Ontogeny of the spinal cord dorsal horn

• 成果类型: Article
• 署名作者: Roome, Robert Brian; Yadav, Archana; Flores, Lydia; Puarr, Amrit K.; Nardini, Diana; Richardson, Alexander; Waclaw, Ronald R.; Arkell, Ruth M.; Menon, Vilas; Johnson, Jane E.; Levine, Ariel J.
• 署名单位: National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; University of Texas System; University of Texas Southwestern Medical Center; Australian National University; John Curtin School of Medical Research; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University of Texas System; University of Texas Southwestern Medical Center
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adx5781
• 发表日期: 2026-01-08
• 页码: eadx5781
• 关键词: cell fate; ZIC GENES; mouse; rat; expression; neurons; pax3; differentiation; identification; specification

摘要

The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in behavior. An outstanding question is how this organization emerges during development from an apparently homogeneous pool of neural progenitors. Here, we show that mouse dorsal neurons are diversified by time, with families of related cell types born as temporal cohorts, and by a spatial-molecular gradient that specifies individual cell types. Excitatory neurons settle into a chronotopic arrangement that transforms their progressive birthdates into anatomical order and is required to establish proper laminae. We identified essential ontogenetic principles that shape dorsal progenitors into the diverse cell types and structure that subserve sensorimotor function.