Science

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• Drop-printing with dynamic stress release for conformal wrap of bioelectronic interfaces AI翻译
  作者：Li, An; Zhou, Wenjianlong; Li, Huizeng; Fang, Wei; Luo, Yifei; Li, Zheng; Zhang, Qingrong; Liu, Quan; Xu, Qin; Xue, Luanluan; Li, Kaixuan; Yuan, Renxuan; Liu, Wanling; Jia, Wang; Chen, Xiaodong; Song, Yanlin
  作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Capital Medical University; Tianjin University; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); Army Medical University; Army Medical University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanyang Technological University
  摘要：Bioelectronic interfaces demonstrate promising applications in health monitoring, medical treatment, and augmented reality. However, conformally wrapping these film devices onto three-dimensional surfaces often leads to stress-induced damage. We propose a drop-printing strategy that enables damage-free film transfer using a droplet. The droplet acts as a lubricating layer between the film and the target surface, facilitating local sliding during shape-adaptive deformation. This mechanism preve...
• Fragmentation increased in over half of global forests from 2000 to 2020 AI翻译
  作者：Zou, Yibiao; Crowther, Thomas W.; Smith, Gabriel Reuben; Ma, Haozhi; Mo, Lidong; Bialic-Murphy, Lalasia; Potapov, Peter; Gawecka, Klementyna A.; Xu, Chi; Negret, Pablo J.; Lauber, Thomas; Wu, Zhaofei; Rebindaine, Dominic; Zohner, Constantin M.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Nankai University; University System of Maryland; University of Maryland College Park; University of Zurich; UK Centre for Ecology & Hydrology (UKCEH); Nanjing University; University of Bern; Western Sydney University; Beijing Normal University
  摘要：Habitat fragmentation, in which contiguous forests are broken into smaller, isolated patches, threatens biodiversity by disrupting species movement, shrinking populations, and altering ecosystem dynamics. Past assessments suggested declining global fragmentation, but they relied on structure-based metrics that overlook ecological connectivity. We analyzed global forest fragmentation from 2000 to 2020 using complementary metrics that captured patch connectivity, aggregation, and structure. Conn...
• Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex AI翻译
  作者：Dietrich, Melanie H.; Chmielewski, Jill; Chan, Li-Jin; Tan, Li Lynn; Adair, Amy; Lyons, Frankie M. T.; Gabriela, Mikha; Lopaticki, Sash; Dite, Toby A.; Dagley, Laura F.; Pazzagli, Lucia; Gupta, Priya; Kamil, Mohd; Vaughan, Ashley M.; Rojrung, Rattanaporn; Abraham, Anju; Mazhari, Ramin; Longley, Rhea J.; Zeglinski, Kathleen; Gouil, Quentin; Mueller, Ivo; Fabb, Stewart A.; Shandre-Mugan, Rekha; Pouton, Colin W.; Glukhova, Alisa; Shakeel, Shabih; Tham, Wai-Hong
  作者单位：Walter & Eliza Hall Institute; University of Melbourne; University of Melbourne; Peter Doherty Institute; Seattle Children's Hospital; University of Washington; University of Washington Seattle; Ehime University; Mahidol University; La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University; Shanghai Jiao Tong University; Monash University; University of Melbourne; Monash University; Monash University; Australian National University
  摘要：Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/45 proteins are critical for male fertility and transmission of the malaria parasite. They form a core fertilization complex, but it is unknown how they interact. We determined a cryo-electron microscopy structure of the endogenous Pfs230-Pfs48/45 complex showing that Pfs48/45 interacts with Pfs23...
• Fire heat affects the impacts of wildfires on air pollution in the United States AI翻译
  作者：Ma, Qihan; Wei, Linyi; Wang, Yong; Zhang, Guang J.; Zhou, Xinlin; Wang, Bin
  作者单位：Fudan University; Tsinghua University; Chinese Academy of Sciences; Institute of Earth Environment, CAS; University of California System; University of California San Diego; Scripps Institution of Oceanography; Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Conventional wisdom suggests that wildfires in the western United States (WUS) degrade air quality nationwide as a result of aerosol emissions and eastward transport. However, we found that heat produced by wildfires, a commonly neglected effect, can reduce fine particle concentrations (PM2.5) in the eastern United States (EUS) by an amount comparable to the increases in the WUS during the fire season. This phenomenon arises from fire heat-induced convection in the WUS and subsequent downstrea...
