Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito

• 成果类型: Article
• 署名作者: Tennessen, Jacob A.; Brosula, Raphael; Chabanol, Estelle; Bickersmith, Sara; Early, Angela M.; Laws, Margaret; Kelley, Katrina A.; Grillet, Maria Eugenia; Gamboa, Dionicia; Lucas, Eric R.; Duchemin, Jean-Bernard; Quinones, Martha L.; Sallum, Maria Anice Mureb; Bergo, Eduardo S.; Moreno, Jorge E.; Nagi, Sanjay; Arisco, Nicholas J.; Sooklall, Mohini; Niles-Robin, Reza; Castro, Marcia C.; Cox, Horace; Gendrin, Mathilde; Conn, Jan E.; Neafsey, Daniel E.
• 署名单位: Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Universite Paris Cite; Institut Pasteur de Guyane; State University of New York (SUNY) System; Wadsworth Center; University of Central Venezuela; Universidad Peruana Cayetano Heredia; Liverpool School of Tropical Medicine; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; Universidad Nacional de Colombia; Universidade de Sao Paulo; Pasteur Network; Institut Pasteur Sao Paulo; State University of New York (SUNY) System; University at Albany, SUNY
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adw9761
• 发表日期: 2026-03-26
• 页码: 1373-1378
• 关键词: gene flow; resistance; selection; diptera; gambiae

摘要

Malaria in South America remains a serious public health problem. Anopheles (Nyssorhynchus) darlingi is the most important malaria vector across tropical Latin America. Vector-targeted disease control efforts require a thorough understanding of mosquito demographic and evolutionary patterns. We present and analyze whole genomes of 1094 An. darlingi (median depth 18x) from six South American countries. We observe deep geographic population structure, high genetic diversity including 13 putative segregating inversions, and no evidence for sympatric cryptic taxa despite high interpopulation divergence. Strong signals of selection are plausibly driven by insecticides, especially on cytochrome P450 genes. Our results will facilitate effective mosquito surveillance and control while highlighting ongoing challenges that a diverse vector poses for malaria elimination in the Western hemisphere.