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作者：Maury, Eduardo A.; Walsh, Christopher A.; Kahle, Kristopher T.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Surgical innovation is helping to identify roles for somatic mutations in brain disorders Somatic variants are genomic alterations present in some cells of the body but not in others. In contrast to inherited germline variants, somatic variants are typically acquired during postzygotic cell divisions or from environmental factors. Somatic variants in a given tissue can also be highly dynamic, such as in the brain, where the number of clonal variants can change during aging and disease (1). Neu...
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作者：Thorp, H. Holden
摘要：Last week, Science reflected on major achievements in science in 2023, from weight loss drugs and a malaria vaccine to exascale computing and advances in artificial intelligence. These are all impressive developments and provide yet more testimony to the power of science to continually expand the quality of our lives while deepening our understanding of the world. Even so, it's hard to end the year without some worries about 2024. Wars in Ukraine and Gaza will grind on in the new year, and the...
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作者：Langin, Katie
摘要：Though applauded by many, measure would strain lab budgets if adopted
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作者：Lau, Sally C. Y.; Wilson, Nerida G.; Golledge, Nicholas R.; Naish, Tim R.; Watts, Phillip C.; Silva, Catarina N. S.; Cooke, Ira R.; Allcock, A. Louise; Mark, Felix C.; Linse, Katrin; Strugnell, Jan M.
作者单位：James Cook University; James Cook University; James Cook University; Western Australian Museum; University of Western Australia; Western Australian Museum; Victoria University Wellington; University of Jyvaskyla; Universidade de Coimbra; James Cook University; Ollscoil na Gaillimhe-University of Galway; Ollscoil na Gaillimhe-University of Galway; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey
摘要：The marine-based West Antarctic Ice Sheet (WAIS) is considered vulnerable to irreversible collapse under future climate trajectories, and its tipping point may lie within the mitigated warming scenarios of 1.5 degrees to 2 degrees C of the United Nations Paris Agreement. Knowledge of ice loss during similarly warm past climates could resolve this uncertainty, including the Last Interglacial when global sea levels were 5 to 10 meters higher than today and global average temperatures were 0.5 de...
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作者：Yu, Shiqi; Xiong, Zhuang; Zhou, Haitao; Zhang, Qian; Wang, Zhenhan; Ma, Fei; Qu, Zihan; Zhao, Yang; Chu, Xinbo; Zhang, Xingwang; You, Jingbi
作者单位：Chinese Academy of Sciences; Institute of Semiconductors, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The power conversion efficiency (PCE) of inverted perovskite solar cells (PSCs) is still lagging behind that of conventional PSCs, in part because of inefficient carrier transport and poor morphology of hole transport layers (HTLs). We optimized self-assembly of [4-(3,6-dimethyl-9H-carbazol-9-yl)butyl]phosphonic acid (Me-4PACz) onto nickel oxide (NiOx) nanoparticles as an HTL through treatment with hydrogen peroxide, which created a more uniform dispersion of nanoparticles with high conductivi...
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作者：Zhao, S. Y. Frank; Cui, Xiaomeng; Volkov, Pavel A.; Yoo, Hyobin; Lee, Sangmin; Gardener, Jules A.; Akey, Austin J.; Engelke, Rebecca; Ronen, Yuval; Zhong, Ruidan; Gu, Genda; Plugge, Stephan; Tummuru, Tarun; Kim, Miyoung; Franz, Marcel; Pixley, Jedediah H.; Poccia, Nicola; Kim, Philip
作者单位：Harvard University; Rutgers University System; Rutgers University New Brunswick; University of Connecticut; Sogang University; Seoul National University (SNU); Harvard University; United States Department of Energy (DOE); Brookhaven National Laboratory; University of British Columbia; University of British Columbia; Shanghai Jiao Tong University; Shanghai Jiao Tong University
摘要：Twisted interfaces between stacked van der Waals (vdW) cuprate crystals present a platform for engineering superconducting order parameters by adjusting stacking angles. Using a cryogenic assembly technique, we construct twisted vdW Josephson junctions (JJs) at atomically sharp interfaces between Bi2Sr2CaCu2O8+x crystals, with quality approaching the limit set by intrinsic JJs. Near 45 degrees twist angle, we observe fractional Shapiro steps and Fraunhofer patterns, consistent with the existen...
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作者：Coleman, Rosalind A.
作者单位：University of North Carolina; University of North Carolina Chapel Hill
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作者：Couzin-Frankel, Jennifer
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作者：Li, Lijia; Lai, Fangnong; Hu, Xiaoyu; Liu, Bofeng; Lu, Xukun; Lin, Zili; Liu, Ling; Xiang, Yunlong; Frum, Tristan; Halbisen, Michael A.; Chen, Fengling; Fan, Qiang; Ralston, Amy; Xie, Wei
作者单位：Tsinghua University; Tsinghua University; Beijing University of Agriculture; Beijing University of Agriculture; Chongqing Medical University; Michigan State University; University of Michigan System; University of Michigan
摘要：Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in pluripotency regulation. However, the master TF-governed pluripotency regulatory circuitry was largely inferred from cultured cells. In this work, we investigated SOX2 binding from embryonic day 3.5 (E3.5) to E7.5 in the mouse. In E3.5 inner cell mass (ICM), SOX2 regulates the ICM-trophectoderm program but is dispensable for opening global enhancers. Instead, SOX2 occupies preaccessible enhancers in part opened b...
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作者：Mervis, Jeffrey