• Machine learning-based penetrance of genetic variants AI翻译
  作者：Forrest, Iain S.; Vy, Ha My T.; Rocheleau, Ghislain; Jordan, Daniel M.; Petrazzini, Ben O.; Nadkarni, Girish N.; Cho, Judy H.; Ganapathi, Mythily; Huang, Kuan-Lin; Chung, Wendy K.; Do, Ron
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; NewYork-Presbyterian Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School
  摘要：Accurate variant penetrance estimation is crucial for precision medicine. We constructed machine learning (ML) models for 10 diseases using 1,347,298 participants with electronic health records, then applied them to an independent cohort with linked exome data. Resulting probabilities were used to evaluate ML penetrance of 1648 rare variants in 31 autosomal dominant disease-predisposition genes. ML penetrance was variable across variant classes, but highest for pathogenic and loss-of-function ...
• Vegetation changes the trajectory of river bends AI翻译
  作者：Hasson, Michael; Finotello, Alvise; Ielpi, Alessandro; Lapotre, Mathieu G. A.
  作者单位：Stanford University; University of Padua; University of British Columbia
  摘要：A primary axiom in geoscience is that the evolution of plants drove global changes in river dynamics. Notably, the apparent sinuosity of rivers, derived from the variance of sediment accretion direction measured in rocks, substantially increased when land plants evolved, around 425 million years ago. This led to the hypothesis that the rise of vegetation triggered river meandering. Recent studies of barren, meandering rivers challenge this notion, but the Paleozoic shift in the geometry of riv...
• Classical-decisive quantum internet by integrated photonics AI翻译
  作者：Zhang, Yichi; Broberg, Robert; Zhu, Alan; Li, Gushu; Ge, Li; Smith, Jonathan M.; Feng, Liang
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; City University of New York (CUNY) System; College of Staten Island (CUNY); City University of New York (CUNY) System
  摘要：Classical and quantum technologies have traditionally been viewed as orthogonal, with classical systems being deterministic and quantum systems inherently probabilistic. This distinction hinders the development of a scalable quantum internet even as the global internet continues expanding. We report a classical-decisive quantum internet architecture in which the integration of quantum information into advanced photonic technologies enables efficient entanglement distribution over a commerciall...
• Selection at the GSDMC locus in horses and its implications for human mobility AI翻译
  作者：Liu, Xuexue; Jia, Yaozhen; Pan, Jianfei; Zhang, Yanli; Gong, Ying; Wang, Xintong; Ma, Yuehui; Alvarez, Nadir; Jiang, Lin; Orlando, Ludovic
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Chinese Academy of Agricultural Sciences; University of Geneva; University of Lausanne
  摘要：Horsepower revolutionized human history through enhanced mobility, transport, and warfare. However, the suite of biological traits that reshaped horses during domestication remains unclear. We scanned an extensive horse genome time series for selection signatures at 266 markers associated with key traits. We detected a signature of positive selection at ZFPM1-known to be a modulator of behavior in mice-occurring similar to 5000 years ago (ya), suggesting that taming was one of the earliest ste...
• Seismic evidence for a highly heterogeneous martian mantle AI翻译
  作者：Charalambous, Constantinos; Pike, W. Thomas; Kim, Doyeon; Samuel, Henri; Fernando, Benjamin; Bill, Carys; Lognonne, Philippe; Banerdt, W. Bruce
  作者单位：Imperial College London; Imperial College London; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Johns Hopkins University; University of Oxford; University of Oxford; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
  摘要：A planet's interior is a time capsule, preserving clues to its early history. We report the discovery of kilometer-scale heterogeneities throughout Mars' mantle, detected seismically through pronounced wavefront distortion of energy arriving from deeply probing marsquakes. These heterogeneities, likely remnants of the planet's formation, imply a mantle that has undergone limited mixing driven by sluggish convection. Their size and survival constrain Mars' poorly known mantle rheology, indicati...
• Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control AI翻译
  作者：Grabarczyk, Daniel B.; Ehrmann, Julian F.; Murphy, Paul; Yang, Woo Seok; Kurzbauer, Robert; Bell, Lillie E.; Deszcz, Luiza; Neuhold, Jana; Schleiffer, Alexander; Shulkina, Alexandra; Lee, Juyeon; Shin, Jin Seok; Meinhart, Anton; Versteeg, Gijs A.; Zavodszky, Eszter; Song, Hyun Kyu; Hegde, Ramanujan S.; Clausen, Tim
  作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Vienna Biocenter (VBC); Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Korea University; Vienna Biocenter (VBC); Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); University of Vienna; MRC Laboratory Molecular Biology; Medical University of Vienna; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Eukaryotic cells have evolved sophisticated quality control mechanisms to eliminate aggregation-prone proteins that compromise cellular health. Central to this defense is the ubiquitin-proteasome system, where UBR4 acts as an essential E4 ubiquitin ligase, amplifying degradation marks on defective proteins. Cryo-electron microscopy analysis of UBR4 in complex with its cofactors KCMF1 and CALM1 reveals a massive 1.3-megadalton ring structure, featuring a central substrate-binding arena and flex...