-
作者：Nichakawade, Tushar D.; Ge, Jiaxin; Mog, Brian J.; Lee, Bum Seok; Pearlman, Alexander H.; Hwang, Michael S.; Dinapoli, Sarah R.; Wyhs, Nicolas; Marcou, Nikita; Glavaris, Stephanie; Konig, Maximilian F.; Gabelli, Sandra B.; Watson, Evangeline; Sterling, Cole; Wagner-Johnston, Nina; Rozati, Sima; Swinnen, Lode; Fuchs, Ephraim; Pardoll, Drew M.; Gabrielson, Kathy; Papadopoulos, Nickolas; Bettegowda, Chetan; Kinzler, Kenneth W.; Zhou, Shibin; Sur, Surojit; Vogelstein, Bert; Paul, Suman
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Roche Holding; Roche Holding USA; Genentech; Merck & Company; Merck & Company USA
摘要：Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1-9. Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short survival10,11 and lack such targeted therapies. Thus, T cell cancers particularly warrant the development of CAR T cells and antibodies to improve patient outcomes. Preclinical studies showed that targeting T cell receptor beta-chain constant reg...
-
作者：Fang, Yuan; Bansal, Kushagra; Mostafavi, Sara; Benoist, Christophe; Mathis, Diane
作者单位：Harvard University; Harvard Medical School; Harvard University; Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); University of Washington; University of Washington Seattle; Canadian Institute for Advanced Research (CIFAR)
摘要：AIRE is an unconventional transcription factor that enhances the expression of thousands of genes in medullary thymic epithelial cells and promotes clonal deletion or phenotypic diversion of self-reactive T cells1-4. The biological logic of AIRE's target specificity remains largely unclear as, in contrast to many transcription factors, it does not bind to a particular DNA sequence motif. Here we implemented two orthogonal approaches to investigate AIRE's cis-regulatory mechanisms: construction...
-
作者：Wells, Sarah
摘要：As educators debate whether it's even possible to use AI safely in research and education, students are taking a role in shaping its responsible use.
-
作者：Tsui, Yen-Chen; He, Minhao; Hu, Yuwen; Lake, Ethan; Wang, Taige; Watanabe, Kenji; Taniguchi, Takashi; Zaletel, Michael P.; Yazdani, Ali
作者单位：Princeton University; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; National Institute for Materials Science; National Institute for Materials Science
摘要：Wigner predicted that when the Coulomb interactions between electrons become much stronger than their kinetic energy, electrons crystallize into a closely packed lattice1. A variety of two-dimensional systems have shown evidence for Wigner crystals2-11 (WCs). However, a spontaneously formed classical or quantum WC has never been directly visualized. Neither the identification of the WC symmetry nor direct investigation of its melting has been accomplished. Here we use high-resolution scanning ...
-
作者：Zepeda-Rivera, Martha; Minot, Samuel S.; Bouzek, Heather; Wu, Hanrui; Blanco-Miguez, Aitor; Manghi, Paolo; Jones, Dakota S.; LaCourse, Kaitlyn D.; Wu, Ying; McMahon, Elsa F.; Park, Soon-Nang; Lim, Yun K.; Kempchinsky, Andrew G.; Willis, Amy D.; Cotton, Sean L.; Yost, Susan C.; Sicinska, Ewa; Kook, Joong-Ki; Dewhirst, Floyd E.; Segata, Nicola; Bullman, Susan; Johnston, Christopher D.
作者单位：Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of Trento; Chosun University; Chosun University; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Forsyth Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard School of Dental Medicine
摘要：Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals(1), is enriched in human colorectal cancer (CRC) tumours(2-5). High intratumoural Fn loads are associated with recurrence, metastases and poorer patient prognosis(5-8). Here, to delineate Fn genetic factors facilitating tumour colonization, we generated closed genomes for 135 Fn strains; 80 oral strains from individuals without cancer and 55 uni...
-
作者：Agnew, Duncan Carr
作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography
摘要：The historical association of time with the rotation of Earth has meant that Coordinated Universal Time (UTC) closely follows this rotation(1). Because the rotation rate is not constant, UTC contains discontinuities (leap seconds), which complicates its use in computer networks(2). Since 1972, all UTC discontinuities have required that a leap second be added(3). Here we show that increased melting of ice in Greenland and Antarctica, measured by satellite gravity(4,5), has decreased the angular...
-
作者：Goodman, Jonathan R.
作者单位：University of Cambridge
摘要：How humans, animals and even single-celled organisms cooperate to survive suggests there's more to life than just competition, argues a cheering study of evolutionary biology.
-
作者：[Anonymous]
摘要：People who had the most vegetation near their residences were the least likely to report depression and anxiety.
-
作者：Howlett, Joseph
摘要：Convincing evidence of 1:1 tidal locking had been absent until a new analysis of the exoplanet LHS 3844b. Convincing evidence of 1:1 tidal locking has been absent until a new analysis of the exoplanet LHS 3855b.
-
作者：Vilas, Nathaniel B.; Robichaud, Paige; Hallas, Christian; Li, Grace K.; Anderegg, Loic; Doyle, John M.
作者单位：Harvard University; Harvard University
摘要：Polyatomic molecules have rich structural features that make them uniquely suited to applications in quantum information science1-3, quantum simulation4-6, ultracold chemistry7 and searches for physics beyond the standard model8-10. However, a key challenge is fully controlling both the internal quantum state and the motional degrees of freedom of the molecules. Here we demonstrate the creation of an optical tweezer array of individual polyatomic molecules, CaOH, with quantum control of their ...
