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作者:Drew, Liam
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作者:Feng, Yufan; Barthez, Marine; Wang, Yifei; Chen, Yibing; Qiu, Huixian; Wang, Chih-Ling; Heydari, Kartoosh; Delcroix, Melaine; Rasmussen, Lene Juel; Bohr, Vilhelm A.; Chen, Danica
作者单位:University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Copenhagen; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); University of Copenhagen
摘要:Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity1. The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control2, 3, 4-5, but little is known about the underlying basis of the pleiotropic effects. Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of...
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作者:Zhang, Qilin
作者单位:Southwest University - China
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作者:[Anonymous]
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作者:Guan, Ningzi; Kong, Deqiang; Gao, Xianyun; Niu, Lingxue; Zhou, Yang; Yu, Guiling; Gao, Tian; Liu, Mengyao; Ma, Wenbo; Jin, Yiyu; Yin, Jianli; Zhao, Shangang; Ye, Haifeng
作者单位:East China Normal University; East China Normal University; University of Texas System; University of Texas at San Antonio
摘要:Sustained and controlled delivery of glucose-lowering agents using engineered designer cells is recognized as an effective strategy for diabetes therapy1. However, current technologies rely on external signal control or have been programmed into mammalian cells using synthetic gene networks, which pose safety concerns arising from transplantation2,3. Here we developed an engineered oral-deliverable glucose-sensing and functional response probiotic living drug for 'sense-and-respond'-based cont...
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作者:[Anonymous]
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作者:Brazil, Rachel
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作者:Stiglitz, Joseph E.; Abdenur, Adriana E.; Byanyima, Winnie; Ghosh, Jayati; Valodia, Imraan; Zembe-Mkabile, Wanga
作者单位:Columbia University; UNAIDS; University of Massachusetts System; University of Massachusetts Amherst; University of Witwatersrand; University of Witwatersrand; University of the Western Cape
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作者:Paetzold, Ulrich W.; Fassl, Paul
作者单位:Helmholtz Association; Karlsruhe Institute of Technology; Helmholtz Association; Karlsruhe Institute of Technology
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作者:Carlson, Colin J.; Carleton, Tamma; Odoulami, Romaric C.; Molitor, Cullen D.; Trisos, Christopher H.
作者单位:Yale University; Yale University; Yale University; University of California System; University of California Berkeley; National Bureau of Economic Research; University of California System; University of California Berkeley; University of Cape Town
摘要:Despite recent advances in climate change attribution, many health impacts remain unmeasured1. Here we leverage over a century of clinical data2 to investigate whether human-caused climate change has increased the burden of childhood malaria across sub-Saharan Africa. We find a robust effect of temperature and extreme precipitation on prevalence, consistent with previous findings at local scales and in laboratory experiments. We estimate that rising temperatures have probably increased malaria...