Nature

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• East-to-west human dispersal into Europe 1.4 million years ago AI翻译
  作者：Garba, R.; Usyk, V.; Yla-Mella, L.; Kamenik, J.; Stuebner, K.; Lachner, J.; Rugel, G.; Veselovsky, F.; Gerasimenko, N.; Herries, A. I. R.; Kucera, J.; Knudsen, M. F.; Jansen, J. D.
  作者单位：Czech Academy of Sciences; Nuclear Physics Institute of the Czech Academy of Sciences; Czech Academy of Sciences; National Academy of Sciences Ukraine; Institute of Archaeology, National Academy of Sciences of Ukraine; Czech Academy of Sciences; Institute of Archaeology of the Czech Academy of Sciences - Brno; Czech Academy of Sciences; Institute of Geophysics of the Czech Academy of Sciences; Charles University Prague; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Czech Geological Survey; Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv; La Trobe University; University of Johannesburg; Aarhus University
  摘要：Stone tools stratified in alluvium and loess at Korolevo, western Ukraine, have been studied by several research groups1-3 since the discovery of the site in the 1970s. Although Korolevo's importance to the European Palaeolithic is widely acknowledged, age constraints on the lowermost lithic artefacts have yet to be determined conclusively. Here, using two methods of burial dating with cosmogenic nuclides4,5, we report ages of 1.42 +/- 0.10 million years and 1.42 +/- 0.28 million years for the...
• 3D-PRINTED WASTE WOOD ACTS JUST LIKE THE REAL THING AI翻译
  作者：[Anonymous]
• Powerful microscopy reveals blood-cell production in bone marrow AI翻译
  作者：Florian, M. Carolina
  作者单位：ICREA
  摘要：A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection.
• Deep-sea mining plans should not be rushed AI翻译
  作者：[Anonymous]
  摘要：Why are companies and governments determined to start commercial-scale mining for rare metals, when so little is known about its wider impacts?
• Substrate-induced condensation activates plant TIR domain proteins AI翻译
  作者：Song, Wen; Liu, Li; Yu, Dongli; Bernardy, Hanna; Jirschitzka, Jan; Huang, Shijia; Jia, Aolin; Jemielniak, Wictoria; Acker, Julia; Laessle, Henriette; Wang, Junli; Shen, Qiaochu; Chen, Weijie; Li, Pilong; Parker, Jane E.; Han, Zhifu; Schulze-Lefert, Paul; Chai, Jijie
  作者单位：China Agricultural University; Max Planck Society; University of Cologne; Beijing Normal University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute; Harvard Medical School; Westlake University; Tsinghua University; Max Planck Society
  摘要：Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-terminal ligand-sensing domains1. Effector binding enables TIR-encoded enzymatic activities that are required for TIR-NLR (TNL)-mediated immunity2,3. Many truncated TNL proteins lack effector-sensing domains but retain similar enzymatic and immune activities4,5. The mechanism underlying t...
• In retrospect 50 years after a landmark paper on bird-flight origins AI翻译
  作者：Padian, Kevin
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
• Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells (Feb, 10.1038/s41586-024-07121-9, 2024) AI翻译
  作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; McGinnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
• The structure and physical properties of a packaged bacteriophage particle AI翻译
  作者：Coshic, Kush; Maffeo, Christopher; Winogradoff, David; Aksimentiev, Aleksei
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：A string of nucleotides confined within a protein capsid contains all the instructions necessary to make a functional virus particle, a virion. Although the structure of the protein capsid is known for many virus species1,2, the three-dimensional organization of viral genomes has mostly eluded experimental probes3,4. Here we report all-atom structural models of an HK97 virion5, including its entire 39,732 base pair genome, obtained through multiresolution simulations. Mimicking the action of a...
• Don't underestimate the rising threat of groundwater to coastal cities AI翻译
  作者：Rozell, Daniel J.
  作者单位：State University of New York (SUNY) System; Stony Brook University
  摘要：Letter to the Editor
• Evolutionary trajectories of small cell lung cancer under therapy AI翻译
  作者：George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Juergens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedues, Balazs; Schuler, Martin; Ploenes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohe, Christian; Serke, Monika; Hoepker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nuernberg, Peter; Becker, Kerstin; Achter, Viktor; Buettner, Reinhard; Wolf, Juergen; Peifer, Martin; Thomas, Roman K.
  作者单位：University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; University of Cologne; RWTH Aachen University; RWTH Aachen University Hospital; University of Cologne; University of Cologne; Goethe University Frankfurt; Goethe University Frankfurt Hospital; Goethe University Frankfurt; Helmholtz Association; German Cancer Research Center (DKFZ); University of Wurzburg; University of Duisburg Essen; University of Duisburg Essen; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Medical University of Vienna; University of Cologne; University of Cologne; University of Bonn; Pius-Hospital Oldenburg; University of Munster; St. Johannes Hospital; University of Duisburg Essen; University of Duisburg Essen; University of Cologne; University of Cologne; University of Cologne
  摘要：The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown1-3. Here we determined tumour phylogenies at diagnosis and throughout chemotherapy and immunotherapy by multiregion sequencing of 160 tumours from 65 patients. Treatment-naive SCLC exhibited clonal homogeneity at distinct tumour sites, whereas first-line platinum-based chemotherapy led to a burst in genomic intratumour heterogeneity and spatial clonal d...