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作者：Fountas, Costas
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作者：Goncalves, Mauer; Ribeiro Junior, Howard Lopes
作者单位：University Agostinho Neto; Universidade Federal do Ceara
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作者：Capek, Matthew; Arenas, Oscar M.; Alpert, Michael H.; Zaharieva, Emanuela E.; Mendez-Gonzalez, Ivan D.; Simoes, Jose Miguel; Gil, Hamin; Acosta, Aldair; Su, Yuqing; Para, Alessia; Gallio, Marco
作者单位：Northwestern University; University of California System; University of California Berkeley; Reed College - Portland
摘要：The preference for a particular thermal range is a key determinant of the distribution of animal species. However, we know little on how temperature preference behaviour evolves during the colonization of new environments. Here we show that at least two distinct neurobiological mechanisms drive the evolution of temperature preference in flies of the genus Drosophila. Fly species from mild climates (D. melanogaster and D. persimilis) avoid both innocuous and noxious heat, and we show that the t...
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作者：Garber, Ken
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作者：Merkenschlager, Julia; Pyo, Andrew G. T.; Silva Santos, Gabriela S.; Schaefer-Babajew, Dennis; Cipolla, Melissa; Hartweger, Harald; Gitlin, Alexander D.; Wingreen, Ned S.; Nussenzweig, Michel C.
作者单位：Rockefeller University; Harvard University; Harvard Medical School; Princeton University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Princeton University; Princeton University; Howard Hughes Medical Institute; Rockefeller University
摘要：Germinal centres are specialized microenvironments where B cells undergo affinity maturation. B cells expressing antibodies whose affinity is improved by somatic hypermutation are selected for expansion by limiting numbers of T follicular helper cells. Cell division is accompanied by mutation of the immunoglobulin genes, at what is believed to be a fixed rate of around 1 x 10-3 per base pair per cell division1. As mutagenesis is random, the probability of acquiring deleterious mutations outwei...
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作者：Miguez-Cabello, Federico; Wang, Xin-tong; Yan, Yuhao; Brake, Niklas; Alexander, Ryan P. D.; Perozzo, Amanda M.; Khadra, Anmar; Bowie, Derek
作者单位：McGill University; McGill University; McGill University; McGill University
摘要：Fast excitatory neurotransmission in the mammalian brain is mediated by cation-selective AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors (AMPARs)1. AMPARs are critical for the learning and memory mechanisms of Hebbian plasticity2 and glutamatergic synapse homeostasis3, with recent work establishing that AMPAR missense mutations can cause autism and intellectual disability4, 5, 6-7. AMPARs have been grouped into two functionally distinct tetrameric assemblies based on ...
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作者：Schoofs, Hans; Daubel, Nina; Schnabellehner, Sarah; Gronloh, Max L. B.; Martinez, Sebastian Palacios; Halme, Aleksi; Marks, Amanda M.; Jeansson, Marie; Barcos, Sara; Brakebusch, Cord; Benedito, Rui; Engelhardt, Britta; Vestweber, Dietmar; Gaengel, Konstantin; Linsenmeier, Fabian; Schurmann, Sebastian; Saharinen, Pipsa; van Buul, Jaap D.; Friedrich, Oliver; Smith, Richard S.; Majda, Mateusz; Makinen, Taija
作者单位：Uppsala University; University of Amsterdam; University of Amsterdam; University of Helsinki; University of Bern; Theodor Kocher Institute; University of Copenhagen; Centro Nacional de Investigaciones Cardiovasculares (CNIC); Max Planck Society; University of Erlangen Nuremberg; Wihuri Research Institute; University of Amsterdam; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of Lausanne
摘要：Lymphatic capillaries continuously take up interstitial fluid and adapt to resulting changes in vessel calibre1, 2-3. The mechanisms by which the permeable monolayer of loosely connected lymphatic endothelial cells (LECs)4 maintains mechanical stability remain elusive. Here we identify dynamic cytoskeletal regulation of LEC shape, induced by isotropic stretch, as crucial for the integrity and function of dermal lymphatic capillaries. We found that the oak leaf-shaped LECs showed a spectrum of ...
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作者：Lubell, Michael S.
作者单位：City University of New York (CUNY) System; City College of New York (CUNY)
摘要：There's no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.
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作者：[Anonymous]
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作者：Shen, Yinan; Bai, Xueli; Zhang, Qi; Liang, Xingmei; Jin, Xinyan; Zhao, Zeda; Song, Wei; Tan, Qian; Zhao, Ronghua; Jia, William; Gu, Shanzhi; Shi, Guoming; Zheng, Ziwei; Wei, Guyue; Wang, Youlei; Fang, Tian; Li, Yuwei; Wang, Zijun; Yang, Zifan; Guo, Sida; Lin, Danni; Wei, Fang; Wang, Lei; Sun, Xiaoli; Qin, Aijun; Xie, Longshen; Qiu, Yeting; Bao, Wenqing; Rahimian, Shah; Singh, Manu; Murad, Yanal; Shang, Jianying; Chu, Min; Huang, Maoliang; Ding, Jun; Chen, Wei; Ye, Yufu; Chen, Yiwen; Li, Xiang; Liang, Tingbo
