6796期

最新文章

• New demand goals for energy and climate resilience Current climate goals, largely focused on energy supply, should be complemented by targeting demand AI翻译
  作者：Bento, N.; Grubler, A.; Nakicenovic, N.
  作者单位：Instituto Universitario de Lisboa; International Institute for Applied Systems Analysis (IIASA); University of Leoben
• Early dynamics of the genome in Down syndrome AI翻译
  作者：Haydar, Tarik; Li, Zhen
  作者单位：Boston University
• Clouds moderate Amazon deforestation's climate effect AI翻译
  作者：Myhre, Gunnar
• A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex AI翻译
  作者：Vuong, Celine K.; Weber, Alexis; Seong, Patrick; Matoba, Nana; Chen, Yu-Jen; Peyer, Jordan; Younesi, Shahab; Salinda, Angelo; Gomez, Daniel; Rivas, Gabriella; Morales, Abril; Shafie, Beck; Zhang, Pan; Nichterwitz, Susanne; Qi, Le; Fernandez, Nolan T.; Friedman, Emily; Love, Michael I.; Gandal, Michael J.; Geschwind, Daniel H.; Lowry, William E.; Stein, Jason L.; de la Torre-Ubieta, Luis
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Fudan University
  摘要：Down syndrome (DS) is the most common genetic cause of intellectual disability, yet the cellular and molecular mechanisms driving this developmental disorder remain unclear. In this study, we profiled human mid-gestation neocortex with snMultiomics across 26 donors. We observed a reduction in neural progenitors and corticothalamic neurons and an increase of intratelencephalic neurons, accompanied by accelerated neuronal specification. We uncovered widespread changes in gene expression, chromat...
• Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq AI翻译
  作者：Zhang, Liansheng; Ma, Qi; Kong, Xiangrui; Zou, Weijuan; Wang, Bo; Wu, Bin; Cai, Shicheng; Bai, Tao; Tan, Runlin; Dai, Ziji; Liu, Xingyu; Jia, Zhiheng; Zhang, Meimei; Li, Tianwen; Zheng, Yuanyi; Hu, Xinde; Wu, Jianrong; Xu, Zhengzheng; Zhou, Haibo
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; Fudan University; Fudan University; Shanghai Center for Brain Science & Brain-Inspired Technology
  摘要：An in vivo approach combining high-throughput screening with cell type-specific readouts could enable elucidation of genotype-phenotype relationships in complex tissues. We developed an in vivo gain-of-function Perturb-seq platform, termed iGOF-Perturb-seq, to build a functional atlas of similar to 1000 transcription factors (TFs) in astrocytes, a cell type essential to many brain functions. We then identified cofunctional modules, annotated uncharacterized TFs, and predicted disease-associate...
• The Dark Frontier: Unlocking the Secrets of the Deep Sea AI翻译
  作者：Trethewey, Laura
• Earliest octopuses were giant top predators in Cretaceous oceans AI翻译
  作者：Ikegami, Shin; Mutterlose, Jorg; Sugiura, Kanta; Takeda, Yusuke; Derin, Mehmet Oguz; Kubota, Aya; Tainaka, Kazuki; Harada, Takahiro; Nishida, Harufumi; Iba, Yasuhiro
  作者单位：Hokkaido University; Ruhr University Bochum; Japan Synchrotron Radiation Research Institute; Osaka Metropolitan University; Niigata University; Chuo University
  摘要：Top predators drive changes in ecosystem structure. For the last similar to 370 million years, large-sized vertebrates have dominated the apex of the marine food chain, while invertebrates have served as smaller prey. Here we describe invertebrate top predators from this age of vertebrates, the earliest finned octopuses (Cirrata) from Late Cretaceous sediments (similar to 100 to 72 million years ago), as identified based on huge, exceptionally well-preserved fossil jaws and their wear. This ex...
• Mechanical load inhibits cancer growth in mouse and human hearts AI翻译
  作者：Ciucci, Giulio; Lorizio, Daniela; Bartoloni, Nicoletta; Budini, Mauricio; Colliva, Andrea; Vodret, Simone; Nguyen, Anh-Vu; Ciacci, Lorenzo; Texler, Bernhard; Cardini, Benno; Oberhuber, Rupert; Bindelli, Sofia; Del Giudice, Ilaria Luciana Carlotta; Vuerich, Roman; Riccitelli, Francesco; Zago, Elena; Finsberg, Henrik Nicolay; Chiesa, Mattia; Perrucci, Gianluca Lorenzo; Bussani, Rossana; Silvestri, Furio; Maglione, Manuel; Dellino, Gaetano Ivan; Sinagra, Gianfranco; Giacca, Mauro; Eschenhagen, Thomas; Golino, Paolo; Pompilio, Giulio; Pelicci, Pier Giuseppe; Andolfi, Laura; Pinamonti, Maurizio; Dal Ferro, Matteo; Wall, Samuel; Loffredo, Francesco S.; Zacchigna, Serena
  作者单位：International Center for Genetic Engineering & Biotechnology (ICGEB); IRCCS Centro Cardiologico Monzino; University of Trieste; Medical University of Innsbruck; IRCCS European Institute of Oncology (IEO); University of Milan; University of London; King's College London; University of London; King's College London; University of Hamburg; University Medical Center Hamburg-Eppendorf; German Centre for Cardiovascular Research; Universita della Campania Vanvitelli; University of Milan; Consiglio Nazionale delle Ricerche (CNR); Istituto Officina dei Materiali (IOM-CNR)
  摘要：The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration may also protect against cancer. In this work, we investigated the role of mechanical load and used in vivo cancer models and ex vivo engineered heart tissues to show that mechanical load reduces cancer cell proliferation in the myocardium. Spatial transcriptomics of human cardiac metastases reveal...
• Molecular solar thermal energy storage in Dewar pyrimidone beyond 1.6 megajoules per kilogram AI翻译
  作者：Nguyen, Han P. Q.; Maertens, Alexander J.; Baker, Benjamin A.; Wu, Nathan M. -W.; Ye, Zihao; Zhou, Qingyang; Qiu, Qianfeng; Kaur, Navneet; Berkinsky, David B.; Shulenberger, Katherine E.; Houk, K. N.; Han, Grace G. D.
  作者单位：University of California System; University of California Santa Barbara; Brandeis University; University of California System; University of California Los Angeles
  摘要：Storing sunlight in a compact and rechargeable form remains a central challenge for solar energy utilization. Molecular solar thermal (MOST) energy storage systems, which harness photon energy and release it as heat on demand, provide a direct approach but have long failed to meet practical benchmarks. Inspired by the architecture of DNA, we report a pyrimidone-based MOST system that stores energy in the strained Dewar photoisomer upon excitation at 300 nanometers. Designed with sustainability...
• Writing the rainbow Color resists simple description-that has not stopped dictionary lexicographers from trying AI翻译
  作者：Kupferschmidt, Kai