作者：Nuckolls, Kevin P.; Scheer, Michael G.; Wong, Dillon; Oh, Myungchul; Lee, Ryan L.; Herzog-Arbeitman, Jonah; Watanabe, Kenji; Taniguchi, Takashi; Lian, Biao; Yazdani, Ali
作者单位：Princeton University; Princeton University; National Institute for Materials Science; National Institute for Materials Science; Massachusetts Institute of Technology (MIT); Pohang University of Science & Technology (POSTECH)
摘要：Hofstadter's butterfly, the predicted energy spectrum for non-interacting electrons confined to a two-dimensional lattice in a magnetic field, is one of the most remarkable fractal structures in nature1. At rational ratios of magnetic flux quanta per lattice unit cell, this spectrum shows self-similar distributions of energy levels that reflect its recursive construction. For most materials, Hofstadter's butterfly is predicted under experimental conditions that are unachievable using laborator...
作者：Yeo, Megan J. R.; Zhang, Olivia; Xie, Xiaowen; Nam, Eunju; Payne, N. Connor; Gosavi, Pallavi M.; Kwok, Hui Si; Iram, Irtiza; Lee, Ceejay; Li, Jiaming; Chen, Nicholas J.; Nguyen, Khanh; Jiang, Hanjie; Wang, Zhipeng A.; Lee, Kwangwoon; Mao, Haibin; Harry, Stefan A.; Barakat, Idris A.; Takahashi, Mariko; Waterbury, Amanda L.; Barone, Marco; Mattevi, Andrea; Carr, Steven A.; Udeshi, Namrata D.; Bar-Peled, Liron; Cole, Philip A.; Mazitschek, Ralph; Liau, Brian B.; Zheng, Ning
作者单位：Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Pavia; Harvard University; Harvard Medical School; University of Miami; University of Miami
摘要：UM171 is a potent agonist of ex vivo human haematopoietic stem cell self-renewal1. By co-opting KBTBD4, a substrate receptor of the CUL3-RING E3 ubiquitin ligase (CRL3) complex, UM171 promotes the degradation of the LSD1-CoREST corepressor complex, thereby limiting haematopoietic stem cell attrition2,3. However, the direct target and mechanism of action of UM171 remain unclear. Here we show that UM171 acts as a molecular glue to induce high-affinity interactions between KBTBD4 and HDAC1/2 to p...
作者：Shan, Kaiyue; Lin, Yanluan; Chu, Pao-Shin; Yu, Xiping; Song, Fengfei
作者：Saag, Lehti; Metspalu, Mait
作者单位：University of Tartu; Estonian Biocentre
