作者：Ding, Haoming; Li, Youbing; Li, Mian; Chen, Ke; Liang, Kun; Chen, Guoxin; Lu, Jun; Palisaitis, Justinas; Persson, Per O. A.; Eklund, Per; Hultman, Lars; Du, Shiyu; Chai, Zhifang; Gogotsi, Yury; Huang, Qing
作者单位：Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Linkoping University; Drexel University; Advanced Energy Science & Technology Guangdong Laboratory
摘要：Intercalated layered materials offer distinctive properties and serve as precursors for important two-dimensional (2D) materials. However, intercalation of non-van der Waals structures, which can expand the family of 2D materials, is difficult. We report a structural editing protocol for layered carbides (MAX phases) and their 2D derivatives (MXenes). Gap-opening and species-intercalating stages were respectively mediated by chemical scissors and intercalants, which created a large family of M...
作者：Mace, Peter D.; Day, Catherine L.
作者单位：University of Otago
作者：Baughn, Michael W.; Melamed, Ze'ev; Lopez-Erauskin, Jone; Beccari, Melinda S.; Ling, Karen; Zuberi, Aamir; Presa, Maximilliano; Gonzalo-Gil, Elena; Maimon, Roy; Vazquez-Sanchez, Sonia; Chaturvedi, Som; Bravo-Hernandez, Mariana; Taupin, Vanessa; Moore, Stephen; Artates, Jonathan W.; Acks, Eitan; Ndayambaje, I. Sandra; Quadros, Ana R. Agra de Almeida; Jafar-Nejad, Paayman; Rigo, Frank; Bennett, C. Frank; Lutz, Cathleen; Lagier-Tourenne, Clotilde; Cleveland, Don W.
作者单位：University of California System; University of California San Diego; Ludwig Institute for Cancer Research; University of California System; University of California San Diego; Hebrew University of Jerusalem; Ionis Pharmaceuticals, Inc.; Jackson Laboratory; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 mislocalization results in cryptic splicing and polyadenylation of pre-messenger RNAs (pre-mRNAs) encoding stathmin-2 (also known as SCG10), a protein that is required for axonal regeneration. We found that TDP-43 binding to a GU-rich region sterically blocked recognition of the cryptic 3 ' splice site in STMN2 pre-mRNA. Ta...
