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作者:Zhernakova, Daria V.; Wang, Daoming; Liu, Lei; Andreu-Sanchez, Sergio; Zhang, Yue; Ruiz-Moreno, Angel J.; Peng, Haoran; Plomp, Niels; Del Castillo-Izquierdo, Angela; Gacesa, Ranko; Lopera-Maya, Esteban A.; Temba, Godfrey S.; Kullaya, Vesla I.; van Leeuwen, Sander S.; Xavier, Ramnik J.; de Mast, Quirijn; Joosten, Leo A. B.; Riksen, Niels P.; Rutten, Joost H. W.; Netea, Mihai G.; Sanna, Serena; Wijmenga, Cisca; Weersma, Rinse K.; Zhernakova, Alexandra; Harmsen, Hermie J. M.; Fu, Jingyuan
作者单位:University of Groningen; University of Groningen; University of Groningen; University of Groningen; Radboud University Nijmegen; Radboud University Nijmegen; Kilimanjaro Christian Medical Centre; University of Groningen; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Iuliu Hatieganu University of Medicine & Pharmacy; University of Bonn; University of Medicine & Pharmacy of Craiova; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR)
摘要:Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established1-6, little is known about how host genetics regulates the genetic diversity of gut microorganisms. Here we conducted a meta-analysis of associations between human genetic variation and gut microbial structural variation in 9,015 individuals from four Dutch cohorts. Strikingly, the presence rate of a structural variation segment in Faecalibacterium prausnitzii that harbours an ...
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作者:Borra, Chenna Rao
作者单位:Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kharagpur
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作者:Bastien-Olvera, B. A.; Conte, M. N.; Dong, X.; Briceno, T.; Batker, D.; Emmerling, J.; Tavoni, M.; Granella, F.; Moore, F. C.
作者单位:University of California System; University of California Davis; University of California System; University of California San Diego; Scripps Institution of Oceanography; Fordham University; University of California System; University of California Davis; Polytechnic University of Milan
摘要:Ecosystems generate a wide range of benefits for humans, including some market goods as well as other benefits that are not directly reflected in market activity1. Climate change will alter the distribution of ecosystems around the world and change the flow of these benefits2,3. However, the specific implications of ecosystem changes for human welfare remain unclear, as they depend on the nature of these changes, the value of the affected benefits and the extent to which communities rely on na...
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作者:Poletayev, Andrey D.; Hoffmann, Matthias C.; Dawson, James A.; Teitelbaum, Samuel W.; Trigo, Mariano; Islam, M. Saiful; Lindenberg, Aaron M.
作者单位:Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; University of Oxford; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Newcastle University - UK; Newcastle University - UK; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of Bath; Arizona State University; Arizona State University-Tempe
摘要:Predicting practical rates of transport in condensed phases enables the rational design of materials, devices and processes. This is especially critical to developing low-carbon energy technologies such as rechargeable batteries1-3. For ionic conduction, the collective mechanisms4,5, variation of conductivity with timescales6-8 and confinement9,10, and ambiguity in the phononic origin of translation11,12, call for a direct probe of the fundamental steps of ionic diffusion: ion hops. However, s...
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作者:Alig, Stefan K.; Shahrokh Esfahani, Mohammad; Garofalo, Andrea; Li, Michael Yu; Rossi, Cedric; Flerlage, Tim; Flerlage, Jamie E.; Adams, Ragini; Binkley, Michael S.; Shukla, Navika; Jin, Michael C.; Olsen, Mari; Telenius, Adele; Mutter, Jurik A.; Schroers-Martin, Joseph G.; Sworder, Brian J.; Rai, Shinya; King, Daniel A.; Schultz, Andre; Bogeholz, Jan; Su, Shengqin; Kathuria, Karan R.; Liu, Chih Long; Kang, Xiaoman; Strohband, Maya J.; Langfitt, Deanna; Pobre-Piza, Kristine Faye; Surman, Sherri; Tian, Feng; Spina, Valeria; Tousseyn, Thomas; Buedts, Lieselot; Hoppe, Richard; Natkunam, Yasodha; Fornecker, Luc-Matthieu; Castellino, Sharon M.; Advani, Ranjana; Rossi, Davide; Lynch, Ryan; Ghesquieres, Herve; Casasnovas, Olivier; Kurtz, David M.; Marks, Lianna J.; Link, Michael P.; Andre, Marc; Vandenberghe, Peter; Steidl, Christian; Diehn, Maximilian; Alizadeh, Ash A.
作者单位:Stanford University; Universite Bourgogne Europe; CHU Dijon Bourgogne; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Bourgogne Europe; Institut Agro; AgroSup Dijon; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Stanford University; Stanford University; St Jude Children's Research Hospital; KU Leuven; KU Leuven; Stanford University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Emory University; Children's Healthcare of Atlanta (CHOA); Institute of Oncology Research (IOR); Universita della Svizzera Italiana; Fred Hutchinson Cancer Center; CHU Lyon; Universite Catholique Louvain; KU Leuven; University Hospital Leuven
摘要:The scarcity of malignant Hodgkin and Reed-Sternberg cells hampers tissue-based comprehensive genomic profiling of classic Hodgkin lymphoma (cHL). By contrast, liquid biopsies show promise for molecular profiling of cHL due to relatively high circulating tumour DNA (ctDNA) levels1-4. Here we show that the plasma representation of mutations exceeds the bulk tumour representation in most cases, making cHL particularly amenable to noninvasive profiling. Leveraging single-cell transcriptional prof...
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作者:Lenharo, Mariana
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作者:Ledmyr, Helena; Abrams, Mathew; McIntosh, Randy
作者单位:Simon Fraser University
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作者:Lewis, Dyani
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作者:[Anonymous]
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作者:Choras, Michal; Pawlicki, Marek; Kozik, Rafal; Pawlicka, Aleksandra
作者单位:Bydgoszcz University of Science & Technology; University of Warsaw