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作者:Kilic, Zeynep Ilgin; van Loenhout, Joyce; Chaillet, Marten; van Es, Robert M.; Sobrevals Alcaraz, Paula; Vos, Harmjan R.; Noteborn, Willem E. M.; Leung, Miguel Ricardo
作者单位:Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Utrecht University; Utrecht University Medical Center; Leiden University; Leiden University - Excl LUMC
摘要:Mammalian oocytes store proteins for embryonic development on abundant structures called cytoplasmic lattices (CPLs)(1). However, the mechanisms by which they achieve this are unclear, largely because the molecular composition of the lattices themselves is unknown. Here we use cryo-electron microscopy and artificial intelligence-based modelling to reveal the molecular architecture and protein composition of native CPLs from mouse oocytes. We find that CPLs are formed by at least 13 different p...
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作者:Frances, Raquel; Comyn, Typhaine; Desnous, Coraline; Bettoni, Francesca; Pavlowsky, Alice; Preat, Thomas; Placais, Pierre-Yves
作者单位:Universite PSL; Centre National de la Recherche Scientifique (CNRS); Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI)
摘要:The formation of food-related memories involves post-ingestion nutrient sensing signals1, 2, 3, 4-5. Whether nutrient sensors act beyond feeding-relevant behaviour is less well understood. Here we show that an internal sugar sensor in the Drosophila brain6 is involved in memory consolidation, both in fasted flies subjected to an appetitive learning task involving a sucrose reward and in flies fed ad libitum subjected to an aversive learning task independent of food cues7,8. In the latter, spac...
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作者:Cooke, Anne
作者单位:University of Cambridge
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作者:McKay, David Armstrong
作者单位:University of Sussex
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作者:Stumpf, Michael P. H.; Laidlaw, Zoe
作者单位:University of Melbourne; University of Melbourne; University of Melbourne
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作者:Thompson, Gareth
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作者:Chi, Pengliang; Wang, Xiang; Li, Jialu; Huang, Jingrui; Ju, Sicheng; Liu, Sibei; Yan, Li; Lu, Yuechao; Zhang, Zihan; Han, Zhuo; Li, Jinhong; Qi, Qianqian; Liu, Qingting; Zeng, Yiren; Guo, Li; Zhang, Xiaofeng; Gui, Long; Deng, Dong
作者单位:Sichuan University; Sichuan University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shenzhen Medical Academy of Research & Translation (SMART); Sichuan University; Sichuan University
摘要:The fertilized egg relies almost entirely on maternal stores in the oocyte to ensure the successful initiation of development1. The cytoplasmic lattices (CPLs) in mammalian oocytes store maternal-expressed proteins and have an essential role in embryogenesis2,3. Impairing multiple CPL members leads to early embryonic arrest, resulting in infertility in mammals. However, the mechanism underlying the assembly and storage of CPLs remains largely unknown. Here we report the cryo-electron microscop...
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作者:Ahart, Jenna
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作者:Castelvecchi, Davide
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作者:Paetznick, A.; Reichardt, B. W.; da Silva, M. P.; Ryan-Anderson, C.; Aasen, D.; Bello-Rivas, J. M.; Campora, J. P.; Chao, R.; Chernoguzov, A.; van Dam, W.; Dreiling, J. M.; Foltz, C.; Frachon, F.; Gaebler, J. P.; Gatterman, T. M.; Grans-Samuelsson, L.; Gresh, D.; Hayes, D.; Hewitt, N.; Holliman, C.; Horst, C. V.; Johansen, J.; Lucchetti, D.; Matsuoka, Y.; Mills, M.; Moses, S. A.; Neyenhuis, B.; Paz, A.; Pino, J.; Siegfried, P.; Sundaram, A.; Tom, D.; Wang, Z.; Wernli, S. J.; Zanner, M.; Stutz, R. P.; Svore, K. M.
摘要:Performing quantum algorithms for critical problems in physics and chemistry requires substantially lower error rates than the physical error rates of present quantum computers. Achieving such low logical error rates requires quantum error correction1,2 and physical error rates below a critical threshold value3, 4, 5, 6, 7-8. We experimentally demonstrate on a trapped-ion quantum charge-coupled device (QCCD)9,10 improvements in logical error rates ranging from 11 & times; to 800 & times; compa...