Nature

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• DNA-guided transcription factor interactions extend human gene regulatory code AI翻译
  作者：Xie, Zhiyuan; Sokolov, Ilya; Osmala, Maria; Yue, Xue; Bower, Grace; Pett, J. Patrick; Chen, Yinan; Wang, Kai; Cavga, Ayse Derya; Popov, Alexander; Teichmann, Sarah A.; Morgunova, Ekaterina; Kvon, Evgeny Z.; Yin, Yimeng; Taipale, Jussi
  作者单位：Tongji University; University of Cambridge; Wellcome Trust Sanger Institute; University of Helsinki; University of California System; University of California Irvine; Wellcome Trust Sanger Institute; European Synchrotron Radiation Facility (ESRF); University of Cambridge; Karolinska Institutet; Tongji University
  摘要：In the same way that the mRNA-binding specificities of transfer RNAs define the genetic code, the DNA-binding specificities of transcription factors (TFs) form the molecular basis of the gene regulatory code1,2. The human gene regulatory code is much more complex than the genetic code, in particular because there are more than 1,600 TFs that commonly interact with each other. TF-TF interactions are required for specifying cell fate and executing cell-type-specific transcriptional programs. Des...
• Chicago Archaeopteryx informs on the early evolution of the avian bauplan AI翻译
  作者：O'Connor, Jingmai; Clark, Alexander; Kuo, Pei-Chen; Kiat, Yosef; Fabbri, Matteo; Shinya, Akiko; Van Beek, Constance; Lu, Jing; Wang, Min; Hu, Han
  作者单位：Field Museum of Natural History (Chicago); University of Chicago; Tel Aviv University; Tel Aviv University; Johns Hopkins University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
  摘要：Here we report on the nearly complete and uncrushed 14th specimen of Archaeopteryx. Exceptional preservation and preparation guided by micro-computed tomographic data make this one of the best exemplars of this iconic taxon, preserving important data regarding skeletal transformation and plumage evolution in relation to the acquisition of flight during early avian evolution. The ventrolaterally exposed skull reveals a palatal morphology intermediate between troodontids1 and crownward Cretaceou...
• Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer (vol 615, pg 168, 2023) AI翻译
  作者：Tintelnot, Joseph; Xu, Yang; Lesker, Till R.; Schoenlein, Martin; Konczalla, Leonie; Giannou, Anastasios D.; Pelczar, Penelope; Kylies, Dominik; Puelles, Victor G.; Bielecka, Agata A.; Peschka, Manuela; Cortesi, Filippo; Riecken, Kristoffer; Jung, Maximilian; Amend, Lena; Broering, Tobias S.; Trajkovic-Arsic, Marija; Siveke, Jens T.; Renne, Thomas; Zhang, Danmei; Boeck, Stefan; Strowig, Till; Uzunoglu, Faik G.; Guengoer, Cenap; Stein, Alexander; Izbicki, Jakob R.; Bokemeyer, Carsten; Sinn, Marianne; Kimmelman, Alec C.; Huber, Samuel; Gagliani, Nicola
• Changes in neurotensin signalling drive hedonic devaluation in obesity AI翻译
  作者：Shimoni, Neta Gazit; Tose, Amanda J.; Seng, Charlotte; Jin, Yihan; Lukacsovich, Tamas; Yang, Hongbin; Verharen, Jeroen P. H.; Liu, Christine; Tanios, Michael; Hu, Eric; Read, Jonathan; Tang, Lilly W.; Lim, Byung Kook; Tian, Lin; Foeldy, Csaba; Lammel, Stephan
  作者单位：University of California System; University of California Berkeley; University of Zurich; University of California System; University of California Davis; Zhejiang University; Zhejiang University; University of California System; University of California San Diego; Max Planck Society
  摘要：Calorie-rich foods, particularly those that are high in fat and sugar, evoke pleasure in both humans and animals1. However, prolonged consumption of such foods may reduce their hedonic value, potentially contributing to obesity2, 3-4. Here we investigated this phenomenon in mice on a chronic high-fat diet (HFD). Although these mice preferred high-fat food over regular chow in their home cages, they showed reduced interest in calorie-rich foods in a no-effort setting. This paradoxical decrease ...
