Chinese Immune Multi-Omics Atlas

• 成果类型: Article
• 署名作者: Yin, Jianhua; Zheng, Yuhui; Huang, Zhuoli; Zhou, Wenwen; Yuan, Yue; Cai, Pengfei; Bai, Yong; Yang, Shichen; Gao, Yue; Duan, Shanshan; Wang, Yang; Xu, Zekai; Zhang, Wenxi; Zhang, Xinyu; Wei, Yilin; Huang, Yaling; Liu, Ying; Wang, Weikai; Yang, Tao; Zhang, Zhongjin; Chen, Xiaoya; Zhang, Xiru; Lv, Jingzhi; Li, Fupeng; Zhang, Yan; Zeng, Guodan; Wang, Xue; Ma, Wen; Hou, Guixue; Hao, Shijie; Liu, Chang; Lai, Yiwei; Liu, Panhong; Wang, Bo; Li, Yuxiang; Zhang, Wenwei; Gao, Peng; Xie, Jun; Esteban, Miguel A.; Gu, Ying; Liu, Xin; Ji, Jiansong; Qi, Ting; Liu, Boxiang; Wang, Hua; Zhao, Yi; Yang, Xiao; Wang, Xiangdong; Chen, Runsheng; Yang, Jian; Yin, Ye; Wang, Jian; Cao, Yanan; Xu, Xun; Liu, Longqi; Jin, Xin; Liu, Chuanyu
• 署名单位: Beijing Genomics Institute (BGI); Beijing Genomics Institute (BGI); Shanxi Medical University; Beijing Genomics Institute (BGI); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing Genomics Institute (BGI); South China University of Technology; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing Genomics Institute (BGI); Chinese University of Hong Kong; Northwest University Xi'an; Beijing Genomics Institute (BGI); Beijing Genomics Institute (BGI); Shanxi Medical University; Beijing Genomics Institute (BGI); Wenzhou Medical University; Westlake Laboratory; Westlake University; National University of Singapore; National University of Singapore; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); Anhui Medical University; Anhui Medical University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Computing Technology, CAS; Fujian Medical University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Fudan University; Chinese Academy of Sciences; Institute of Biophysics, CAS; Shanghai Jiao Tong University; South China University of Technology
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adt3130
• 发表日期: 2026-01-08
• 页码: eadt3130
• 关键词: genome-wide association; regulatory t-cells; gene-expression; disease risk; IL-12; DISCOVERY; FRAMEWORK; variants; patterns; drivers

摘要

Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetic variants through multi-omics analysis of more than 10 million circulating immune cells from 428 Chinese adults. CIMA established an enhancer-driven gene regulatory network comprising 237 robust regulons; identified 9600 eGenes and 52,361 caPeaks at cell type resolution; and revealed pleiotropic associations among immune-related disease risk loci, cis-expression quantitative trait loci (QTLs), and chromatin accessibility QTLs. Furthermore, the cell language model CIMA-CLM predicted chromatin accessibility and evaluated the effects of noncoding variants from chromatin sequences and gene expression. CIMA provides a comprehensive reference for immune-related disease research.