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作者：Carmichael, Iain; Calhoun, Benjamin C.; Hoadley, Katherine A.; Troester, Melissa A.; Geradts, Joseph; Couture, Heather D.; Olsson, Linnea; Perou, Charles M.; Niethammer, Marc; Hannig, Jan; Marron, J. S.
作者单位：University of Washington; University of Washington Seattle; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; East Carolina University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：The two main approaches in the study of breast cancer are histopathology (analyzing visual characteristics of tumors) and genomics. While both histopathology and genomics are fundamental to cancer research, the connections between these fields have been relatively superficial. We bridge this gap by investigating the Carolina Breast Cancer Study through the development of an integrative, exploratory analysis framework. Our analysis gives insights-some known, some novel-that are engaging to both...
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作者：D'Angelo, Silvia; Brennan, Lorraine; Gormley, Isobel Claire
作者单位：University College Dublin; University College Dublin
摘要：Metabolomic-based approaches have gained much attention in recent years, due to their promising potential to deliver objective tools for assessment of food intake. In particular, multiple biomarkers have emerged for single foods. However, there is a lack of statistical tools available for combining multiple biomarkers to quantitatively infer food intake. Furthermore, there is a paucity of approaches for estimating the uncertainty around biomarker-based inferred intake. Here, to estimate the re...
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作者：Gabitto, Mariano, I; Marie-Nelly, Herve; Pakman, Ari; Pataki, Andras; Darzacq, Xavier; Jordan, Michael, I
作者单位：Simons Foundation; Flatiron Institute; Stanford University; Li Ka Shing Center; University of California System; University of California Berkeley; Columbia University; Columbia University; University of California System; University of California Berkeley
摘要：We consider the problem of single-molecule identification in super-resolution microscopy. Super-resolution microscopy overcomes the diffraction limit by localizing individual fluorescing molecules in a field of view. This is particularly difficult since each individual molecule appears and disappears randomly across time and because the total number of molecules in the field of view is unknown. Additionally, data sets acquired with super-resolution microscopes can contain a large number of spu...
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作者：Ng, Tin Lok James; Murphy, Thomas Brendan; Westling, Ted; McCormick, Tyler H.; Fosdick, Bailey
作者单位：Trinity College Dublin; University College Dublin; University of Massachusetts System; University of Massachusetts Amherst; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Colorado State University System; Colorado State University Fort Collins
摘要：Dail Eireann is the principal chamber of the Irish parliament. The 31st Dail was in session from March 11th, 2011 to February 6th, 2016. Many of the members of the Dail were active on social media, and many were Twitter users who followed other members of the Dail. The pattern of Twitter following amongst these politicians provides insights into political alignment within the Dail. We propose a new model, called the generalized latent space stochastic blockmodel, which extends and generalizes ...
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作者：Watson, Joe; Joy, Ruth; Tollit, Dominic; Thornton, Sheila J.; Auger-Methe, Marie
作者单位：University of British Columbia; Simon Fraser University; Fisheries & Oceans Canada; University of British Columbia
摘要：Models of the spatial distribution of animals provide useful tools to help ecologists quantify species-environment relationships, and they are increasingly being used to help determine the impacts of climate and habitat changes on species. While high-quality survey-style data with known effort are sometimes available, often researchers have multiple datasets of varying quality and type. In particular, collections of sightings made by citizen scientists are becoming increasingly common, with no...
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作者：Bhuyan, Prajamitra; McCoy, Emma J.; Li, Haojie; Graham, Daniel J.
作者单位：Imperial College London; Southeast University - China; Imperial College London
摘要：Transport operators have a range of intervention options available to improve or enhance their networks. Such interventions are often made in the absence of sound evidence on resulting outcomes. Cycling superhighways were promoted as a sustainable and healthy travel mode, one of the aims of which was to reduce traffic congestion. Estimating the impacts that cycle superhighways have on congestion is complicated due to the nonrandom assignment of such intervention over the transport network. In ...
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作者：Viles, Weston D.; Madan, Juliette C.; Li, Hongzhe; Karagas, Margaret R.; Hoen, Anne G.
作者单位：Dartmouth College; University of Pennsylvania
摘要：The human gastrointestinal tract is an environment that hosts an ecosystem of microorganisms essential to human health. Vital biological processes emerge from fundamental inter- and intraspecies molecular interactions that influence the assembly and composition of the gut microbiota ecology. Here, we quantify the complexity of the ecological relationships within the human infant gut microbiota ecosystem as a function of the information contained in the nonlinear associations of a sequence of i...
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作者：Jadhav, Sneha; Ma, Chenjin; Jiang, Yefei; Shia, Ben-Chang; Ma, Shuangge
作者单位：Wake Forest University; Beijing University of Technology; Fu Jen Catholic University; Yale University
摘要：Prevalence is of essential importance in biomedical and public health research. In the classic paradigm it has been studied for each disease individually. Accumulating evidence has shown that diseases can be correlated. Joint analysis of prevalence can potentially provide important insights beyond individual-disease analysis but has not been well pursued. In this study we take advantage of the unique Taiwan National Health Insurance Research Database (NHIRD) and conduct the first pan-disease a...
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作者：Kim, Juhyun; Shen, Judong; Wang, Anran; Mehrotra, Devan, V; Ko, Seyoon; Zhou, Jin J.; Zhou, Hua
作者单位：University of California System; University of California Los Angeles; Merck & Company; Merck & Company USA; University of California System; University of California Los Angeles
摘要：Single nucleotide polymorphism (SNP) set analysis aggregates both common and rare variants and tests for association between phenotype(s) of interest and a set. However, multiple SNP-sets, such as genes, pathways, or sliding windows are usually investigated across the whole genome in which all groups are tested separately, followed by multiple testing adjustments. We propose a novel method to prioritize SNP-sets in a joint multivariate variance component model. Each SNP-set corresponds to a va...
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作者：Mohammed, Shariq; Bharath, Karthik; Kurtek, Sebastian; Rao, Arvind; Baladandayuthapani, Veerabhadran
作者单位：University of Michigan System; University of Michigan; University of Nottingham; University System of Ohio; Ohio State University
摘要：Recent technological advancements have enabled detailed investigation of associations between the molecular architecture and tumor heterogeneity through multisource integration of radiological imaging and genomic (radiogenomic) data. In this paper we integrate and harness radiogenomic data in patients with lower grade gliomas (LGG), a type of brain cancer, in order to develop a regression framework called RADIOHEAD (RADIOgenomic analysis incorporating tumor HEterogeneity in imAging through Den...