• Taking common medicines might matter for cancer treatment AI翻译
  作者：Mahon, Francois-Xavier
  作者单位：UNICANCER; Institut Bergonie
• Encapsulated Co-Ni alloy boosts high-temperature CO2 electroreduction AI翻译
  作者：Ma, Wenchao; Morales-Vidal, Jordi; Tian, Jiaming; Liu, Meng-Ting; Jin, Seongmin; Ren, Wenhao; Taubmann, Julian; Chatzichristodoulou, Christodoulos; Luterbacher, Jeremy; Chen, Hao Ming; Lopez, Nuria; Hu, Xile
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Barcelona Institute of Science & Technology; National Taiwan University; National Taiwan University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Technical University of Denmark
  摘要：Electrochemical CO2 reduction into chemicals and fuels holds great promise for renewable energy storage and carbon recycling1, 2-3. Although high-temperature CO2 electroreduction in solid oxide electrolysis cells is industrially relevant, current catalysts have modest energy efficiency and a limited lifetime at high current densities, generally below 70% and 200 h, respectively, at 1 A cm-2 and temperatures of 800 degrees C or higher4, 5, 6, 7-8. Here we develop an encapsulated Co-Ni alloy cat...
• Psychedelics reduce fear by targeting immune cells that modulate brain cells AI翻译
  作者：Chen, Yun; Colonna, Marco
  作者单位：Washington University (WUSTL); Washington University (WUSTL)
• Global measles eradication goal is urgently needed AI翻译
  作者：Durrheim, David N.; Andrus, Jon K.; Tabassum, Shahina; Githanga, David; Kojouharova, Mira; Teleb, Nadia
  作者单位：University of Newcastle; George Washington University; Bangabandhu Sheikh Mujib Medical University (BSMMU)
• Quasar radiation transforms the gas in a merging companion galaxy AI翻译
  作者：Balashev, Sergei; Noterdaeme, Pasquier; Gupta, Neeraj; Krogager, Jens-Kristian; Combes, Francoise; Lopez, Sebastian; Petitjean, Patrick; Omont, Alain; Srianand, Raghunathan; Cuellar, Rodrigo
  作者单位：Russian Academy of Sciences; St. Petersburg Scientific Centre of the Russian Academy of Sciences; Ioffe Physical Technical Institute; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; Universidad de Chile; Inter-University Centre for Astronomy & Astrophysics; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON); Universite PSL; Observatoire de Paris; Sorbonne Universite; College de France; Centre National de la Recherche Scientifique (CNRS); Universidad de Chile
  摘要：Quasars, powered by gas accretion onto supermassive black holes1,2, rank among the most energetic objects in the Universe3,4. Although they are thought to be ignited by galaxy mergers5, 6, 7, 8, 9, 10-11 and affect the surrounding gas12, 13, 14-15, observational constraints on both processes remain scarce16, 17-18. Here we describe a major merging system at redshift z approximate to 2.7 and demonstrate that radiation from the quasar in one galaxy directly alters the gas properties in the other...
• Why space exploration must not be left to a few powerful nations AI翻译
  作者：Aganaba, Timiebi; Fish, Adam; Hamacher, Duane; Harvey, Alvin; Joinbee, Daniel; Milligan, Anthony; Ojani, Chakad; Smiles, Niiyokamigaabaw Deondre; Swanton, Peter; Neilson, Hilding; Tucker, Brad
  作者单位：Arizona State University; Arizona State University-Tempe; University of New South Wales Sydney; University of Melbourne; Massachusetts Institute of Technology (MIT); University of London; King's College London; Memorial University Newfoundland; Stockholm University; University of British Columbia; Australian National University; Australian National University