Structural immunotherapy: Harnessing chemical design to build powerful next-generation therapeutics

• 成果类型: Article
• 署名作者: Teplensky, Michelle H.; Bourgeois, Julianna N.; Kudruk, Sergej; Petrosko, Sarah Hurst; Mirkin, Chad A.
• 署名单位: Boston University; Northwestern University; Northwestern University; Northwestern University; Chan Zuckerberg Initiative (CZI)
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2409553122
• 发表日期: 2025-11-03
• 页码: e2409553122
• 关键词: immunotherapy; NANOTECHNOLOGY; structural medicine; VACCINE NANODISCS; dendritic cells; cancer; delivery; activation; nanoparticles; cpg; Combinatorial; CHALLENGES; ADJUVANTS

摘要

Structural immunotherapy relies on the structural features of immunotherapeutics in addition to component identity to influence biodistribution, intra-or extracellular localization, target engagement, and processing kinetics. This strategy is poised to redefine how immunotherapeutics mobilize immunity against disease and transform our ability to harness structure-function relationships to enhance clinical outcomes.