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作者:MEEKER, WQ
摘要:A test for independence between 2 dichotomous characteristics when data are obtained sequentially is suggested. Truncated sequential test regions are found, and the exact properties of the tests are evaluated. A numerical example is given, and test properties are compared with those of comparable fixed sample size tests.
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作者:LAGAKOS, SW; WILLIAMS, JS
作者单位:Harvard University; Colorado State University System; Colorado State University Fort Collins; State University of New York (SUNY) System; University at Buffalo, SUNY
摘要:A class of models was proposed for the analysis of censored survival data in situations where survival was affected by conditions which lead to censoring. The specific case where survival was exponential was examined in detail and the methods were applied to a lung cancer clinical trial [in humans].
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作者:BINDER, DA
摘要:A parametric model for partitioning individuals into mutually exclusive groups is given. A Bayesian analysis is applied and a loss structure imposed. A model-dependent definition of a similarity matrix is proposed, and estimates based on this matrix are justified in a decision-theoretic framework. Some existing cluster analysis techniques are derived as special limiting cases. The results of the procedure applied to 2 data sets are compared with other analyses.
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作者:HOLT, JD
摘要:Several models for dependent competing risk data are considered. The effects of certain risk factors or treatments are supposedly of primary interest; such effects are written as regression parameters in a proportional cause-specific hazards model. Techniques based on marginally sufficient statistics and partial likelihood are used for their estimation. Efficiency comparisons are made among estimates based on the suggested models. Special attention is given to the analysis of matched pair data...
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作者:WOOD, CL; ALTAVELA, MM
作者单位:Cornell University
摘要:The asymptotic distributions of the Kolmogorov-Smirnov goodness-of-fit statistics are considered when the hypothesized distribution is discrete. Each of the statistics apparently has the same distribution as a continuous functional of an associated empirical process on the unit interval. Using known weak convergence properties for the empirical process, the asymptotic distributions of the Kolmogorov-Smirnov statistics are derived. A discussion and example are included.
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作者:PRENTICE, RL; BRESLOW, NE
作者单位:Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle
摘要:The proportional hazards failure time model of Cox (1972) is adapted to the retrospective epidemiological study in which cases and controls are sampled from a population to relate disease incidence rates to exposure to suspected risk factors. The method permits simultaneous study of several exposure variables that may be discrete or continuous or a mixture of both, in the presence of additional explanatory variables and competing risks. The proportional hazards framework provides a fresh look ...
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作者:PRENTICE, RL
作者单位:University of Washington; University of Washington Seattle
摘要:Linear rank statistics are developed for tests on regression coefficients with censored data. These statistics arise as score statistics based on the marginal probability of a generalized rank vector. The observed Fisher information provides a variance estimator generally, while in certain special cases a permutation approach to variance estimation is also possible. The Wilcoxon test is generalized to regression tests with censored data. The log rank test is also produced as a special case.
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作者:CLAYTON, DG
作者单位:University of London; University College London; Royal Free London NHS Foundation Trust; UCL Medical School
摘要:The application of Cox''s (1972) regression model for censored survival data to epidemiological studies of chronic disease incidence is discussed. A related model for association in bivariate survivorship time distributions is proposed for the analysis of familial tendency in [human] disease incidence. The possible extension of the model to general multivariate survivorship distributions is indicated.
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作者:ROBINSON, JA
摘要:Let Y(x) be the toxicity associated with some [drug] dosage level x. Let the conditional distribution of Y be normal with mean linear in x. The optimal dosage is defined to be the largest value of x such that the probability that Y(x) does not exceed .eta. is at least .gamma., where .eta. is some threshold toxicity level and .gamma. is some specified tolerance probability. Recently, Eichhorn and Zacks have introduced the problem of sequentially and consistently estimating the optimal dosage at...
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作者:HAMILTON, DC; WATTS, DG
摘要:A simple approach to understanding the behavior of the partial autocorrelation function of seasonal time series is presented, based on a partial autocorrelation pattern. This pattern, which acts as a signature of the regular component of the model, is a simple composite of the autocorrelation and partial autocorrelation functions of the regular component.