Hierarchical sensory processing in zebrafish thalamocortical-like circuits

• 成果类型: Article
• 署名作者: Trinh, Anh-Tuan; Ostenrath, Anna Maria; del Castillo-Berges, Ignacio; Cachin, Fanchon; Koc, Mina; Kraus, Susanne; Serneels, Bram; Kawakami, Koichi; Yaksi, Emre
• 署名单位: Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); Koc University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Koc University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.aec2171
• 发表日期: 2026-08-27
• 页码: eaec2171
• 关键词: MULTISENSORY INTEGRATION; PREGLOMERULAR NUCLEUS; EVOLUTION; PALLIUM; pathways; telencephalon; ORGANIZATION; connections; INFORMATION; populations

摘要

Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in nonmammalian vertebrates remain underexplored. In this work, we investigated how the zebrafish pallium, a homolog of the vertebrate cortex, receives and processes sensory information and how its architecture compares to thalamocortical circuits in other vertebrates. We revealed that the preglomerular complex (PG), a thalamocortical-like pathway, is the primary source of visual and vibrational information to the zebrafish pallium. PG and its pallial projections exhibit sensory-specific and topographically organized responses. By contrast, pallial neurons display topographically organized hierarchies, ranging from sensory-specific to multimodal and coincidence-detecting nonlinear responses. Our results suggest that hierarchies of sensory transformations across topographically organized thalamocortical-like circuits reflect a convergent principle across vertebrates.