, Maryam E.; Uritboonthai, Winnie; Hoang, Linh Truc; Kolli, Meghana; Jackson, Brooklyn; Margulis, Vitaly; Siuzdak, Gary; Brugarolas, James; Corbin, Ian; Pratt, Derek A.; Weiss, Ryan J.; DeBerardinis, Ralph J.; Birsoy, Kivanc; Garcia-Bermudez, Javier
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University System of Georgia; University of Georgia; Rockefeller University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Ottawa; Scripps Research Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University System of Georgia; University of Georgia; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Lipids are essential components of cancer cells due to their structural and signalling roles1. To meet metabolic demands, many cancers take up extracellular lipids2, 3, 4-5; however, how these lipids contribute to cancer growth and progression remains poorly understood. Here, using functional genetic screens, we identify uptake of lipoproteins-the primary mechanism for lipid transport in circulation-as a key determinant of ferroptosis sensitivity in cancer. Lipoprotein supplementation robustly...
-
作者：Feng, Rui; Fan, Kejia; Zhao, Yongjun; Qi, Zhuangzhou
作者单位：Hangzhou Normal University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
-
作者：Gibney, Elizabeth
-
作者：Taylor, Christopher H.; Watson, David James George; Skelhorn, John; Bell, Danny; Burdett, Simon; Codyre, Aoife; Cooley, Kathryn; Davies, James R.; Dawson, Joshua Joseph; D'Cruz, Tahire; Gandhi, Samir Raj; Jackson, Hannah J.; Lowe, Rebecca; Ogilvie, Elizabeth; Pond, Alexandra Lei; Rees, Hallie; Richardson, Joseph; Sains, Joshua; Short, Francis; Brignell, Christopher; Davidson, Gabrielle L.; Rowland, Hannah M.; East, Mark; Goodridge, Ruth; Gilbert, Francis; Reader, Tom
作者单位：University of Nottingham; Newcastle University - UK; University of Bristol; University of Nottingham; University of Cambridge; University of East Anglia; Max Planck Society; University of Liverpool; University of Nottingham
摘要：In a classic example of adaptation, harmless Batesian mimics gain protection from predators through resemblance to one or more unpalatable models1,2. Mimics vary greatly in accuracy, and explaining the persistence of inaccurate mimics is an ongoing challenge for evolutionary biologists3,4. Empirical testing of existing hypotheses is constrained by the difficulty of assessing the fitness of phenotypes absent among extant species, leaving large parts of the adaptive landscape unexplored5-a probl...
