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作者：Jones, Andrew T.; Marino, Alessandra E.; Martynyuk, Tetyana; Bournazos, Stylianos; Ravetch, Jeffrey V.
作者单位：Rockefeller University
摘要：Intravenous immunoglobulin (IVIG) administered at high doses is used to treat a wide array of autoimmune diseases. Studies in murine models have identified that the anti-inflammatory activity of IVIG is dependent on sialylation of the N-linked glycan on the CH2 domain of immunoglobulin G (IgG), the type I IgG inhibitory Fc receptor Fc gamma RIIB, and the type II Fc receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). We hypothesized that DC-SIGN, ...
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作者：Krammer, Sorin M. S.
作者单位：University of Southampton
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作者：Maavara, Taylor; Yuan, Zimin; Johnson, Andrew M.; Zhang, Shuang; Aho, Kelly S.; Brinkerhoff, Craig B.; Logozzo, Laura A.; Raymond, Peter
作者单位：Cary Institute of Ecosystem Studies; University of Leeds; Peking University; Texas A&M University System; Texas A&M University College Station; Boston University; Yale University; Yale University
摘要：River metabolism is among the most uncertain fluxes in the global carbon cycle. We present estimates for gross primary productivity (GPP) and ecosystem respiration (ER) for more than 175,000 rivers across the contiguous United States (CONUS), including metabolic responses to extreme hydrological conditions. Our model predicts an annual GPP in CONUS rivers of 10.1 teragrams of carbon per year and an ER of 18.7 teragrams of carbon per year, which implies that net ecosystem productivity (NEP; whe...
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作者：Wu, Jin; Yang, Hongyuan
作者单位：University of Texas System; University of Texas Health Science Center Houston
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作者：Pasca, Sergiu P.; Arlotta, Paola; Campbell, Philip; Charo, Alta; Evans, John H.; Farahany, Nita; Gage, Fred H.; Godfrey-Smith, Peter; Hyun, Insoo; Kriegstein, Arnold R.; Melloni, Lucia; Ming, Guo-Li; Moreno, Jonathan D.; Sugarman, Jeremy; Temple, Sally; Testa, Giuseppe; Greely, Henry T.
作者单位：Stanford Medicine; Stanford University; Stanford University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California San Diego; Duke University; Salk Institute; University of Sydney; Harvard University; Harvard Medical School; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Johns Hopkins University; Johns Hopkins Medicine; University of Milan; Human Technopole; Stanford University
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作者：Zhang, He; Liu, Hailong; Xu, Yushan; Huang, Haoran; Liu, Yiming; Wang, Jia; Qin, Yan; Wang, Haiyan; Ma, Lili; Xun, Zhiyuan; Hou, Xuzhuang; Lu, Timothy K.; Cao, Jicong
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Despite the success of messenger RNA (mRNA) COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that uses transformer architectures tailored for mRNA coding sequences (CDSs) and untranslated regions (UTRs) to design mRNAs with enhanced expression and stability. GEMORNA-designed full-length mRNAs exhibited up to a 41-fold increase in firefly luciferase expression compared with an optimized benchmark in vit...
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作者：Latif, Sarmad Dashti
