Science

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• The mechanics of plant morphogenesis AI翻译
  作者：Coen, Enrico; Cosgrove, Daniel J.
  作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
• Single-carbon atom transfer to a,b-unsaturated amides from N-heterocyclic carbenes AI翻译
  作者：Kamitani, Miharu; Nakayasu, Bunta; Fujimoto, Hayato; Yasui, Kosuke; Kodama, Takuya; Tobisu, Mamoru
  作者单位：University of Osaka; University of Osaka
  摘要：Single-carbon atom transfer reactions are lacking in organic synthesis, partly because of the absence of atomic carbon sources under standard solution-phase conditions. We report here that N-heterocyclic carbenes can serve as atomic carbon donors through the loss of a 1,2-diimine moiety. This strategy is applicable to single-carbon atom transfer to a,b-unsaturated amides, which can be converted into homologated g-lactams through the formation of four single bonds to one carbon center in one op...
• Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides AI翻译
  作者：Bridges, Hannah R.; Blaza, James N.; Yin, Zhan; Chung, Injae; Pollak, Michael N.; Hirst, Judy
  作者单位：University of Cambridge; University of York - UK; University of York - UK; Lady Davis Institute; McGill University; McGill University
  摘要：The molecular mode of action of biguanides, including the drug metformin, which is widely used in the treatment of diabetes, is incompletely characterized. Here, we define the inhibitory drug-target interaction(s) of a model biguanide with mammalian respiratory complex I by combining cryo-electron microscopy and enzyme kinetics. We interpret these data to explain the selectivity of biguanide binding to different enzyme states. The primary inhibitory site is in an amphipathic region of the quin...
• ChatGPT is fun, but not an author AI翻译
  作者：Thorp, H. Holden
• A powerful 21st-century medium affords new opportunities for learning and creative thinkingBOOKS et al.INSIGHTS Science in the age of podcasts AI翻译
  作者：Gomez-Marin, Alex
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN)
• Bird flu spread between mink is a 'warning bell' AI翻译
  作者：Kupferschmidt, Kai
• Collective super- and subradiant dynamics between distant optical quantum emitters AI翻译
  作者：Tiranov, Alexey; Angelopoulou, Vasiliki; Schrinski, Bjorn; van Diepen, Cornelis Jacobus; Sandberg, Oliver August Dall Alba; Wang, Ying; Midolo, Leonardo; Scholz, Sven; Wieck, Andreas Dirk; Ludwig, Arne; Sorensen, Anders Sondberg; Lodahl, Peter
  作者单位：University of Copenhagen; Ruhr University Bochum
  摘要：Photon emission is the hallmark of light-matter interaction and the foundation of photonic quantum science, enabling advanced sources for quantum communication and computing. Although single-emitter radiation can be tailored by the photonic environment, the introduction of multiple emitters extends this picture. A fundamental challenge, however, is that the radiative dipole-dipole coupling rapidly decays with spatial separation, typically within a fraction of the optical wavelength. We realize...
• AI helps find missed meteorites AI翻译
  作者：Brainard, Jeffrey
• Comment on Interspecific competition limits bird species' ranges in tropical mountains AI翻译
  作者：Xing, Dingliang; Zhang, Jian; He, Fangliang
  作者单位：East China Normal University; East China Normal University; University of Alberta
• Human geneticists apologize AI翻译
  作者：Brainard, Jeffrey