作者：Krypotou, Emilia; Townsend, Guy E.; Gao, Xiaohui; Tachiyama, Shoichi; Liu, Jun; Pokorzynski, Nick D.; Goodman, Andrew L.; Groisman, Eduardo A.
作者单位：Yale University; Yale University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health
摘要：Therapeutic manipulation of the gut microbiota holds great potential for human health. The mechanisms bacteria use to colonize the gut therefore present valuable targets for clinical intervention. We now report that bacteria use phase separation to enhance fitness in the mammalian gut. We establish that the intrinsically disordered region (IDR) of the broadly and highly conserved transcription termination factor Rho is necessary and sufficient for phase separation in vivo and in vitro in the h...
作者：Lin, Zeming; Akin, Halil; Rao, Roshan; Hie, Brian; Zhu, Zhongkai; Lu, Wenting; Smetanin, Nikita; Verkuil, Robert; Kabeli, Ori; Shmueli, Yaniv; Costa, Allan dos Santos; Fazel-Zarandi, Maryam; Sercu, Tom; Candido, Salvatore; Rives, Alexander
作者单位：New York University; Stanford University; Massachusetts Institute of Technology (MIT)
摘要：Recent advances in machine learning have leveraged evolutionary information in multiple sequence alignments to predict protein structure. We demonstrate direct inference of full atomic-level protein structure from primary sequence using a large language model. As language models of protein sequences are scaled up to 15 billion parameters, an atomic-resolution picture of protein structure emerges in the learned representations. This results in an order-of-magnitude acceleration of high-resoluti...
作者：Hawk, Larry W.
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY
作者：Brainard, Jeffrey
摘要：NEUTRON RESEARCH | This week, regulators gave the go-ahead to restart a small U.S. research reactor, 2 years after an accident shut it down and cut almost by half the nation's capacity to use neutrons to study materials. The February 2021 incident at the 20-megawatt, neutrongenerating reactor at the National Institute of Standards and Technology (NIST) in Gaithersburg, Maryland, occurred when one of its 30 rodlike, uranium-filled fuel pins popped out of place, overheated, and partially melted....
作者：O'Brien, Niamh; Mizielinska, Sarah
作者单位：University of London; King's College London
