Nature

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• Structure of human phagocyte NADPH oxidase in the activated state AI翻译
  作者：Liu, Xiaoyu; Shi, Yiting; Liu, Rui; Song, Kangcheng; Chen, Lei
  作者单位：Peking University; Peking University; Peking University; Peking University
  摘要：Phagocyte NADPH oxidase, a protein complex with a core made up of NOX2 and p22 subunits, is responsible for transferring electrons from intracellular NADPH to extracellular oxygen(1). This process generates superoxide anions that are vital for killing pathogens(1). The activation of phagocyte NADPH oxidase requires membrane translocation and the binding of several cytosolic factors(2). However, the exact mechanism by which cytosolic factors bind to and activate NOX2 is not well understood. Her...
• COULD ROVING RESEARCHERS HELP SCIENTISTS TO TAKE LEAVE? AI翻译
  作者：Coombs, Amy
• Consciousness? It's all in the mind AI翻译
  作者：Velazquez, Jose Luis Perez
• Model uncertainty obscures major driver of soil carbon AI翻译
  作者：He, Xianjin; Abramoff, Rose Z.; Abs, Elsa; Georgiou, Katerina; Zhang, Haicheng; Goll, Daniel S.
  作者单位：CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Sun Yat Sen University
• The spy who flunked it: Kurt Godel's forgotten part in the atom-bomb story AI翻译
  作者：Sigmund, Karl
  作者单位：University of Vienna
• I look for the mineral equivalent of tree rings AI翻译
  作者：Li, Yang; Gewin, Virginia
  作者单位：Peking University
• Nuclear morphology is shaped by loop-extrusion programs AI翻译
  作者：Patta, Indumathi; Zand, Maryam; Lee, Lindsay; Mishra, Shreya; Bortnick, Alexandra; Lu, Hanbin; Prusty, Arpita; McArdle, Sara; Mikulski, Zbigniew; Wang, Huan-You; Cheng, Christine S.; Fisch, Kathleen M.; Hu, Ming; Murre, Cornelis
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Cleveland Clinic Foundation; La Jolla Institute for Immunology; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces(1-3). However, how polymorphonuclear structures are assembled remains unknown(4). Here we show that in neutrophil progenitors, halting loop extrusion-a motor-powered process that generates DNA loops by pulling in chromatin(5)-leads to the assembly of polymorphonuclear genomes. Specifically, we found that in mononuclear neutrophil progenitors, acute depletion of ...
• Where I work Yang Li AI翻译
  作者：Gewin, Virginia; Li, Yang
  作者单位：Peking University
• Artificial intelligence and illusions of understanding in scientific research AI翻译
  作者：Messeri, Lisa; Crockett, M. J.
  作者单位：Yale University; Princeton University; Princeton University
  摘要：Scientists are enthusiastically imagining ways in which artificial intelligence (AI) tools might improve research. Why are AI tools so attractive and what are the risks of implementing them across the research pipeline? Here we develop a taxonomy of scientists' visions for AI, observing that their appeal comes from promises to improve productivity and objectivity by overcoming human shortcomings. But proposed AI solutions can also exploit our cognitive limitations, making us vulnerable to illu...
• Earthquakes are most deadly in these unexpected countries AI翻译
  作者：Kulkarni, Sumeet