-
作者:[Anonymous]
-
作者:Schappe, Michael S.; Brinn, Philip A.; Joshi, Narendra R.; Greenberg, Rachel S.; Min, Soohong; Alabi, AbdulRasheed A.; Zhang, Chuchu; Liberles, Stephen D.
作者单位:Howard Hughes Medical Institute; Harvard University; Harvard Medical School
摘要:Airway integrity must be continuously maintained throughout life. Sensory neurons guard against airway obstruction and, on a moment-by-moment basis, enact vital reflexes to maintain respiratory function( 1,2 ). Decreased lung capacity is common and life-threatening across many respiratory diseases, and lung collapse can be acutely evoked by chest wall trauma, pneumothorax or airway compression. Here we characterize a neuronal reflex of the vagus nerve evoked by airway closure that leads to gas...
-
作者:Castelvecchi, Davide
摘要:Michel Talagrand laid mathematical groundwork that has allowed others to tackle problems involving random processes.
-
作者:Fang, Wensheng; Guo, Wei; Lu, Ruihu; Yan, Ya; Liu, Xiaokang; Wu, Dan; Li, Fu Min; Zhou, Yansong; He, Chaohui; Xia, Chenfeng; Niu, Huiting; Wang, Sicong; Liu, Youwen; Mao, Yu; Zhang, Chengyi; You, Bo; Pang, Yuanjie; Duan, Lele; Yang, Xuan; Song, Fei; Zhai, Tianyou; Wang, Guoxiong; Guo, Xingpeng; Tan, Bien; Yao, Tao; Wang, Ziyun; Xia, Bao Yu
-
作者:Owusu-Gyamfi, Sandra
-
作者:[Anonymous]
-
作者:Sun, Yida; Zhu, Shupeng; Wang, Daoping; Duan, Jianping; Lu, Hui; Yin, Hao; Tan, Chang; Zhang, Lingrui; Zhao, Mengzhen; Cai, Wenjia; Wang, Yong; Hu, Yixin; Tao, Shu; Guan, Dabo
作者单位:Tsinghua University; Zhejiang University; University of California System; University of California Irvine; University of London; King's College London; University of Cambridge; Beijing Normal University; Tsinghua University; University of Southern California; University of Waterloo; Beijing Institute of Technology; Southeast University - China; Peking University; University of London; University College London
摘要:Evidence shows a continuing increase in the frequency and severity of global heatwaves1,2, raising concerns about the future impacts of climate change and the associated socioeconomic costs3,4. Here we develop a disaster footprint analytical framework by integrating climate, epidemiological and hybrid input-output and computable general equilibrium global trade models to estimate the midcentury socioeconomic impacts of heat stress. We consider health costs related to heat exposure, the value o...
-
作者:Li, Ningning; Gao, Yuan; Zhang, Yujie; Yu, Daqi; Lin, Jianwei; Feng, Jianxun; Li, Jian; Xu, Zhichun; Zhang, Yingyi; Dang, Shangyu; Zhou, Keda; Liu, Yang; Li, Xiang David; Tye, Bik Kwoon; Li, Qing; Gao, Ning; Zhai, Yuanliang
作者单位:Peking University; University of Hong Kong; Peking University; Peking University; Hong Kong University of Science & Technology; University of Hong Kong; Hong Kong University of Science & Technology; University of Hong Kong; Cornell University
摘要:In eukaryotes, DNA compacts into chromatin through nucleosomes(1,2). Replication of the eukaryotic genome must be coupled to the transmission of the epigenome encoded in the chromatin(3,4). Here we report cryo-electron microscopy structures of yeast (Saccharomyces cerevisiae) replisomes associated with the FACT (facilitates chromatin transactions) complex (comprising Spt16 and Pob3) and an evicted histone hexamer. In these structures, FACT is positioned at the front end of the replisome by eng...
-
作者:Irwin, Aisling
摘要:A popular theory about how trees cooperate has enchanted the public and raised the profile of forest conservation. But some ecologists think its scientific basis has been oversold.
-
作者:Lee, Hong-Gyun; Rone, Joseph M.; Li, Zhaorong; Akl, Camilo Faust; Shin, Seung Won; Lee, Joon-Hyuk; Flausino, Lucas E.; Pernin, Florian; Chao, Chun-Cheih; Kleemann, Kilian L.; Srun, Lena; Illouz, Tomer; Giovannoni, Federico; Charabati, Marc; Sanmarco, Liliana M.; Kenison, Jessica E.; Piester, Gavin; Zandee, Stephanie E. J.; Antel, Jack P.; Rothhammer, Veit; Wheeler, Michael A.; Prat, Alexandre; Clark, Iain C.; Quintana, Francisco J.
作者单位:Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Berkeley; McGill University; University of Portsmouth; University of Rochester; Universite de Montreal; University of Erlangen Nuremberg
摘要:Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1-8 (EAE), an experimental model for multiple sclerosis. However, little is known about the stability of these astrocyte subsets and their ability to integrate past stimulation events. Here we report the identification of an epigenetically controlled memory astrocyte subset that exhibits exacerbated pro-inflammatory responses upon re...