A tripartite genetic conflict system controls hybrid sterility in rice

• 成果类型: Article
• 署名作者: He, Xiaodong; Zhao, Zhigang; Shao, Kun; Yu, Xiaowen; Zhu, Ying; Tang, Jintao; Li, Jing; Zhang, Yunhui; Zhao, Keyu; Zheng, Xiaoming; Wang, Hongru; Li, Chao; Gan, Xiangchao; Dong, Xiaoou; Ren, Yulong; Xiong, Yehui; Wang, Jian; Hu, Yang; Cheng, Siqi; Yao, Bowen; Ye, Yulu; Guo, Song; Zhu, Yuantao; He, Ling; Shan, Tiaofeng; Xu, Chen; Xu, Jinxuan; Lu, Jiayu; Lei, Dekun; Jian, Anqi; Gao, Junwen; Cui, Song; Xu, Gencheng; Guo, Xiuping; Liu, Xi; Tian, Yunlu; Liu, Shijia; Jiang, Ling; Deng, Xianneng; Zhou, Jiawu; Tao, Dayun; Zeng, Yonglun; Chen, Letian; Wu, Chuanyin; Wang, Haiyang; Wang, Chaolong; Wan, Jianmin
• 署名单位: Nanjing Agricultural University; Chinese Academy of Agricultural Sciences; Institute of Crop Sciences, CAAS; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; South China Botanical Garden, CAS; South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Yunnan Academy of Agricultural Sciences; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.aec5252
• 发表日期: 2026-08-27
• 页码: 903-909
• 关键词: ORYZA-GLABERRIMA; sequence

摘要

Interspecific Asian-African hybrid rice could substantially boost yield but is limited by severe hybrid sterility. We identify RHS3 as a major quantitative trait locus controlling this trait. RHS3 encodes a tripartite toxin-antidote system composed of MAO, DUN, and JIA, in which MAO acts as a toxin that aborts gametes by disrupting mitochondrial function, whereas DUN and JIA function as antidotes that neutralize MAO toxicity, conferring a transmission advantage to the African allele. We demonstrate that detoxification relies on selective autophagy through formation of a tripartite JIA-DUN-MAO protein complex. We infer the de novo origin of RHS3 in the AA-genome rice lineage, illustrating a role for genetic conflict in speciation and suggesting strategies to harness heterosis between Asian and African rice.