6778期

最新文章

• Advances in reproductive technology mean rethinking the meaning of autonomy AI翻译
  作者：Scully, Jackie Leach
• Deep mantle clues to Earth's watery beginning AI翻译
  作者：Walter, Michael
  作者单位：Carnegie Institution for Science
• Cryo-electron microscopy reveals hydrogen positions and water networks in photosystem II (vol 384, pg 1349, 2024) AI翻译
  作者：Hussein, R.
• Cancer-fighting cells made in body help patients AI翻译
  作者：Leslie, Mitch
• Three-component assembly and structure-function relationships of (-)-gukulenin A AI翻译
  作者：Gupta, Vaani; Wang, Zechun; Combs, Joshua B.; Wright, Timothy; Chen, Lei; Lin, Boxu; Holmes, Ryan; Qin, Bo; Oh, Joonseok; Crawford, Jason M.; Herzon, Seth B.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Peking University; New York University
  摘要：alpha-Tropolones comprise an unsaturated seven-membered ring bearing a hydroxyl substituent adjacent to a polarized carbon-oxygen pi bond. This polarization imparts a permanent molecular dipole and aromatic stabilization to the ring, resulting in distinct physical properties, including affinity for divalent metals and ambiphilic reactivity. Among secondary metabolites that contain alpha-tropolones, the pseudodimeric isolate (-)-gukulenin A (7) stands out for its complexity and has shown promis...
• Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells AI翻译
  作者：Kiuchi, Masahiro; Nemoto, Masahiro; Yagyu, Hiroyuki; Aoki, Ami; Iwamura, Chiaki; Sugimoto, Hikaru; Masuo, Yuki; Morita, Hajime; Ma, Shuhe; Okuno, Yukiko; Hishiya, Takahisa; Tsuji, Kaori; Sasaki, Atsushi; Kokubo, Kota; Ohishi, Kanae; Shinmi, Rie; Sonobe, Yuri; Iinuma, Tomohisa; Yonekura, Syuji; Yokomizo, Tomomasa; Komatsu, Norio; Onodera, Atsushi; Okumura, Shinya; Ito, Takashi; Hatano, Etsuro; Tsuruyama, Tatsuaki; Kurashima, Yosuke; Mato, Naoko; Suzuki, Takuji; Kimura, Motoko Yagi; Motohashi, Shinichiro; Kawakami, Eiryo; Ueno, Hideki; Tumes, Damon J.; Hanazawa, Toyoyuki; Nakayama, Toshinori; Hirahara, Kiyoshi
  作者单位：Chiba University; Yokohama City University; Niigata University; Chiba University; RIKEN; Kyoto University; Kyoto University; Kyoto University; Kyoto University; Chiba University; Chiba University; Tokyo Women's Medical University; Juntendo University; Chiba University; Chiba University; Kyoto University; Kyoto University; Chiba University; Jichi Medical University; Chiba University; Chiba University; Chiba University; Centre for Cancer Biology; Adelaide University; University of South Australia; SA Pathology; Adelaide University; University of Adelaide; Japan Science & Technology Agency (JST)
  摘要：CD4+ tissue-resident memory T (TRM) cells contribute to host defense and to the pathogenesis of chronic inflammatory diseases, but the molecules that direct their differentiation are unknown. We found that the transcription factor hepatic leukemia factor (HLF) could direct the tissue residency program and function of CD4+ TRM cells. HLF simultaneously up-regulated tissue retention receptors, down-regulated tissue egress receptors, and promoted proinflammatory CD4+ TRM cells by inducing Bhlhe40...
• The experiment I didn't plan AI翻译
  作者：Gulia-Nuss, Monika
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno
• NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT AI翻译
  作者：Wu, Zheng; Nguyen, Phong T.; Sondhi, Varun; Yao, Run-Wen; Lu, Zhifang; Dai, Tao; Chiang, Jui-Chung; Cai, Feng; Williams, Imani M.; Blatt, Eliot B.; Shang, Zengfu; Cai, Ling; Zhang, Jing; Moore, Mya D.; Alshamleh, Islam; Li, Xiangyi; Ogu, Tamaratare; Zacharias, Lauren G.; Winston, Rainah; Patricio, Joao S.; Johnson, Xandria; Chen, Wei-Min; Cong, Qian; Mathews, Thomas P.; Zhang, Yuanyuan; Zhang, Limei; Deberardinis, Ralph J.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; Howard Hughes Medical Institute; University of Texas Southwestern Medical Center; University of Nebraska System; University of Nebraska Lincoln; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that are incompletely understood. We identified Nudix hydrolase 5 (NUDT5) as a DNPB regulator. During purine salvage, NUDT5 suppresses DNPB independently of its catalytic function but rather through interaction with phosphoribosyl pyrophosphate amidotransferase (PPAT), the rate-limiting enzyme in the D...
• Arctic route demands advanced marine coatings AI翻译
  作者：Zhang, Tao; Wang, Liping
  作者单位：Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS
• Mesoporous optically clear heat insulators for sustainable building envelopes AI翻译
  作者：Bhardwaj, Amit; Fleury, Blaise; Senyuk, Bohdan; Abraham, Eldho; ten Hove, Jan Bart; Lee, Taewoo; Cherpak, Vladyslav; Smalyukh, Ivan I.
  作者单位：University of Colorado System; University of Colorado Boulder; Hiroshima University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：Mesoporous materials exhibit highly controlled nanoscale structures, often templated by liquid crystalline assemblies of surfactants, with emergent and often designable physical properties. However, scaling their fabrication to be suitable for uses such as envelopes of buildings is challenging. In this work, we describe fabrication of flexible square-meter-sized films and multicentimeter-thick slabs made of three-dimensional spatial graphs of mesopore tubes that have all structural features un...