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作者：Enki, Doyo G.; Noufaily, Angela; Farrington, C. Paddy
作者单位：Open University - UK
摘要：We propose a new parametric time-varying shared frailty model to represent changes over time in population heterogeneity, for use with bivariate current status data. The model uses a power transformation of a time-invariant frailty U, and is particularly convenient when U is a member of the generalized gamma family. This model avoids some shortcomings of a previously suggested time-varying frailty model, notably time-dependent support. We describe some key properties of the model, including it...
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作者：Mcparland, Damien; Gormley, Isobel Claire; Mccormick, Tyler H.; Clark, Samuel J.; Kabudula, Chodziwadziwa Whiteson; Collinson, Mark A.
作者单位：University College Dublin; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Witwatersrand; University of Colorado System; University of Colorado Boulder; INDEPTH Network
摘要：The Agincourt Health and Demographic Surveillance System has since 2001 conducted a biannual household asset survey in order to quantify household socio-economic status (SES) in a rural population living in northeast South Africa. The survey contains binary, ordinal and nominal items. In the absence of income or expenditure data, the SES landscape in the study population is explored and described by clustering the households into homogeneous groups based on their asset status. A model-based ap...
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作者：Ditlevsen, Susanne; Samson, Adeline
作者单位：University of Copenhagen; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Mathematical Sciences (INSMI); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
摘要：Parameter estimation in multidimensional diffusion models with only one coordinate observed is highly relevant in many biological applications, but a statistically difficult problem. In neuroscience, the membrane potential evolution in single neurons can be measured at high frequency, but biophysical realistic models have to include the unobserved dynamics of ion channels. One such model is the stochastic Morris-Lecar model, defined by a nonlinear two-dimensional stochastic differential equati...
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作者：Li, Jiahan; Zhong, Wei; Li, Runze; Wu, Rongling
作者单位：University of Notre Dame; Xiamen University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health
摘要：With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches. Although many such approaches have been developed and used to identify single-nucleotide polymorphisms (SNPs) that are associated with complex traits or diseases, few are able to detect gene-gene interactions among different SNPs. Genetic interactions, also kn...
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作者：Tang, Shaowu; Ding, Ying; Sibille, Etienne; Mogil, Jeffrey S.; Lariviere, William R.; Tseng, George C.
作者单位：Roche Holding; Roche Holding USA; Pfizer; Pfizer USA; University of Toronto; Centre for Addiction & Mental Health - Canada; McGill University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Microarray analysis to monitor expression activities in thousands of genes simultaneously has become routine in biomedical research during the past decade. A tremendous amount of expression profiles are generated and stored in the public domain and information integration by meta-analysis to detect differentially expressed (DE) genes has become popular to obtain increased statistical power and validated findings. Methods that aggregate transformed p-value evidence have been widely used in geno...
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作者：Sadinle, Mauricio
作者单位：Carnegie Mellon University
摘要：Finding duplicates in homicide registries is an important step in keeping an accurate account of lethal violence. This task is not trivial when unique identifiers of the individuals are not available, and it is especially challenging when records are subject to errors and missing values. Traditional approaches to duplicate detection output independent decisions on the coreference status of each pair of records, which often leads to nontransitive decisions that have to be reconciled in some ad-...
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作者：McGarrity, K. S.; Sietsma, J.; Jongbloed, G.
作者单位：Delft University of Technology; Delft University of Technology
摘要：Oriented circular cylinders in an opaque medium are used to represent certain microstructural objects in steel. The opaque medium is sliced parallel to the cylinder axes of symmetry and the cut-plane contains the observable rectangular profiles of the cylinders. A one-to-one relation between the joint density of the squared radius and height of the 3D cylinders and the joint density of the squared half-width and height of the observable 2D rectangles is established. We propose a nonparametric ...
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作者：Fogarty, Colin B.; Small, Dylan S.
作者单位：University of Pennsylvania
摘要：Equivalence testing for scalar data has been well addressed in the literature, however, the same cannot be said for functional data. The resultant complexity from maintaining the functional structure of the data, rather than using a scalar transformation to reduce dimensionality, renders the existing literature on equivalence testing inadequate for the desired inference. We propose a framework for equivalence testing for functional data within both the frequentist and Bayesian paradigms. This ...
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作者：Nobles, Mallory; Serban, Nicoleta; Swann, Julie
作者单位：University System of Georgia; Georgia Institute of Technology
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作者：Afsari, Bahman; Braga-Neto, Ulisses M.; Geman, Donald
作者单位：Johns Hopkins University; Texas A&M University System; Texas A&M University College Station; Johns Hopkins University
摘要：Statistical methods for analyzing large-scale biomolecular data are commonplace in computational biology. A notable example is phenotype prediction from gene expression data, for instance, detecting human cancers, differentiating subtypes and predicting clinical outcomes. Still, clinical applications remain scarce. One reason is that the complexity of the decision rules that emerge from standard statistical learning impedes biological understanding, in particular, any mechanistic interpretatio...
