4期

最新文章

• A FAST ALGORITHM FOR DETECTING GENE-GENE INTERACTIONS IN GENOME-WIDE ASSOCIATION STUDIES AI翻译
  作者：Li, Jiahan; Zhong, Wei; Li, Runze; Wu, Rongling
  作者单位：University of Notre Dame; Xiamen University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health
  摘要：With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches. Although many such approaches have been developed and used to identify single-nucleotide polymorphisms (SNPs) that are associated with complex traits or diseases, few are able to detect gene-gene interactions among different SNPs. Genetic interactions, also kn...
• IMPUTATION OF TRUNCATED p-VALUES FOR META-ANALYSIS METHODS AND ITS GENOMIC APPLICATION AI翻译
  作者：Tang, Shaowu; Ding, Ying; Sibille, Etienne; Mogil, Jeffrey S.; Lariviere, William R.; Tseng, George C.
  作者单位：Roche Holding; Roche Holding USA; Pfizer; Pfizer USA; University of Toronto; Centre for Addiction & Mental Health - Canada; McGill University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Microarray analysis to monitor expression activities in thousands of genes simultaneously has become routine in biomedical research during the past decade. A tremendous amount of expression profiles are generated and stored in the public domain and information integration by meta-analysis to detect differentially expressed (DE) genes has become popular to obtain increased statistical power and validated findings. Methods that aggregate transformed p-value evidence have been widely used in geno...
• DETECTING DUPLICATES IN A HOMICIDE REGISTRY USING A BAYESIAN PARTITIONING APPROACH AI翻译
  作者：Sadinle, Mauricio
  作者单位：Carnegie Mellon University
  摘要：Finding duplicates in homicide registries is an important step in keeping an accurate account of lethal violence. This task is not trivial when unique identifiers of the individuals are not available, and it is especially challenging when records are subject to errors and missing values. Traditional approaches to duplicate detection output independent decisions on the coreference status of each pair of records, which often leads to nontransitive decisions that have to be reconciled in some ad-...
• NONPARAMETRIC INFERENCE IN A STEREOLOGICAL MODEL WITH ORIENTED CYLINDERS APPLIED TO DUAL PHASE STEEL AI翻译
  作者：McGarrity, K. S.; Sietsma, J.; Jongbloed, G.
  作者单位：Delft University of Technology; Delft University of Technology
  摘要：Oriented circular cylinders in an opaque medium are used to represent certain microstructural objects in steel. The opaque medium is sliced parallel to the cylinder axes of symmetry and the cut-plane contains the observable rectangular profiles of the cylinders. A one-to-one relation between the joint density of the squared radius and height of the 3D cylinders and the joint density of the squared half-width and height of the observable 2D rectangles is established. We propose a nonparametric ...
• EQUIVALENCE TESTING FOR FUNCTIONAL DATA WITH AN APPLICATION TO COMPARING PULMONARY FUNCTION DEVICES AI翻译
  作者：Fogarty, Colin B.; Small, Dylan S.
  作者单位：University of Pennsylvania
  摘要：Equivalence testing for scalar data has been well addressed in the literature, however, the same cannot be said for functional data. The resultant complexity from maintaining the functional structure of the data, rather than using a scalar transformation to reduce dimensionality, renders the existing literature on equivalence testing inadequate for the desired inference. We propose a framework for equivalence testing for functional data within both the frequentist and Bayesian paradigms. This ...
• REJOINDER: SPATIAL ACCESSIBILITY OF PEDIATRIC PRIMARY HEALTHCARE: MEASUREMENT AND INFERENCE AI翻译
  作者：Nobles, Mallory; Serban, Nicoleta; Swann, Julie
  作者单位：University System of Georgia; Georgia Institute of Technology
• A PERMUTATIONAL-SPLITTING SAMPLE PROCEDURE TO QUANTIFY EXPERT OPINION ON CLUSTERS OF CHEMICAL COMPOUNDS USING HIGH-DIMENSIONAL DATA AI翻译
  作者：Milanzi, Elasma; Alonso, Ariel; Buyck, Christophe; Molenberghs, Geert; Bijnens, Luc
  作者单位：Hasselt University; Maastricht University; Johnson & Johnson; Janssen Pharmaceuticals; Johson & Johnson Belgium; KU Leuven
  摘要：Expert opinion plays an important role when selecting promising clusters of chemical compounds in the drug discovery process. We propose a method to quantify these qualitative assessments using hierarchical models. However, with the most commonly available computing resources, the high dimensionality of the vectors of fixed effects and correlated responses renders maximum likelihood unfeasible in this scenario. We devise a reliable procedure to tackle this problem and show, using theoretical a...
• RECONSTRUCTING PAST TEMPERATURES FROM NATURAL PROXIES AND ESTIMATED CLIMATE FORCINGS USING SHORT- AND LONG-MEMORY MODELS AI翻译
  作者：Barboza, Luis; Li, Bo; Tingley, Martin P.; Viens, Frederi G.
  作者单位：Universidad Costa Rica; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Harvard University; University of Illinois System; University of Illinois Urbana-Champaign; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：We produce new reconstructions of Northern Hemisphere annually averaged temperature anomalies back to 1000 AD, and explore the effects of including external climate forcings within the reconstruction and of accounting for short-memory and long-memory features. Our reconstructions are based on two linear models, with the first linking the latent temperature series to three main external forcings (solar irradiance, greenhouse gas concentration and volcanism), and the second linking the observed ...
• FUNCTIONAL RESPONSE ADDITIVE MODEL ESTIMATION WITH ONLINE VIRTUAL STOCK MARKETS AI翻译
  作者：Fan, Yingying; Foutz, Natasha; James, Gareth M.; Jank, Wolfgang
  作者单位：University of Southern California; University of Virginia; State University System of Florida; University of South Florida
  摘要：While functional regression models have received increasing attention recently, most existing approaches assume both a linear relationship and a scalar response variable. We suggest a new method, Functional Response Additive Model Estimation (FRAME), which extends the usual linear regression model to situations involving both functional predictors, Xj (t), scalar predictors, Z(k), and functional responses, Y(s). Our approach uses a penalized least squares optimization criterion to automaticall...
• REDUCED-RANK SPATIO-TEMPORAL MODELING OF AIR POLLUTION CONCENTRATIONS IN THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS AND AIR POLLUTION AI翻译
  作者：Olives, Casey; Sheppard, Lianne; Lindstrom, Johan; Sampson, Paul D.; Kaufman, Joel D.; Szpiro, Adam A.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Lund University; University of Washington; University of Washington Seattle
  摘要：There is growing evidence in the epidemiologic literature of the relationship between air pollution and adverse health outcomes. Prediction of individual air pollution exposure in the Environmental Protection Agency (EPA) funded Multi-Ethnic Study of Atheroscelerosis and Air Pollution (MESA Air) study relies on a flexible spatio-temporal prediction model that integrates land-use regression with kriging to account for spatial dependence in pollutant concentrations. Temporal variability is captu...