作者：Simo, Cristina; Vanover, Alexander C.; Albanus, Ricardo D'Oliveira; Panikar, Sandeep Surendra; Shmuel, Shayla; Benton, Alex; Giraldo-Guzman, Jader; Luna, Jose M.; Xu, Yifei; Berry, Na-Keysha; Keltee, Nai; Liu, Jingxia; Dehdashti, Farrokh; Pereira, Patricia M. R.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Siteman Cancer Center; Barnes-Jewish Hospital; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Antibody-drug conjugates (ADCs) have significantly advanced cancer therapy by enabling the selective delivery of cytotoxic agents to tumour cells. However, ADC efficacy remains constrained by its dependence on a single target antigen, which limits tumour targeting and promotes resistance in heterogeneous tumours with variable and low antigen expression1, 2, 3, 4, 5-6. Here we introduce an in vivo bioorthogonal ligation strategy that generates functional antibody-ADC click constructs following ...
作者：Fang, Yuan; Guo, Siying; Du, Jun; Li, Ning
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
作者：Chiappe, Luis M.; Navalon, Guillermo; Martinelli, Agustin G.; Carvalho, Ismar de Souza; Santucci, Rodrigo Miloni; Wu, Yun-Hsin; Field, Daniel J.
