2025

最新文章

• Arctic researchers need to find ways to keep working together AI翻译
  作者：Christensen, Torben R.
  作者单位：Aarhus University; University of Oulu
• Radical approach to shrink particle colliders gains momentum AI翻译
  作者：Gibney, Elizabeth
• Print, melt, repeat: 3D-printing formula yields sturdy objects time after time AI翻译
  作者：[Anonymous]
• Programs, origins and immunomodulatory functions of myeloid cells in glioma AI翻译
  作者：Miller, Tyler E.; El Farran, Chadi A.; Couturier, Charles P.; Chen, Zeyu; D'Antonio, Joshua P.; Verga, Julia; Villanueva, Martin A.; Castro, L. Nicolas Gonzalez; Tong, Yuzhou Evelyn; Saadi, Tariq Al; Chiocca, Andrew N.; Zhang, Yuanyuan; Fischer, David S.; Heiland, Dieter Henrik; Guerriero, Jennifer L.; Petrecca, Kevin; Suva, Mario L.; Shalek, Alex K.; Bernstein, Bradley E.
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Ragon Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; McGill University; University of Freiburg; Northwestern University; Feinberg School of Medicine; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; McGill University
  摘要：Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the immunomodulatory phenotypes of which remain poorly defined1. Here we systematically investigate these phenotypes by integrating single-cell RNA sequencing, chromatin accessibility, spatial transcriptomics and glioma organoid explant systems. We discovered four immunomodulatory expression programs: microglial inflammatory and scavenger immunosuppressive programs, which ar...
• Characterization of single neurons reprogrammed by pancreatic cancer AI翻译
  作者：Thiel, Vera; Renders, Simon; Panten, Jasper; Dross, Nicolas; Bauer, Katharina; Azorin, Daniel; Henriques, Vanessa; Vogel, Vanessa; Klein, Corinna; Leppae, Aino-Maija; Ortega, Isabel Barriuso; Schwickert, Jonas; Ourailidis, Iordanis; Mochayedi, Julian; Mallm, Jan-Philipp; Mueller-Tidow, Carsten; Monyer, Hannah; Neoptolemos, John; Hackert, Thilo; Stegle, Oliver; Odom, Duncan T.; Offringa, Rienk; Stenzinger, Albrecht; Winkler, Frank; Sprick, Martin; Trumpp, Andreas
  作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Nikon Corporation; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; National Center for Tumor Diseases
  摘要：The peripheral nervous system (PNS) orchestrates organ function in health and disease. Most cancers, including pancreatic ductal adenocarcinoma (PDAC), are infiltrated by PNS neurons, and this contributes to the complex tumour microenvironment (TME)1,2. However, neuronal cell bodies reside in various PNS ganglia, far from the tumour mass. Thus, cancer-innervating or healthy-organ-innervating neurons are lacking in current tissue-sequencing datasets. To molecularly characterize pancreas- and PD...
• Five key climate and space projects on Trump's chopping block AI翻译
  作者：Witze, Alexandra; Garisto, Dan; Tollefson, Jeff
• Latitudinal scaling of aggregation with abundance and coexistence in forests AI翻译
  作者：Wiegand, Thorsten; Wang, Xugao; Fischer, Samuel M.; Kraft, Nathan J. B.; Bourg, Norman A.; Brockelman, Warren Y.; Cao, Guanghong; Cao, Min; Chanthorn, Wirong; Chu, Chengjin; Davies, Stuart; Ediriweera, Sisira; Gunatilleke, C. V. Savitri; Gunatilleke, I. A. U. Nimal; Hao, Zhanqing; Howe, Robert; Jiang, Mingxi; Jin, Guangze; Kress, W. John; Li, Buhang; Lian, Juyu; Lin, Luxiang; Liu, Feng; Ma, Keping; Mcshea, William; Mi, Xiangcheng; Myers, Jonathan A.; Nathalang, Anuttara; Orwig, David A.; Shen, Guochun; Su, Sheng-Hsin; Sun, I-Fang; Wang, Xihua; Wolf, Amy; Yan, Enrong; Ye, Wanhui; Zhu, Yan; Huth, Andreas
  作者单位：Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; University of California System; University of California Los Angeles; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; National Science & Technology Development Agency - Thailand; Chinese Academy of Sciences; Xishuangbanna Tropical Botanical Garden, CAS; Kasetsart University; Sun Yat Sen University; Smithsonian Institution; Smithsonian Tropical Research Institute; Uva Wellassa University; University of Peradeniya; Northwestern Polytechnical University; University of Wisconsin System; Chinese Academy of Sciences; Wuhan Botanical Garden, CAS; Northeast Forestry University - China; Smithsonian Institution; Smithsonian National Museum of Natural History; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; Institute of Botany, CAS; Washington University (WUSTL); Harvard University; East China Normal University; National Dong Hwa University; University Osnabruck
  摘要：The search for simple principles that underlie the spatial structure and dynamics of plant communities is a long-standing challenge in ecology1, 2, 3, 4, 5-6. In particular, the relationship between species coexistence and the spatial distribution of plants is challenging to resolve in species-rich communities7, 8-9. Here we present a comprehensive analysis of the spatial patterns of 720 tree species in 21 large forest plots and their consequences for species coexistence. We show that species ...
• Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in macaques AI翻译
  作者：Rosenke, Kyle; Griffin, Amanda; Kaiser, Franziska; Altynova, Ekaterina; Mukesh, Reshma; Bushmaker, Trenton; Flagg, Meaghan; Tipih, Thomas; Goldin, Kerry; Wickenhagen, Arthur; Williamson, Brandi N.; Gallogly, Shane; Leventhal, Shanna S.; Lutterman, Tessa; Okumura, Atsushi; Lewis, Matthew C.; Kanakabandi, Kishore; Martens, Craig; Yinda, Kwe C.; Rao, Deepashri; Smith, Brian J.; Shaia, Carl; Saturday, Greg; Hanley, Patrick; van Doremalen, Neeltje; de Wit, Emmie; Munster, Vincent J.; Feldmann, Heinz
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
  摘要：Since early 2022, highly pathogenic avian influenza (HPAI) H5N1 virus infections have been reported in wild aquatic birds and poultry throughout the USA with spillover into several mammalian species1, 2, 3, 4, 5-6. In March 2024, HPAIV H5N1 clade 2.3.4.4b was first detected in dairy cows in Texas, USA, and continues to circulate on dairy farms in many states7,8. Milk production and quality are diminished in infected dairy cows, with high virus titres in milk raising concerns of exposure to mam...
• Mystery of medieval manuscripts revealed by ancient DNA AI翻译
  作者：[Anonymous]
• TIR1-produced cAMP as a second messenger in transcriptional auxin signalling AI翻译
  作者：Chen, Huihuang; Qi, Linlin; Zou, Minxia; Lu, Mengting; Kwiatkowski, Mateusz; Pei, Yuanrong; Jaworski, Krzysztof; Friml, Jiri
  作者单位：Institute of Science & Technology - Austria; Shenzhen University of Advanced Technology; Shenzhen University of Advanced Technology; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Nicolaus Copernicus University
  摘要：The phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin ligase complex; after auxin perception, they associate with Aux/IAA transcriptional repressors and ubiquitinate them for degradation, thus enabling the activation of auxin response factor (ARF) transcription factors1, 2-3. Here we revise this paradigm by ...