6778期

最新文章

• Replenishing sapped groundwater could trigger small earthquakes AI翻译
  作者：Richter, Hannah
• Infrared as a pollination signal: Relying on infrared communication over visual color could have limited cycad evolution AI翻译
  作者：Glover, Beverley J.; Webb, Alex A. R.
  作者单位：University of Cambridge
• Invisible heat insulators AI翻译
  作者：Li, Longnan; Li, Wei
  作者单位：Chinese Academy of Sciences; Changchun Institute of Optics, Fine Mechanics & Physics, CAS
• Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode (vol 331, pg 473, 2011) AI翻译
  作者：Santos, J. M.
• Planet protector AI翻译
  作者：Andrews, Robin George
• Mapping the online manipulation economy AI翻译
  作者：Dek, A.; Kyrychenko, Y.; van der Linden, S.; Roozenbeek, J.
  作者单位：University of Cambridge; University of Cambridge
  摘要：The internet is awash with inauthentic activity. Although some of this activity is harmless, a substantial proportion can be classified as malicious, including bots designed to steal personal data, networks of inauthentic social media accounts promoting crypto scams, and coordinated political influence operations (1, 2). To enhance security, online platforms have implemented measures to counter inauthentic activity, with most requiring users to confirm account authenticity via a one-time passw...
• Substantial water retained early in Earth's deep mantle AI翻译
  作者：Lu, Wenhua; Yang, Ya-Nan; Long, Tao; Xian, Haiyang; Li, Yuan; Du, Zhixue
  作者单位：Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; China Geological Survey; Chinese Academy of Geological Sciences; Institute of Geology, Chinese Academy of Geological Sciences; University of Gothenburg; University of Bayreuth
  摘要：Earth's water was likely acquired early, when our planet was extensively molten because of large to giant impacts. How such early water was retained and distributed within a crystallizing mantle remains unclear. In this study, we investigated partitioning of water between bridgmanite, the first and primary mantle mineral to crystallize, and coexisting melt through systematic high-pressure experiments. Our results demonstrate that partitioning of water into bridgmanite is strongly enhanced by i...
• Multispecies pangenomes reveal a pervasive influence of population size on structural variation AI翻译
  作者：Edwards, Scott V.; Fang, Bohao; Khost, Danielle; Kolyfetis, George E.; Cheek, Rebecca G.; Deraad, Devon A.; Chen, Nancy; Fitzpatrick, John W.; Mccormack, John E.; Funk, W. Chris; Ghalambor, Cameron K.; Garrison, Erik; Guarracino, Andrea; Li, Heng; Sackton, Timothy B.
  作者单位：Harvard University; Harvard University; Harvard University; Colorado State University System; Colorado State University Fort Collins; University of California System; University of California Los Angeles; University of Rochester; Cornell University; Occidental College; Norwegian University of Science & Technology (NTNU); University of Tennessee System; University of Tennessee Health Science Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Structural variants (SVs) are widespread in vertebrate genomes, yet their evolutionary dynamics remain poorly understood. Using 45 long-read de novo genome assemblies and pangenome tools, we analyze SVs among three closely related species of North American jays (Aphelocoma, scrub-jays) displaying a 55-fold range in effective population size. We find rapid evolution of genome architecture, including similar to 100-megabase decreases in genome size driven by shifts in complex satellite landscape...
• Chromosome shattering in cancer AI翻译
  作者：Clarke, Stanley; Imielinski, Marcin
  作者单位：New York University; NYU Langone Medical Center
• Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes AI翻译
  作者：Krupina, Ksenia; Goginashvili, Alexander; Baughn, Michael W.; Moore, Stephen; Steele, Christopher D.; Nguyen, Amy T.; Zhang, Daniel L.; Koeppel, Jonas; Trivedi, Prasad; Malhotra, Aarti; Jenkins, David; Shiau, Andrew K.; Miyake, Yohei; Koga, Tomoyuki; Miki, Shunichiro; Furnari, Frank B.; Campbell, Peter J.; Alexandrov, Ludmil B.; Cleveland, Don W.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of Cambridge; Wellcome Trust Sanger Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of Minnesota System; University of Minnesota Twin Cities; University of Tsukuba
  摘要：Genome instability, including chromothripsis, is a hallmark of cancer. Cancer cells frequently contain micronuclei-small, nucleus-like structures formed by chromosome missegregation-that are susceptible to rupture, exposing chromatin to cytoplasmic nucleases. Through an unbiased, imaging-based small interfering RNA screen that targeted all 204 known and putative human nucleases, we identified a previously uncharacterized cytoplasmic endonuclease, NEDD4-binding protein 2 (N4BP2), that enters ru...