Nature

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• Nanoscale scythe cuts molecular tethers using mechanical forces AI翻译
  作者：Nierengarten, Iwona
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS)
  摘要：Nanoscale systems that release small molecules have potential therapeutic and industrial uses, but can result in low numbers of molecules reaching their target. A release system triggered by mechanical force offers a fresh approach.
• Phase-change memory via a phase-changeable self-confined nano-filament AI翻译
  作者：Park, See-On; Hong, Seokman; Sung, Su-Jin; Kim, Dawon; Seo, Seokho; Jeong, Hakcheon; Park, Taehoon; Cho, Won Joon; Kim, Jeehwan; Choi, Shinhyun
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Samsung Electronics; Samsung; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Phase-change memory (PCM) has been considered a promising candidate for solving von Neumann bottlenecks owing to its low latency, non-volatile memory property and high integration density1,2. However, PCMs usually require a large current for the reset process by melting the phase-change material into an amorphous phase, which deteriorates the energy efficiency2-5. Various studies have been conducted to reduce the operation current by minimizing the device dimensions, but this increases the fab...
• AI can help to tailor drugs for Africa - but Africans should lead the way AI翻译
  作者：Turon, Gemma; Njoroge, Mathew; Mulubwa, Mwila; Duran-Frigola, Miquel; Chibale, Kelly
  作者单位：University of Cape Town; University of Cape Town
  摘要：Computational models that require very little data could transform biomedical and drug development research in Africa, as long as infrastructure, trained staff and secure databases are available.
• Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release AI翻译
  作者：Tufan, Turan; Comertpay, Gamze; Villani, Ambra; Nelson, Geoffrey M.; Terekhova, Marina; Kelley, Shannon; Zakharov, Pavel; Ellison, Rochelle M.; Shpynov, Oleg; Raymond, Michael; Sun, Jerry; Chen, Yitan; Bockelmann, Enno; Stremska, Marta; Peterson, Lance W.; Boeckaerts, Laura; Goldman, Seth R.; Etchegaray, J. Iker; Artyomov, Maxim N.; Peri, Francesca; Ravichandran, Kodi S.
  作者单位：Washington University (WUSTL); University of Zurich; Harvard University; Harvard Medical School; University of Virginia; University of Virginia; Washington University (WUSTL); Flanders Institute for Biotechnology (VIB); Ghent University; Ghent University
  摘要：During development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis1. How macrophages may rapidly adapt their transcription to achieve continuous corpse uptake is incompletely understood. Transcriptional pause/release is an evolutionarily conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released ...
• We need new rules as AI infiltrates elections AI翻译
  作者：Chowdhury, Rumman
• MRNA DRUG OFFERS HOPE FOR TREATING A DEVASTATING CHILDHOOD DISEASE AI翻译
  作者：Dolgin, Elie
  摘要：Drug trial results show that vaccines aren't the only use for the mRNA technology behind the most widely used COVID-19 jabs.
• Single-cell multiplex chromatin and RNA interactions in ageing human brain AI翻译
  作者：Wen, Xingzhao; Luo, Zhifei; Zhao, Wenxin; Calandrelli, Riccardo; Nguyen, Tri C.; Wan, Xueyi; Richard, John Lalith Charles; Zhong, Sheng
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Dynamically organized chromatin complexes often involve multiplex chromatin interactions and sometimes chromatin-associated RNA 1-3 . Chromatin complex compositions change during cellular differentiation and ageing, and are expected to be highly heterogeneous among terminally differentiated single cells 4-7 . Here we introduce the multinucleic acid interaction mapping in single cells (MUSIC) technique for concurrent profiling of multiplex chromatin interactions, gene expression and RNA-chromat...
• Mammalian cells repress random DNA that yeast transcribes AI翻译
  作者：Eddy, Sean R.
  作者单位：Harvard University; Harvard University; Howard Hughes Medical Institute
  摘要：In experiments dubbed the Random Genome Project, researchers have integrated DNA strands with random sequences into yeast and mouse cells to find the default transcriptional state of their genomes.
• Advanced CRISPR system fixes a deadly mutation in cells AI翻译
  作者：[Anonymous]
  摘要：Applying a 'base editor' allows cells to crank out increased levels of a vital metabolic enzyme.
• Triple-junction solar cells with cyanate in ultrawide-bandgap perovskites AI翻译
  作者：Liu, Shunchang; Lu, Yue; Yu, Cao; Li, Jia; Luo, Ran; Guo, Renjun; Liang, Haoming; Jia, Xiangkun; Guo, Xiao; Wang, Yu-Duan; Zhou, Qilin; Wang, Xi; Yang, Shaofei; Sui, Manling; Mueller-Buschbaum, Peter; Hou, Yi
  作者单位：National University of Singapore; National University of Singapore; Beijing University of Technology; Technical University of Munich; Technical University of Munich
  摘要：Perovskite bandgap tuning without quality loss makes perovskites unique among solar absorbers, offering promising avenues for tandem solar cells1,2. However, minimizing the voltage loss when their bandgap is increased to above 1.90 eV for triple-junction tandem use is challenging3-5. Here we present a previously unknown pseudohalide, cyanate (OCN-), with a comparable effective ionic radius (1.97 angstrom) to bromide (1.95 angstrom) as a bromide substitute. Electron microscopy and X-ray scatter...