Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions

• 成果类型: Article
• 署名作者: Ferenczi, Emily A.; Wang, Wengang; Biswas, Anushka; Pottala, Trent; Dong, Yihuan; Chan, Alison K.; Albanese, Madeline A.; Sohur, Raina S.; Jia, Tingying; Mastro, Kevin J.; Sabatini, Bernardo L.
• 署名单位: Harvard University; Howard Hughes Medical Institute; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Princeton University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2423367122
• 发表日期: 2025-06-10
• 页码: e2423367122
• 关键词: globus pallidus externa; pallidocortical; corticopallidal; reciprocal; nonmotor; DEEP-BRAIN-STIMULATION; basal ganglia; functional-organization; subthalamic nucleus; neurons; rat; cells; circuits; PATHWAY; output

摘要

The globus pallidus externa (GPe) is a heterogeneous nucleus of the basal ganglia, with intricate connections to other basal ganglia nuclei, as well as direct connections to the cortex. The anatomic, molecular, and electrophysiologic properties of cortex-projecting pallidocortical neurons are not well characterized. Here, we show that pallidocortical neurons project to diverse motor and nonmotor cortical regions, are organized topographically in the GPe, and segregate into at least two distinct electrophysiological and molecular phenotypes. In addition, we find that the GPe receives direct synaptic input from deep layers of diverse motor and nonmotor cortical regions, some of which form reciprocal connections onto pallidocortical neurons. These results demonstrate the existence of a fast, bidirectional circuit between the GPe and the cortex that is ideally positioned to integrate information about behavioral goals, internal states, and environmental cues to rapidly modulate behavior.