6785期

最新文章

• The Intimate Animal: The Science of Sex, Fidelity, and Why We Live and Die for Love AI翻译
  作者：Brooks, Robert C.
  作者单位：University of New South Wales Sydney; University of New South Wales Sydney
• The ovarian stroma as a therapeutic target AI翻译
  作者：Duncan, Francesca E.; Babayev, Elnur
  作者单位：Northwestern University; Feinberg School of Medicine; Buck Institute for Research on Aging
• Silicon cyclopentadienides featuring a nonplanar 6π aromatic Si5 ring AI翻译
  作者：Iwamoto, Takeaki; Ishikawa, Tomoki; Ishida, Shintaro
  作者单位：Tohoku University
  摘要：Compared with the wide variety of reports on carbon pi-electron compounds, the silicon counterparts remain scarce because of the intrinsic preference of silicon to form sigma-bonded compounds. In particular, silicon compounds in which pi-electrons are delocalized over five or more silicon atoms have been elusive. We report the synthesis of pentasilicon analogs of cyclopentadienides (pentasilacyclopentadienides). These compounds contain nonplanar five-membered silicon rings with some pyramidali...
• Patchy peptide particles for pH-responsive assembly into liquid crystals or lattices AI翻译
  作者：Tang, Yao; Zhang, Tianren; Yang, Dai-Bei; Schwartz, Jacob; Kloxin, Christopher J.; Saven, Jeffery G.; Pochan, Darrin J.
  作者单位：University of Delaware; University of Pennsylvania; University of Delaware
  摘要：Programmable control of protein or colloidal nanoparticle self-assembly into targeted nanostructures, while maintaining stability across extreme pH conditions, remains a major challenge. We designed coiled-coil bundlemer peptide nanoparticles that form ordered, hierarchical materials across an unusually broad pH range (1, 7, and 14) dependent on patchy surface charge display. Nematic liquid crystal formation was observed at low concentration (similar to 0.5 to 4 weight %) at pH 1 and pH 14, wh...
• Zwitterionic organoboron complexes for overcoming the concentration barrier in chemical protein synthesis AI翻译
  作者：Schilling, Philipp E.; Steiner, Samuel; Bode, Jeffrey W.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Stanford University; Stanford Medicine
  摘要：Chemical protein synthesis enables the construction of specific protein architectures but is limited to millimolar reaction concentrations, restricting access to poorly soluble proteins. Potassium acyltrifluoroboronates (KATs) offer a promising alternative through fast and chemoselective amide bond formation, but their application to protein synthesis has been precluded by the lack of a masking strategy. We report chiral, zwitterionic organoboron complexes that mask amino acid-derived KATs. Th...
• What is causing the methane surge? AI翻译
  作者：Nisbet, Euan G.; Manning, Martin R.
  作者单位：University of London; Victoria University Wellington
• Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes AI翻译
  作者：Jiang, Xin; Schaeffer, Laure; Patni, Divya; Russo, Tommaso; Lee, Chao-Zong; Aguilar, Corey; Marques, Christine; Jansen-West, Karen; Hruska-Plochan, Marian; Ray-Soni, Ananya; Lim, Su Min; Held, Aaron; Yue, Mei; Castellanos Otero, Paula; Aryal, Sandeep; Beaussant, Hortense D. A. M.; Basu, Himanish; Takakuwa, Hiro; Daughrity, Lillian M.; Ramesh, Nandini; Da Costa, Paulo; A. A. Quadros, Ana Rita; Nolan, Matthew; Reyes, Charles Jourdan F.; Wheeler, Hayden; Moran, Laura C.; Griesman, Grant; Wymann, Benjamin; Trombetta, Bianca A.; Lopez-De-Silanes, Emma Sofia; Canori, Michael; Krishnan, Gopinath; Vieira Souza Da Silva, Yasmim; Eriani, Gilbert; Albers, Mark W.; Arnold, Steven E.; Song, Yuyu; Jain, Ankur; Chiu, Isaac M.; Zhang, Yong-Jie; Gao, Fen-Biao; Wainger, Brian J.; Polymenidou, Magdalini; Petrucelli, Leonard; Martin, Franck; Lagier-Tourenne, Clotilde
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Strasbourg; CNRS - National Institute for Biology (INSB); Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Mayo Clinic; University of Zurich; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Whitehead Institute; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Marine Biological Laboratory - Woods Hole
  摘要：GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation of either repeat RNAs and/or dipeptide repeat proteins (DPRs) translated from repeat-containing transcripts through repeat-associated non-AUG (RAN) translation. To disentangle RNA from DPR toxicity, we mutated a CUG codon predominantly used to initiate DPR translation from all three reading frame...
• Halt illegal cyber tiger trade in Asia AI翻译
  作者：Feng, Rui; Zhao, Chunzhi; Zhao, Yongjun
  作者单位：Hangzhou Normal University
• Lawmakers spend big on home state science projects AI翻译
  作者：Mervis, Jeffrey
• Ineffective marine protected areas in Azores AI翻译
  作者：Barreiros, Joao Pedro; Aguilar-Perera, Alfonso; Anderson, Antonio Batista; Barcelos, Luis M. D.; Beheregaray, Luciano B.; Diaz-Ferguson, Edgardo
  作者单位：Universidade dos Acores; Universidade dos Acores; Universidad Autonoma de Yucatan; Universidade Federal do Espirito Santo; Flinders University