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作者：Ma, Shujie; Song, Peter X. -K.
作者单位：University of California System; University of California Riverside; University of Michigan System; University of Michigan
摘要：It has been a long history of using interactions in regression analysis to investigate alterations in covariate-effects on response variables. In this article, we aim to address two kinds of new challenges arising from the inclusion of such high-order effects in the regression model for complex data. The first kind concerns a situation where interaction effects of individual covariates are weak but those of combined covariates are strong, and the other kind pertains to the presence of nonlinea...
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作者：Wikle, Christopher K.; Holan, Scott H.
作者单位：University of Missouri System; University of Missouri Columbia
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作者：Heaton, Matthew J.; Sain, Stephan R.; Monaghan, Andrew J.; Wilhelmi, Olga V.; Hayden, Mary H.
作者单位：Brigham Young University; National Center Atmospheric Research (NCAR) - USA
摘要：We analyze an incomplete marked point pattern of heat-related 911 calls between the years 2006-2010 in Houston, TX, to primarily investigate conditions that are associated with increased vulnerability to heat-related morbidity and, secondarily, build a statistical model that can be used as a public health tool to predict the volume of 911 calls given a time frame and heat exposure. We model the calls as arising from a nonhomogenous Cox process with unknown intensity measure. By using the kerne...
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作者：Zhu, Jian; Raghunathan, Trivellore E.
作者单位：University of Michigan System; University of Michigan
摘要：A sequential regression or chained equations imputation approach uses a Gibbs sampling-type iterative algorithm that imputes the missing values using a sequence of conditional regression models. It is a flexible approach for handling different types of variables and complex data structures. Many simulation studies have shown that the multiple imputation inferences based on this procedure have desirable repeated sampling properties. However, a theoretical weakness of this approach is that the s...
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作者：Ma, We; Hu, Feifang; Zhang, Lixin
作者单位：University of Virginia; George Washington University; Zhejiang University
摘要：Covariate-adaptive designs are often implemented to balance important covariates in clinical trials. However, the theoretical properties of conventional testing hypotheses are usually unknown under covariate-adaptive randomized clinical trials. In the literature, most studies are based on simulations. In this article, we provide theoretical foundation of hypothesis testing under covariate-adaptive designs based on linear models. We derive the asymptotic distributions of the test statistics of ...
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作者：Ke, Zheng Tracy; Fan, Jianqing; Wu, Yichao
作者单位：Princeton University; North Carolina State University
摘要：This article explores the homogeneity of coefficients in high-dimensional regression, which extends the sparsity concept and is more general and suitable for many applications. Homogeneity arises when regression coefficients corresponding to neighboring geographical regions or a similar cluster of covariates are expected to be approximately the same. Sparsity corresponds to a special case of homogeneity with a large cluster of known atom zero. In this article, we propose a new method called cl...
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作者：Leeb, Hannes
作者单位：University of Vienna
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作者：Sun, Wei; Liu, Yufeng; Crowley, James J.; Chen, Ting-Huei; Zhou, Hua; Chu, Haitao; Huang, Shunping; Kuan, Pei-Fen; Li, Yuan; Miller, Darla; Shaw, Ginger; Wu, Yichao; Zhabotynsky, Vasyl; McMillan, Leonard; Zou, Fei; Sullivan, Patrick F.; de Villena, Fernando Pardo-Manuel
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; North Carolina State University; University of Minnesota System; University of Minnesota Twin Cities; University of North Carolina; University of North Carolina Chapel Hill
摘要：We have developed a statistical method named IsoDOT to assess differential isoform expression (DIE) and differential isoform usage (DIU) using RNA-seq data. Here isoform usage refers to relative isoform expression given the total expression of the corresponding gene. IsoDOT performs two tasks that cannot be accomplished by existing methods: to test DIE/DIU with respect to a continuous covariate, and to test DIE/DIU for one case versus one control. The latter task is not an uncommon situation i...
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作者：Hahn, P. Richard; Carvalho, Carlos M.
作者单位：University of Chicago; University of Texas System; University of Texas Austin
摘要：Selecting a subset of variables for linear models remains an active area of research. This article reviews many of the recent contributions to the Bayesian model selection and shrinkage prior literature. A posterior variable selection summary is proposed, which distills a full posterior distribution over regression coefficients into a sequence of sparse linear predictors.
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作者：Tang, Xu; Gan, Fah F.; Zhang, Lingyun
作者单位：National University of Singapore; Beijing Normal-Hong Kong Baptist University
摘要：The cumulative sum charting procedure is traditionally used in the manufacturing industry for monitoring the quality of products. Recently, it has been extended to monitoring surgical outcomes. Unlike a manufacturing process where the raw material is usually reasonably homogeneous, patients' risks of surgical failure are usually different. It has been proposed in the literature that the binary outcomes from a surgical procedure be adjusted using the preoperative risk based on a likelihood-rati...
