Science

最新文章

• Hydrodynamic moiré superlattice AI翻译
  作者：Xu, Guoqiang; Zhou, Xue; Chen, Weijin; Hu, Guangwei; Yan, Zhiyuan; Li, Zhipeng; Yang, Shuihua; Qiu, Cheng-Wei
  作者单位：National University of Singapore; Chongqing Technology & Business University; Nanyang Technological University
  摘要：The structural periodicity in photonic crystals guarantees the crystal's effective energy band structure, which is the fundamental cornerstone of topological and moir & eacute; physics. However, the shear modulus in most fluids is close to zero, which makes it challenging for fluids to maintain spatial periodicity akin to photonic crystals. We realized periodic vortices in hydrodynamic metamaterials and created a bilayer moir & eacute; superlattice by stacking and twisting two such vortex flui...
• Congo's mpox crisis AI翻译
  作者：Cohen, Jon
• A canonical protein complex controls immune homeostasis and multipathogen resistance AI翻译
  作者：Wu, Yue; Xu, Weiying; Zhao, Guoyan; Lei, Ziyao; Li, Kui; Liu, Jiyun; Huang, Shijia; Wang, Junli; Zhong, Xiangbin; Yin, Xin; Wang, Yuandong; Zhang, Haochen; He, Yang; Ye, Zian; Meng, Yonggang; Chang, Xiaoyu; Lin, Hui; Wang, Xin; Gao, Yuanyuan; Chai, Jijie; Parker, Jane E.; Deng, Yiwen; Zhang, Yu; Gao, Mingjun; He, Zuhua
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Fudan University; Westlake University; Max Planck Society; Zhengzhou University; Henan Normal University; Zhejiang University
  摘要：The calcium (Ca2+) sensor ROD1 (RESISTANCE OF RICE TO DISEASES1) is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR (TIR-only protein), OsEDS1 (enhanced disease susceptibility 1), OsPAD4 (phytoalexin deficient 4), and OsADR1 (activated disease resistance 1) all abolish enhanced disease resistance of rod1 plants. OsTIR catalyzes the produ...
• Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing AI翻译
  作者：Lee, Seungjae; Lee, Sangmi; Desnick, Robert; Yasuda, Makiko; Lai, Eric C.
  作者单位：Memorial Sloan Kettering Cancer Center; Icahn School of Medicine at Mount Sinai
  摘要：microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synthase 1 (ALAS1), the initiating enzyme for heme biosynthesis, as a general repressor of miRNA accumulation. Although heme is known to be a positive cofactor for the nuclear miRNA processing machinery, ALAS1-but not other heme biosynthesis enzymes-limits the assembly and activity of Argonaute comple...
• Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice AI翻译
  作者：Li, Wenwen; Li, Jiarui; Li, Jing; Wei, Chen; Laviv, Tal; Dong, Meiyi; Lin, Jingran; Calubag, Mariah; Colgan, Lesley A.; Jin, Kai; Zhou, Bing; Shen, Ying; Li, Haohong; Cui, Yihui; Gao, Zhihua; Li, Tao; Hu, Hailan; Yasuda, Ryohei; Ma, Huan
  作者单位：Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Tel Aviv University; Tel Aviv University; University of Wisconsin System; University of Wisconsin Madison; US Department of Veterans Affairs; Veterans Health Administration (VHA); William S Middleton Memorial Veterans Hospital; Max Planck Society; Beihang University; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-dependent coupling between neuronal and synaptic excitation and mitochondrial DNA transcription (E-TCmito), which operates differently compared to classic excitation-transcription coupling in the nucleus (E-TCnuc). We demonstrated that E-TCmito repu...
• Tolerance on trial AI翻译
  作者：Thorp, H. Holden
• Mysterious radio pulses traced to dance of stellar dwarfs AI翻译
  作者：Clery, Daniel
• A step back, not a setback AI翻译
  作者：Madhumita, Monisha
  作者单位：Saveetha Institute of Medical & Technical Science; Saveetha Medical College & Hospital
• Thermal radiation with a twist AI翻译
  作者：Bharadwaj, Sathwik; Jacob, Zubin
  作者单位：Purdue University System; Purdue University
• Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses AI翻译
  作者：Mallajosyula, Vamsee; Chakraborty, Saborni; Sola, Elsa; Fong, Ryan Furuichi; Shankar, Vishnu; Gao, Fei; Burrell, Allison R.; Gupta, Neha; Wagar, Lisa E.; Mischel, Paul S.; Capasso, Robson; Staat, Mary A.; Chien, Yueh-Hsiu; Dekker, Cornelia L.; Wang, Taia T.; Davis, Mark M.
  作者单位：Stanford University; Stanford University; Stanford University; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University of California System; University of California Irvine; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University
  摘要：The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. By studying a monozygotic twin cohort, we found that although prior exposure is a factor, host genetics are a stronger driver of subtype bias to influenza viral strains. We found that covalent coupling of heterologous hemagglutinin (HA) fr...