2025

最新文章

• Tattoo-making tools used by ancient Maya revealed AI翻译
  作者：[Anonymous]
• Stress dynamically modulates neuronal autophagy to gate depression onset AI翻译
  作者：Yang, Liang; Guo, Chen; Zheng, Zhiwei; Dong, Yiyan; Xie, Qifeng; Lv, Zijian; Li, Min; Lu, Yangyang; Guo, Xiaonan; Deng, Rongshan; Liu, Yiqin; Feng, Yirong; Mu, Ruiqi; Zhang, Xuliang; Ma, Huan; Chen, Zhong; Zhang, Zhijun; Dong, Zhaoqi; Yang, Wei; Zhang, Xiangnan; Cui, Yihui
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang Chinese Medical University; Southeast University - China; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Capital Medical University
  摘要：Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders1. As a key modulator of brain homeostasis2, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute stress activates, whereas chronic stress suppresses, autophagy mainly in the lateral habenula (LHb). Systemic administration of distinct antidepressant drugs similarly restores autophagy function in the LHb, suggesting LHb autophagy as a common...
• The global human impact on biodiversity AI翻译
  作者：Keck, Francois; Peller, Tianna; Alther, Roman; Barouillet, Cecilia; Blackman, Rosetta; Capo, Eric; Chonova, Teofana; Couton, Marjorie; Fehlinger, Lena; Kirschner, Dominik; Knusel, Mara; Muneret, Lucile; Oester, Rebecca; Tapolczai, Kalman; Zhang, Heng; Altermatt, Florian
  作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Umea University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Universitat de Vic - Universitat Central de Catalunya (UVic-UCC); Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; AgroParisTech; INRAE; Universite Paris Saclay; Institut Agro; AgroSup Dijon; INRAE; Universite Bourgogne Europe; HUN-REN; HUN-REN Balaton Limnological Research Institute; HUN-REN; HUN-REN Balaton Limnological Research Institute
  摘要：Human activities drive a wide range of environmental pressures, including habitat change, pollution and climate change, resulting in unprecedented effects on biodiversity1,2. However, despite decades of research, generalizations on the dimensions and extent of human impacts on biodiversity remain ambiguous. Mixed views persist on the trajectory of biodiversity at the local scale3 and even more so on the biotic homogenization of biodiversity across space4,5. We compiled 2,133 publications cover...
• Climate risk for younger generations is set to soar AI翻译
  作者：Gualdi, Rosanna; Muttarak, Raya
  作者单位：University of Bologna
• Time for adults to finally act like adults on climate change AI翻译
  作者：[Anonymous]
• Melt focusing along lithosphere-asthenosphere boundary below Axial volcano AI翻译
  作者：Kent, G. M.; Arnulf, A. F.; Singh, S. C.; Carton, H.; Harding, A. J.; Saustrup, S.
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite Paris Cite; University of Texas System; University of Texas Austin; Amazon.com; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：Beneath oceanic spreading centres, the lithosphere-asthenosphere boundary (LAB) acts as a permeability barrier that focuses the delivery of melt from deep within the mantle towards the spreading axis1. At intermediate-spreading to fast-spreading ridge crests, the multichannel seismic reflection technique has imaged a nearly flat, 1-2-km-wide axial magma lens (AML)2 that defines the uppermost section of the LAB3, but the nature of the LAB deeper into the crust has been more elusive, with some c...
• Structural dynamics of human fatty acid synthase in the condensing cycle AI翻译
  作者：Choi, Wooyoung; Li, Chengmin; Chen, Yifei; Wang, YongQiang; Cheng, Yifan
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco
  摘要：Long-chain fatty acids are the building blocks of fat in human bodies. In mammals, fatty acid synthase (FASN) contains multiple enzymatic domains to catalyse all chemical reactions needed for de novo fatty acid synthesis1. Although the chemical reactions carried out by these enzymatic domains are well defined, how the dimeric FASN with an open architecture continuously catalyses such reactions to synthesize a complete fatty acid remains elusive. Here, using a strategy of tagging and purifying ...
• Want to supercharge your science? Turn to technicians AI翻译
  作者：Narayanamurti, Venkatesh; Currall, Steven C.
  作者单位：Harvard University; Harvard University; Harvard University; State University System of Florida; University of South Florida
• One of the world's richest lithium deposits began inside a mega-volcano AI翻译
  作者：[Anonymous]
  摘要：Lithium that pooled in a volcanic caldera in the western United States had no way out, thanks to a lack of rivers.
• Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis AI翻译
  作者：Jia, Shidong; Liu, Zhenning; Zhang, Sen; Liu, Pixu; Zhang, Lei; Lee, Sang Hyun; Zhang, Jing; Signoretti, Sabina; Loda, Massimo; Roberts, Thomas M.; Zhao, Jean J.