8118期

最新文章

• Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes AI翻译
  作者：Kilic, Zeynep Ilgin; van Loenhout, Joyce; Chaillet, Marten; van Es, Robert M.; Sobrevals Alcaraz, Paula; Vos, Harmjan R.; Noteborn, Willem E. M.; Leung, Miguel Ricardo
  作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Utrecht University; Utrecht University Medical Center; Leiden University; Leiden University - Excl LUMC
  摘要：Mammalian oocytes store proteins for embryonic development on abundant structures called cytoplasmic lattices (CPLs)(1). However, the mechanisms by which they achieve this are unclear, largely because the molecular composition of the lattices themselves is unknown. Here we use cryo-electron microscopy and artificial intelligence-based modelling to reveal the molecular architecture and protein composition of native CPLs from mouse oocytes. We find that CPLs are formed by at least 13 different p...
• Aversive learning hijacks a brain sugar sensor to consolidate memory AI翻译
  作者：Frances, Raquel; Comyn, Typhaine; Desnous, Coraline; Bettoni, Francesca; Pavlowsky, Alice; Preat, Thomas; Placais, Pierre-Yves
  作者单位：Universite PSL; Centre National de la Recherche Scientifique (CNRS); Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI)
  摘要：The formation of food-related memories involves post-ingestion nutrient sensing signals1, 2, 3, 4-5. Whether nutrient sensors act beyond feeding-relevant behaviour is less well understood. Here we show that an internal sugar sensor in the Drosophila brain6 is involved in memory consolidation, both in fasted flies subjected to an appetitive learning task involving a sucrose reward and in flies fed ad libitum subjected to an aversive learning task independent of food cues7,8. In the latter, spac...
• Bridget Ogilvie (1938-2026) parasitologist who championed biomedical labs and scientific evidence AI翻译
  作者：Cooke, Anne
  作者单位：University of Cambridge
• Sustainability or dystopia? What past patterns tell us about where society is heading AI翻译
  作者：McKay, David Armstrong
  作者单位：University of Sussex
• Fifty years since a simple equation described the chaos of biology AI翻译
  作者：Stumpf, Michael P. H.; Laidlaw, Zoe
  作者单位：University of Melbourne; University of Melbourne; University of Melbourne
• The best way to start your day? The science backs naked cartwheels in the sun AI翻译
  作者：Thompson, Gareth
• Structure of the mouse cytoplasmic lattice AI翻译
  作者：Chi, Pengliang; Wang, Xiang; Li, Jialu; Huang, Jingrui; Ju, Sicheng; Liu, Sibei; Yan, Li; Lu, Yuechao; Zhang, Zihan; Han, Zhuo; Li, Jinhong; Qi, Qianqian; Liu, Qingting; Zeng, Yiren; Guo, Li; Zhang, Xiaofeng; Gui, Long; Deng, Dong
  作者单位：Sichuan University; Sichuan University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shenzhen Medical Academy of Research & Translation (SMART); Sichuan University; Sichuan University
  摘要：The fertilized egg relies almost entirely on maternal stores in the oocyte to ensure the successful initiation of development1. The cytoplasmic lattices (CPLs) in mammalian oocytes store maternal-expressed proteins and have an essential role in embryogenesis2,3. Impairing multiple CPL members leads to early embryonic arrest, resulting in infertility in mammals. However, the mechanism underlying the assembly and storage of CPLs remains largely unknown. Here we report the cryo-electron microscop...
• Polymarket vs science: why researchers are sceptical of the prediction-market hype AI翻译
  作者：Ahart, Jenna
• Microsoft upgrades controversial quantum chip - researchers are still sceptical AI翻译
  作者：Castelvecchi, Davide
• Improved quantum processor logical error rates via correction and detection AI翻译
  作者：Paetznick, A.; Reichardt, B. W.; da Silva, M. P.; Ryan-Anderson, C.; Aasen, D.; Bello-Rivas, J. M.; Campora, J. P.; Chao, R.; Chernoguzov, A.; van Dam, W.; Dreiling, J. M.; Foltz, C.; Frachon, F.; Gaebler, J. P.; Gatterman, T. M.; Grans-Samuelsson, L.; Gresh, D.; Hayes, D.; Hewitt, N.; Holliman, C.; Horst, C. V.; Johansen, J.; Lucchetti, D.; Matsuoka, Y.; Mills, M.; Moses, S. A.; Neyenhuis, B.; Paz, A.; Pino, J.; Siegfried, P.; Sundaram, A.; Tom, D.; Wang, Z.; Wernli, S. J.; Zanner, M.; Stutz, R. P.; Svore, K. M.
  摘要：Performing quantum algorithms for critical problems in physics and chemistry requires substantially lower error rates than the physical error rates of present quantum computers. Achieving such low logical error rates requires quantum error correction1,2 and physical error rates below a critical threshold value3, 4, 5, 6, 7-8. We experimentally demonstrate on a trapped-ion quantum charge-coupled device (QCCD)9,10 improvements in logical error rates ranging from 11 & times; to 800 & times; compa...