8131期

最新文章

• Special delivery: bacterial couriers are smuggling drugs into cancers AI翻译
  作者：Drew, Liam
• Late-life semaglutide treatment slows ageing and extends lifespan in female mice AI翻译
  作者：Feng, Yufan; Barthez, Marine; Wang, Yifei; Chen, Yibing; Qiu, Huixian; Wang, Chih-Ling; Heydari, Kartoosh; Delcroix, Melaine; Rasmussen, Lene Juel; Bohr, Vilhelm A.; Chen, Danica
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Copenhagen; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); University of Copenhagen
  摘要：Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity1. The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control2, 3, 4-5, but little is known about the underlying basis of the pleiotropic effects. Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of...
• Sideline vested interests to reform China's research AI翻译
  作者：Zhang, Qilin
  作者单位：Southwest University - China
• CRISPR therapy cuts cholesterol for at least 12 months AI翻译
  作者：[Anonymous]
• Glucose-responsive probiotics for glycaemic modulation in mice and monkeys AI翻译
  作者：Guan, Ningzi; Kong, Deqiang; Gao, Xianyun; Niu, Lingxue; Zhou, Yang; Yu, Guiling; Gao, Tian; Liu, Mengyao; Ma, Wenbo; Jin, Yiyu; Yin, Jianli; Zhao, Shangang; Ye, Haifeng
  作者单位：East China Normal University; East China Normal University; University of Texas System; University of Texas at San Antonio
  摘要：Sustained and controlled delivery of glucose-lowering agents using engineered designer cells is recognized as an effective strategy for diabetes therapy1. However, current technologies rely on external signal control or have been programmed into mammalian cells using synthetic gene networks, which pose safety concerns arising from transplantation2,3. Here we developed an engineered oral-deliverable glucose-sensing and functional response probiotic living drug for 'sense-and-respond'-based cont...
• The World Bank is right to prioritize reproducibility AI翻译
  作者：[Anonymous]
• How to make your science business succeed when you're a female founder Sexist assumptions and a male-dominated culture can make it harder for women to attract investment for the companies they set up. AI翻译
  作者：Brazil, Rachel
• Why we need an International Panel on Inequality AI翻译
  作者：Stiglitz, Joseph E.; Abdenur, Adriana E.; Byanyima, Winnie; Ghosh, Jayati; Valodia, Imraan; Zembe-Mkabile, Wanga
  作者单位：Columbia University; UNAIDS; University of Massachusetts System; University of Massachusetts Amherst; University of Witwatersrand; University of Witwatersrand; University of the Western Cape
• Vaporization trick resolves solar-cell bottleneck AI翻译
  作者：Paetzold, Ulrich W.; Fassl, Paul
  作者单位：Helmholtz Association; Karlsruhe Institute of Technology; Helmholtz Association; Karlsruhe Institute of Technology
• The past and future impact of climate change on childhood malaria in Africa AI翻译
  作者：Carlson, Colin J.; Carleton, Tamma; Odoulami, Romaric C.; Molitor, Cullen D.; Trisos, Christopher H.
  作者单位：Yale University; Yale University; Yale University; University of California System; University of California Berkeley; National Bureau of Economic Research; University of California System; University of California Berkeley; University of Cape Town
  摘要：Despite recent advances in climate change attribution, many health impacts remain unmeasured1. Here we leverage over a century of clinical data2 to investigate whether human-caused climate change has increased the burden of childhood malaria across sub-Saharan Africa. We find a robust effect of temperature and extreme precipitation on prevalence, consistent with previous findings at local scales and in laboratory experiments. We estimate that rising temperatures have probably increased malaria...